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Keywords: chromosome
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Biochem Soc Trans (2019) 47 (3): 839–845.
Published: 12 June 2019
.... Here, we review recent data indicating that the activity of the Escherichia coli lac operon promoter also depends upon its chromosomal location. Factors that affect promoter activity include the binding of nucleoid-associated proteins to neighbouring sequences, supercoiling and the activity...
Biochem Soc Trans (2015) 43 (1): 13–18.
Published: 26 January 2015
... © The Authors Journal compilation © 2015 Biochemical Society 2015 centriole centrosome detachment chromosome mitosis In cycling cells, centrioles are contained within centrosomes, small cytoplasmic organelles, which act as major microtubule-organizing centres (MTOCs) [ 1...
Biochem Soc Trans (2013) 41 (6): 1706–1711.
Published: 20 November 2013
...Susan L. Forsburg Replication stress is a significant contributor to genome instability. Recent studies suggest that the centromere is particularly susceptible to replication stress and prone to rearrangements and genome damage, as well as chromosome loss. This effect is enhanced by loss...
Biochem Soc Trans (2013) 41 (6): 1648–1653.
Published: 20 November 2013
...Hiroshi Sato; Shigeaki Saitoh The kinetochore, which forms on a specific chromosomal locus called the centromere, mediates interactions between the chromosome and the spindle during mitosis and meiosis. Abnormal chromosome rearrangements and/or neocentromere formation can cause the presence...
Biochem Soc Trans (2013) 41 (2): 491–493.
Published: 21 March 2013
... ( andrzej.stasiak@unil.ch ). 24 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 catenane chromatin chromosome DNA knot protein folding recombinase supercoiling topoisomerase The structure and function of DNA and proteins are affected by the topology...
Biochem Soc Trans (2011) 39 (5): 1154–1160.
Published: 21 September 2011
...David Vanneste; Vanessa Ferreira; Isabelle Vernos The bipolar spindle is a highly dynamic structure that assembles transiently around the chromosomes and provides the mechanical support and the forces required for chromosome segregation. Spindle assembly and chromosome movements rely...
Biochem Soc Trans (2011) 39 (2): 606–610.
Published: 22 March 2011
... in overcoming protein–DNA barriers to replication and that may illustrate fundamental aspects of how duplication of protein-bound DNA is underpinned in all organisms. 1 email p.mcglynn@abdn.ac.uk 19 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 chromosome...
Biochem Soc Trans (2010) 38 (2): 395–398.
Published: 22 March 2010
...David J. Sherratt; Lidia K. Arciszewska; Estelle Crozat; James E. Graham; Ian Grainge Escherichia coli FtsK is a septum-located DNA translocase that co-ordinates the late stages of cytokinesis and chromosome segregation. Relatives of FtsK are present in most bacteria; in Bacillus subtilis...
Biochem Soc Trans (2009) 37 (5): 971–975.
Published: 21 September 2009
...Geert J.P.L. Kops Error-free chromosome segregation during cell division relies on chromosome biorientation and mitotic checkpoint activity. A group of unrelated kinases controls various aspects of both processes. The present short review outlines our current understanding of the roles...
Biochem Soc Trans (2009) 37 (5): 976–980.
Published: 21 September 2009
...Dan Liu; Michael A. Lampson Accurate segregation of chromosomes in mitosis requires that spindle microtubules attach sister kinetochores to opposite poles of the mitotic spindle (biorientation). To achieve biorientation of all chromosomes, incorrect attachments are selectively destabilized...
Biochem Soc Trans (2008) 36 (4): 749–753.
Published: 22 July 2008
... the development and exploitation of new visualization methods and reagents and show how they are contributing to the understanding of bacterial structure, chromosome organization, DNA metabolism and their relationship to the cell cycle. 1 To whom correspondence should be addressed (email david.sherratt...
Biochem Soc Trans (2007) 35 (3): 609–611.
Published: 22 May 2007
...A. Zalensky; I. Zalenskaya Elaborate non-random organization of human sperm chromosomes at different structural levels, starting from the DNA packing by protamines up to the higher-order chromosome configuration and nuclear positioning of chromosome territories, has been discovered. Here, we put...
Biochem Soc Trans (2006) 34 (4): 531–534.
Published: 21 July 2006
...C. Mézard Many studies have demonstrated that the distribution of meiotic crossover events along chromosomes is non-random in plants and other species with sexual reproduction. Large differences in recombination frequencies appear at several scales. On a large scale, regions of high and low rates...