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Keywords: cholesterol
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1279–1287.
Published: 14 June 2023
... the different stages of phagocytosis, the lipidome however, remained lesser explored, until the past few years. In this review, we summarize recent efforts towards mapping the physiological roles and functions of three lipid classes, the phosphatidylinositols, cholesterol and sphingolipids during the various...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2455–2463.
Published: 13 September 2021
... that suggest shared small molecule transporter functions of Disp to deplete the plasma membrane of cholesterol and to modulate Hh release in an indirect manner. Correspondence: Kay Grobe ( kgrobe@uni-muenster.de ) 8 7 2021 19 8 2021 26 8 2021 © 2021 The Author(s) 2021...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1685–1694.
Published: 04 August 2021
... factors on how membrane proteins function. Correspondence: Francisco N. Barrera ( fbarrera@utk.edu ) 2 6 2021 15 7 2021 19 7 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cholesterol EphA2 fluorescence...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 775–786.
Published: 05 May 2020
...Sampada Kallol; Christiane Albrecht Cholesterol is a major nutrient required for fetal growth. It is also a precursor for the synthesis of steroid hormones and essential for the development and maturation of fetal organs. During pregnancy, the placenta controls the transport of cholesterol from...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 155–163.
Published: 12 February 2020
... caveolin cholesterol dynamics EHD2 pacsin2 Caveolae are characteristic small (50–80 nm) invaginations of the plasma membrane enriched in cholesterol, sphingolipids, the integral membrane proteins caveolin1–3 (CAV1–3) and peripherally attached proteins such as cavins (cavin1–4), EH-domain...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (2): 517–526.
Published: 01 April 2019
... diseases of cholesterol biosynthesis and metabolism are briefly considered. Correspondence: William J. Griffiths ( w.j.griffiths@swansea.ac.uk ) or Yuqin Wang ( y.wang@swansea.ac.uk ) 30 11 2018 25 2 2019 27 2 2019 © 2019 The Author(s) 2019 This is an open access article...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (4): 999–1006.
Published: 14 July 2017
... tetraspanin revealed a cholesterol-binding site, which provides a strong link to the pathophysiological condition of atherosclerosis. Dysregulation of the inflammatory cascade in autoimmune diseases by endothelial cells is exemplified by the involvement of tetraspanins in multiple sclerosis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 652–658.
Published: 11 April 2016
... cholesterol hydroxycholesterol liver X receptor (LXR) RAR-related orphan receptor gamma t (RORγ) sterol regulatory-element binding protein (SREBP) 7-DHC 7-dehydrocholesterol (25R)26-HC (25R)26-hydroxycholesterol 24S 25-EC, 24S,25-epoxycholesterol 24S-HC 24S-hydroxycholesterol...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 493–498.
Published: 11 April 2016
... contacts, which affect endosome dynamics, are believed to be involved in cholesterol transport. 1 To whom correspondence should be addressed (email Fabien.Alpy@igbmc.fr ). 25 1 2016 © 2016 Authors; published by Portland Press Limited 2016 This work was supported by the Ligue...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 425–430.
Published: 11 April 2016
... between lysosomes and peroxisomes, contain phosphorylated derivatives of phosphatidylinositol known as phosphoinositides. In this mini-review we discuss the involvement and functions of phosphoinositides in membrane contact sites. ceramide cholesterol contact site endoplasmic reticulum...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 631–637.
Published: 11 April 2016
... of DDA reveals the existence of a new metabolic pathway in mammals which lies at the crossroads of cholesterol and HA metabolism and which leads to the production of this metabolic tumour suppressor. 1 Correspondence may be addressed to either author (email marc.poirot@inserm.fr...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 745–751.
Published: 03 August 2015
...Kirsty E. Waddington; Elizabeth C. Jury Plasma membrane lipid rafts are heterogeneous cholesterol and glycosphingolipid (GSL)-enriched microdomains, within which the tight packing of cholesterol with the saturated-acyl chains of GSLs creates a region of liquid-order relative to the surrounding...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 752–757.
Published: 03 August 2015
...Kirsty E. Waddington; Elizabeth C. Jury; Inés Pineda-Torra The liver X receptors (LXRs), LXRα and LXRβ, are transcription factors with well-established roles in the regulation of lipid metabolism and cholesterol homeostasis. In addition, LXRs influence innate and adaptive immunity, including...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 572–578.
Published: 03 August 2015
... pharmacological, biochemical and cell biological research over the years has led to a model of TSPO involvement in mitochondrial cholesterol transport and promotion of steroid synthesis, a model guiding the design of drugs useful in stimulating neurosteroid synthesis and alleviating psychopathological symptoms...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (3): 587–593.
Published: 22 May 2012
...Kirsty J. McLean; Marcus Hans; Andrew W. Munro Cholesterol is an essential molecule for eukaryotic life and is an important precursor for a wide range of physiological processes. Biosynthesis and homoeostasis of cholesterol are complex mechanisms that are tightly regulated and interlinked...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (3): 819–822.
Published: 20 May 2011
..., with the greatest inhibition of PMCA4. Besides, cholesterol blocked the inhibitory effect of Aβ, which is consistent with the lack of any Aβ effect on PMCA4 found in cholesterol-enriched lipid rafts isolated from pig brain. These observations suggest that PMCAs are a functional component of the machinery that leads...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (5): 955–960.
Published: 21 September 2009
.... As a case in point, the concept of lipid rafts has received considerable attention from biologists and biophysicists since the formalization of the hypothesis more than 10 years ago. Today, it is clear that sphingolipid and cholesterol can self-associate into micron-scaled phases in model membranes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1453–1455.
Published: 23 November 2007
... Biochemical Society 2007 agonist atherosclerosis cholesterol endothelial cell macrophage Toll-like receptor (TLR) Initial results with double knockout LDLr −/− TLR2 −/− mice showed that whole body deficiency of TLR2 results in decreased lesion burden after 10 or 14 weeks of consuming a high...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 577–582.
Published: 22 May 2007
... was overcome by the addition of geranylgeranyl pyrophosphate. In addition, Cole et al. [ 8 ] also demonstrated that low levels of both cholesterol and isoprenoids had independent effects on Aβ production. In the light of these results, we investigated the concentration-dependent effect of statins upon BACE...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1110–1113.
Published: 25 October 2006
...C.L. Cummins; D.J. Mangelsdorf The LXRs (liver X receptors) (LXRα and LXRβ) are nuclear hormone receptors that are activated by oxysterols, endogenous oxidative metabolites of cholesterol. These receptors regulate an integrated network of genes that control whole body cholesterol and lipid...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1128–1131.
Published: 25 October 2006
..., including atherosclerosis. Research over the last few years has revealed important roles for PPARs and LXRs in macrophage inflammation and cholesterol homoeostasis with consequences in atherosclerosis development. This review will discuss the role of these transcription factors in the control of cholesterol...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 399–403.
Published: 22 May 2006
...J.E. Vance; B. Karten; H. Hayashi Compared with other organs, the brain is highly enriched in cholesterol. Essentially all cholesterol in the brain is synthesized within the brain; the blood–brain barrier prevents the import of plasma lipoproteins into the brain. Consequently, the brain operates...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 335–339.
Published: 22 May 2006
...F.R. Maxfield; M. Mondal The pathways involved in the intracellular transport and distribution of lipids in general, and sterols in particular, are poorly understood. Cholesterol plays a major role in modulating membrane bilayer structure and important cellular functions, including signal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 343–345.
Published: 22 May 2006
... MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol in vivo . In addition to the MENTAL domain, MLN64 contains a cholesterol-specific START domain [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain]. The START domain...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 392–394.
Published: 22 May 2006
...M. Hölttä-Vuori; E. Ikonen The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. Increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1186–1188.
Published: 26 October 2005
... that are essential under anaerobic conditions. Out of the approx. 4800 non-essential genes represented in the mutant collection, 37 were required for growth under anaerobic conditions. Uptake assays using radiolabelled cholesterol revealed that 16 of these genes are required for cholesterol uptake/transport...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1096–1100.
Published: 26 October 2005
... The Biochemical Society 2005 Alzheimer's disease (AD) amyloid precursor protein (APP) β-site amyloid precursor protein-cleaving enzyme (BACE) cholesterol platelet post-mortem brain protease Proteins in Disease: A Focus Topic at BioScience2005, held at SECC Glasgow, U.K., 17–21 July 2005...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1033–1036.
Published: 26 October 2005
...T.J. Nelson; D.L. Alkon Insulin and cholesterol play important roles in basic metabolic processes in peripheral tissues. Both insulin and cholesterol can also act as signalling molecules in the central nervous system that participate in neuronal function, memory and neurodegenerative diseases...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 712–714.
Published: 26 October 2004
...N.O. Gekara; S. Weiss Listeriolysin O, the major virulent determinant of Listeria monocytogenes , is known for forming pores on cholesterol-rich membranes. In the present study, we reveal its other facet, rafts clustering. By immunofluorescence microscopy, we show...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 79–82.
Published: 01 February 2004
... isotopes in appropriately formulated emulsions are providing valuable new information. apolipoprotein B48 apolipoprotein E atherosclerosis breath test cholesterol chylomicron remnant Abbreviations used: CETP, cholesteryl ester transfer protein; CR, chylomicron remnants; HSPG, heparan...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 65–69.
Published: 01 February 2004
...C.J. Fielding; P.E. Fielding The plasma membrane of mammalian cells consists of microdomains differing in lipid and protein composition. Two distinct classes of cholesterol/sphingolipid microdomain (caveolae and lipid rafts) are assembly points for transmembrane signalling complexes. Recent...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 116–120.
Published: 01 February 2004
..., and in macrophages in atherosclerotic plaques. The physiological role of SR-BI has been tested in vivo by the genetic manipulation of SR-BI levels in mice. Mice lacking SR-BI exhibit impaired hepatic-selective HDL cholesterol uptake and increased atherosclerosis, suggesting that SR-BI is required for hepatic reverse...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 121–123.
Published: 01 February 2004
...E. Ikonen; S. Heino; S. Lusa Caveolae (small plasma membrane invaginations) and their coat proteins, caveolins, have attracted the attention of researchers in diverse fields, including cell biology, cardiovascular and cancer research. The tight association between caveolin and cholesterol governs...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 33–36.
Published: 01 February 2004
...C. Sidera; R. Parsons; B. Austen β-Amyloid, a neurotoxic peptide deposited in the brains of Alzheimer's disease patients, is released by a series of membrane-limited proteolytic events. β-Secretase activity is enhanced by cellular targeting into intracellular cholesterol-rich microdomains, which...
Articles
A. Leikin-Frenkel, A.A Weinbroum, D. Leikin-Gobbi, L. Krupitzky, I. Goldiner, L. Shafat, T. Gilat, F.M. Konikoff
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 131–133.
Published: 01 February 2004
...A. Leikin-Frenkel; A.A Weinbroum; D. Leikin-Gobbi; L. Krupitzky; I. Goldiner; L. Shafat; T. Gilat; F.M. Konikoff Fatty acid–bile acid conjugates (FABACs) were shown recently to have important and multiple effects on cholesterol metabolism. In human fibroblasts, they were found to markedly enhance...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 75–78.
Published: 01 February 2004
... of the fatty acids in the aqueous phase of the lumen. Work by Hoffman and Simmonds [2] advanced this important observation and demonstrated that while micellar solubilization greatly facilitated the uptake of fatty Key words: brush border, cholesterol, intestinal fat absorption, lipid, passive process...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 141–143.
Published: 01 February 2004
...R. Maeba; N. Ueta We have demonstrated a novel antioxidant action of ethanolamine plasmalogens both in protecting cholesterol from oxidation by free radicals and in lowering the oxidizability of membranes, along with the action of scavenging radicals, by the oxygen-uptake method using large...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 397–406.
Published: 01 April 2003
... efficient DNA condensation and subsequently drug delivery (i.e. with DNA as the drug) can be brought about using novel polyamine conjugates. Taking further advantage of the functionalization of specific steroids (e.g. cholesterol and certain bile acids), we have designed and prepared novel fluorescent...
Articles
B.E. Kemp, D. Stapleton, D.J. Campbell, Z.-P. Chen, S. Murthy, M. Walter, A. Gupta, J.J. Adams, F. Katsis, B. van Denderen, I.G. Jennings, T. Iseli, B.J. Michell, L.A. Witters
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (1): 162–168.
Published: 01 February 2003
..., a Biochemical Society-sponsored meeting held at University of Dundee, Scotland, 12–14 September 2002 10 September 2002 Copyright 2003 Biochemical Society 2003 AMP-activated protein kinase metabolism cholesterol exercise fatty acid glucose Abbreviations used: AMPK, AMP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (6): 1091–1095.
Published: 01 November 2002
...J. D. Horton Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP iso-forms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 617–623.
Published: 01 August 2001
... To whom correspondence should be addressed (e-mail PharmacolNat@em.uni-frankfurt.de ) 9 3 2001 © 2001 Biochemical Society 2001 Alzheimer-β amyloid cholesterol fluidity membrane Aβ, β-amyloid AD, Alzheimer's disease DPH, 1,6-diphenylhexa-1,2,3-triene TMA-DPH, trimethylamino...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 594–598.
Published: 01 August 2001
... interfacial region, as well as by the presence of cholesterol in the bilayer. These studies show that bilayer compositional and mechanical variations found in different biological membranes can affect the partitioning of peptides into the bilayer. 1 To whom correspondence should be addressed (e...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 292–297.
Published: 01 May 2001
... cholesterol peroxin phytanic acid pristanic acid Zellweger syndrome DHA, docosahexaenoic acid ER, endoplasmic reticulum 2HPCL, 2-hydroxyphytanoyl-CoA lyase MFP, multifunctional protein PBD, peroxisome biogenesis disorder Pex, peroxin PTS, peroxisome targeting signal RCDP, rhizomelic...
