... the bioactivity of the IL-36 subfamily and its role in the pathogenesis of intestinal diseases such as inflammatory bowel disease, colorectal cancer, gut dysbacteriosis and infection, and proposes that IL-36 may be a target for novel therapeutic strategies to prevent or treat intestinal diseases...

... the emerging cancer-associated function of PME-1 and its potential clinical relevance. 7 6 2016 6 8 2016 9 9 2016 colorectal cancer endometrial cancer glioma LCMT-1 neuroendocrine prostate cancer PTPA Protein phosphorylation is a posttranslational modification (PTM) event...

... as laminopathies. However, a new role for lamin A has been discovered in the progression of a common epithelial cancer. CRC (colorectal cancer) patients expressing lamin A/C in their tumour tissue were found to have a 2-fold greater risk of CRC-related mortality compared with patients with lamin A/C-negative...

...G.G.C. Kuhnle; S.A. Bingham Colorectal cancer is the third most common cancer in developed countries such as the U.K., but incidence rates around the world vary approx. 20-fold. Diet is thought to be a key factor determining risk: red and processed meat, but not white meat or fish, are associated...

... appropriate inhibitors to identify stage-specific events. We have adopted this approach to study a group of benzyl- O - N -acetyl- D -galactosamine analogues in human colorectal cancer cell lines. Exposure to O-glycan inhibitors resulted in the induction of apoptosis, a block in proliferation, accumulation...

...F.R. Saunders; H.M. Wallace Colorectal cancer is one of a number of cancers that may be amenable to prevention. The NSAIDs (non-steroidal anti-inflammatory drugs) have been shown to be effective chemopreventative agents in humans, but their mechanism of action is not clear. The polyamines...

... The Biochemical Society 2005 aberrant DNA methylation CpG island colorectal cancer microsatellite instablilty Colorectal cancer develops as the result of the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic epithelium to colon...

... a colorectal cancer cell line (SW48) to show that the ESR1 CGI is methylated in an allele-specific manner. This provides support for the ‘all or none’ mechanism for methylation of this gene, and shows how age-dependent methylation of the ESR1 CGI leads rapidly to silencing of the gene within the cells...

... of oxidative damage to DNA. However, the full genetic pathway of MAP tumorigenesis has not been elucidated. adenomatous polyposis coli (APC) colorectal cancer familial adenomatous polyposis (FAP) MutYH (MYH) MutYH-associated polyposis (MAP) Current data indicate that the colorectal phenotype...

... (familial adenomatous polyposis), an autosomal syndrome that is characterized by multiple colorectal lesions [ 1 ]. APC is also mutated in the majority of sporadic colorectal cancers, and inactivation of APC is recognized as a key early genetic change in colorectal tumorigenesis. This has given rise...

... on its presence in the extracellular matrix, we decided to investigate DMBT1 expression, location and its mode of secretion during malignant transformation in colorectal cancer. Using human colorectal PC/AA cell lines and tissue sections from individual patients, we have examined the expression of DMBT1...

...S.J. Scherer; E. Avdievich; W. Edelmann Mutations in MMR (DNA mismatch repair) genes underlie HNPCC (hereditary non-polyposis colon cancer) and also a significant proportion of sporadic colorectal cancers. MMR maintains genome stability and suppresses tumour formation by correcting DNA replication...

... a library of O-glycosylation inhibitors based on benzyl- O - N -acetyl- D -galactosamine. These inhibitors were tested with an established series of human colorectal cancer cell lines, which model the adenoma-carcinoma sequence. Cancer cells were incubated with the inhibitors, and examined for cell growth...

... in the ability of APC to bind microtubules and perfom its function as a cytoskeletal regulator. This could contribute indirectly to defects in cell migration and chromosome segregation. The Molecular Biology of Colorectal Cancer: Focused Meeting held at the UBHT Education Centre, Bristol, U.K., 10–11...

... is a highly promising agent for the prevention and/or treatment of cancer. The cellular and molecular mechanisms of CRC (colorectal cancer), which in many ways represent the prototypical case for cancer prevention, have been studied extensively. While dietary and lifestyle factors may have a role...