... with respect to caudal extension and possibly also during gut development. 1 To whom correspondence should be addressed (email fb22@le.ac.uk ). 25 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 anal atresia axial extension Cdx colon cancer gut...

...E.W. Gerner Colon cancer in humans is influenced by both genetic and dietary risk factors. The majority of colon cancers have somatic mutations in the APC (adenomatous polyposis coli) tumour-suppressor gene. Dietary arginine enhances the risk of APC-dependent colon carcinogenesis in mouse models...

...J.M. Coxhead; E.A. Williams; J.C. Mathers HNPCC (hereditary non-polyposis colon cancer) is an autosomal-dominant disorder characterized by early-onset CRC (colorectal cancer). HNPCC is most often associated with mutations in the MMR (mismatch repair) genes hMLH1 , hMSH2 , hMSH6 or hPMS2...

... to butyrate's regulatory ability, and therefore sought to assess the expression profile of butyrate-responsive genes in colon cancer tissue, where the expression of the colonic luminal-membrane butyrate transporter, MCT1 (monocarboxylate transporter 1), is significantly down-regulated. In the present paper, we...

...V. Milovic; L. Turchanowa In colon cancer, the activities of polyamine-synthesizing enzymes and polyamine content are increased 3–4-fold over that found in the equivalent normal colonic mucosa, and polyamines have even been attributed as markers of neoplastic proliferation in the colon. Furthermore...