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Keywords: clonality
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Biochem Soc Trans (2010) 38 (2): 374–379.
Published: 22 March 2010
... review the genetic alterations implicated in disease progression in Barrett's oesophagus and discuss how genetic diversity could arise during tumorigenesis. Three arguments are discussed: a high mutation rate coupled with strong selection, clonal interaction driving progression, and a hitherto...