... tell us about true molecular coevolution [ 33 ]. Nevertheless, the considerable past successes of using covariation/coevolutionary analysis to predict tertiary structure and to identify important functional residues suggests that current methods can serve as valuable tools to suggest leads...

... Schug ( al.schug@fz-juelich.de ) 23 6 2017 30 8 2017 4 9 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 big data analysis coevolution epistasis protein–protein interactions signaling statistical inference...