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Biochem Soc Trans (2021) 49 (6): 2767–2776.
Published: 16 November 2021
... recently important discoveries have shed some light on its function and shown that Ki-67 has a major role in the formation of mitotic chromosome periphery compartment, it is associated with protein phosphatase one (PP1) and regulates chromatin function in interphase and mitosis. In this review, we discuss...
Biochem Soc Trans (2021) 49 (5): 1891–1903.
Published: 19 October 2021
.... Recent studies in nematodes suggest that DNA elimination removes all chromosome ends, resolves sex chromosome fusions, and may also promote the birth of novel genes. Programmed DNA elimination processes are diverse among species, suggesting DNA elimination likely has evolved multiple times in different...
Biochem Soc Trans (2020) 48 (6): 2359–2376.
Published: 10 December 2020
... that this conserved chromosomal processing machinery is central to DNA repair pathways and the maintenance of genomic stability in all forms of life. A number of experimental studies have explored this intriguing genome surveillance machinery, yielding significant insights and providing conceptual advances towards...
Biochem Soc Trans (2020) 48 (5): 2089–2100.
Published: 02 October 2020
...Erin E. Cutts; Alessandro Vannini Condensin and cohesin, both members of the structural maintenance of chromosome (SMC) family, contribute to the regulation and structure of chromatin. Recent work has shown both condensin and cohesin extrude DNA loops and most likely work via a conserved mechanism...
Biochem Soc Trans (2020) 48 (5): 2159–2171.
Published: 23 September 2020
...Roger Solé-Soler; Jordi Torres-Rosell The Smc5/6 complex plays essential roles in chromosome segregation and repair, by promoting disjunction of sister chromatids. The core of the complex is constituted by an heterodimer of Structural Maintenance of Chromosomes (SMC) proteins that use ATP...
Biochem Soc Trans (2019) 47 (1): 187–196.
Published: 09 January 2019
... until it differentiates into a stalked cell. Its genome consists in a single circular chromosome whose replication is tightly regulated so that it happens only in stalked cells and only once per cell cycle. Imbalances in chromosomal copy numbers are the most often highly deleterious, if not lethal...
Jeffrey C. Hansen, Mark Connolly, Charles J. McDonald, Anyu Pan, Anna Pryamkova, Kyle Ray, Erik Seidel, Sachiko Tamura, Ryan Rogge, Kazuhiro Maeshima
Biochem Soc Trans (2018) 46 (1): 67–76.
Published: 20 December 2017
...Jeffrey C. Hansen; Mark Connolly; Charles J. McDonald; Anyu Pan; Anna Pryamkova; Kyle Ray; Erik Seidel; Sachiko Tamura; Ryan Rogge; Kazuhiro Maeshima A chromosome is a single long DNA molecule assembled along its length with nucleosomes and proteins. During interphase, a mammalian chromosome exists...
Biochem Soc Trans (2016) 44 (5): 1201–1217.
Published: 19 October 2016
...Bungo Akiyoshi The kinetochore is the macromolecular protein complex that drives chromosome segregation in eukaryotes. Its most fundamental function is to connect centromeric DNA to dynamic spindle microtubules. Studies in popular model eukaryotes have shown that centromere protein (CENP...