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Keywords: compartmentalization
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Articles
Biochem Soc Trans (2019) 47 (5): 1383–1392.
Published: 31 October 2019
... regulatory mechanisms that result in compartmentalized signalling. The use of fluorescent probes to monitor cAMP in intact, living cells have been instrumental in furthering our appreciation of this ancestral and ubiquitous pathway and unexpected details of the nano-architecture of the cAMP signalling...
Articles
Biochem Soc Trans (2016) 44 (2): 562–567.
Published: 11 April 2016
.... It is now apparent that GPCR signalling is restricted to highly organized compartments within the cell, and that GPCRs activate distinct signalling pathways once internalized. A high-resolution understanding of how compartmentalized signalling is controlled will probably provide unique opportunities...
Articles
Biochem Soc Trans (2014) 42 (2): 289–294.
Published: 20 March 2014
... that require clarification. A-kinase-anchoring protein (AKAP) cAMP compartmentalization phosphodiesterase (PDE) platelet protein kinase A (PKA) © The Authors Journal compilation © 2014 Biochemical Society 2014 19 12 2013 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
...Konstantinos Lefkimmiatis Mitochondria are highly dynamic organelles comprising at least three distinct areas, the OMM (outer mitochondrial membrane), the IMS (intermembrane space) and the mitochondrial matrix. Physical compartmentalization allows these organelles to host different functional...
Articles
Biochem Soc Trans (2013) 41 (1): 79–83.
Published: 29 January 2013
... Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization...
Articles
Biochem Soc Trans (2012) 40 (1): 246–250.
Published: 19 January 2012
... and Orai1, to lipid raft regions of the cell membrane [ 27 – 31 ]. The apparent compartmentalization of Ca 2+ -sensitive ACs with sites of SOCE in discrete regions of the plasma membrane is central to the dynamics of Ca 2+ and cAMP interplay, enabling the ACs to respond very rapidly to modest changes...
Articles
Biochem Soc Trans (2007) 35 (5): 931–937.
Published: 25 October 2007
... pools of cAMP close to the effector molecules. The intracellular targeting and compartmentalization of PKA is controlled through association with AKAPs. AKAPs are a structurally diverse family of functionally related proteins that now include more than 50 members when splice variants are included...
Articles
Biochem Soc Trans (2006) 34 (4): 465–467.
Published: 21 July 2006
... The Biochemical Society 2006 A-kinase-anchoring protein (AKAP) cAMP cycling compartmentalization protein kinase A (PKA) In a related study, we used a modified FRET-based PKA activity assay to show that recruitment of PKA and PDE4D3 into the FRET reporter complex generated localized pulses of cAMP...
Articles
Biochem Soc Trans (2006) 34 (4): 502–503.
Published: 21 July 2006
... [ 10 , 11 ]. Studies in progress are focusing on the identification in the PDE3B–PI3Kγ complex of similar enzymes that activating PDE3B might thus explain the kinase-independent function of PI3Kγ. Compartmentalization of Cyclic AMP Signalling: Biochemical Society Focused Meeting held at King's...
Articles
Biochem Soc Trans (2005) 33 (1): 287–290.
Published: 01 February 2005
... of bacterial periplasmic binding proteins and by computational design of the binding pockets of the prototype sensors. compartmentalization fluorescence resonance energy transfer (FRET) imaging metabolites nanosensor subcellular Binding domains need to meet certain criteria when considered...