... of a disease. A large proportion of disorders associated with mitochondria are induced by mutations or chemical inhibition of the mitochondrial complex I — the entry point to the electron transport chain. Subunits of the enzyme NADH: ubiquinone oxidoreductase, are encoded by both nuclear and mitochondrial DNA...

...Wojtek Steffen; Julia Steuber The respiratory complex I (electrogenic NADH:quinone oxidoreductase) has been considered to act exclusively as a H + pump. This was questioned when the search for the NADH-driven respiratory Na + pump in Klebsiella pneumoniae initiated by Peter Dimroth led...

...Leonid A. Sazanov; Rozbeh Baradaran; Rouslan G. Efremov; John M. Berrisford; Gurdeep Minhas Complex I (NADH:ubiquinone oxidoreductase) is central to cellular energy production, being the first and largest enzyme of the respiratory chain in mitochondria. It couples electron transfer from NADH...

...Judy Hirst; Martin S. King; Kenneth R. Pryde ROS (reactive oxygen species) are considered to be a major cause of cellular oxidative stress, linked to neuromuscular diseases and aging. Complex I (NADH:ubiquinone oxidoreductase) is one of the main contributors to superoxide production by mitochondria...

...T. Friedrich; S. Stolpe; D. Schneider; B. Barquera; P. Hellwig The energy-converting NADH:ubiquinone oxidoreductase, also known as respiratory complex I, couples the transfer of electrons from NADH to ubiquinone with the translocation of ions across the membrane. It was assumed that the complex...

...J. Hirst Complex I (NADH:ubiquinone oxidoreductase) is a membrane-bound, multisubunit enzyme. At present, there is no high-resolution structural model available for complex I and its mechanism of energy transduction is unknown. However, the subunit compositions of complex I from both eukaryotic...

...S. Miwa; M.D. Brand Mitochondria produce ROS (reactive oxygen species) as a by-product of aerobic respiration. Several studies in mammals and birds suggest that the most physiologically relevant ROS production is from complex I following reverse electron flow, and is highly sensitive to membrane...