...Pedro Henrique Imenez Silva; Donald E. Wesson; Carsten A. Wagner Chronic kidney disease (CKD) is characterized by progressive reduction in kidney function and treatments aiming at stabilizing or slowing its progression may avoid or delay the necessity of kidney replacement therapy and the increased...

... of hyperphosphatemia are oral P i binder and dietary P i restriction. Although these options are employed in patients with chronic kidney disease (CKD), they seem inadequate to correct elevated plasma P i levels. In addition, a paradoxical increase in expression of intestinal P i transporter and uptake may occur...