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Articles

Dispatching plasma membrane cholesterol and Sonic Hedgehog dispatch: two sides of the same coin?

Kristina Ehring, Kay Grobe

Biochem Soc Trans (2021) 49 (5): 2455–2463.

DOI: https://doi.org/10.1042/BST20210918

Published: 13 September 2021

... that suggest shared small molecule transporter functions of Disp to deplete the plasma membrane of cholesterol and to modulate Hh release in an indirect manner. Correspondence: Kay Grobe ( kgrobe@uni-muenster.de ) 8 7 2021 19 8 2021 26 8 2021 © 2021 The Author(s) 2021...

View article titled, Dispatching plasma membrane cholesterol and Sonic Hedgehog dispatch: two sides of the same coin?

Articles

Single-molecule fluorescence vistas of how lipids regulate membrane proteins

Alyssa E. Ward, Yujie Ye, Jennifer A. Schuster, Shushu Wei, Francisco N. Barrera

Biochem Soc Trans (2021) 49 (4): 1685–1694.

DOI: https://doi.org/10.1042/BST20201074

Published: 04 August 2021

... factors on how membrane proteins function. Correspondence: Francisco N. Barrera ( fbarrera@utk.edu ) 2 6 2021 15 7 2021 19 7 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cholesterol EphA2 fluorescence...

View article titled, Single-molecule fluorescence vistas of how lipids regulate membrane proteins

Articles

Materno-fetal cholesterol transport during pregnancy

Sampada Kallol, Christiane Albrecht

Biochem Soc Trans (2020) 48 (3): 775–786.

DOI: https://doi.org/10.1042/BST20190129

Published: 05 May 2020

...Sampada Kallol; Christiane Albrecht Cholesterol is a major nutrient required for fetal growth. It is also a precursor for the synthesis of steroid hormones and essential for the development and maturation of fetal organs. During pregnancy, the placenta controls the transport of cholesterol from...

View article titled, Materno-fetal cholesterol transport during pregnancy

Articles

Keeping in touch with the membrane; protein- and lipid-mediated confinement of caveolae to the cell surface

Madlen Hubert, Elin Larsson, Richard Lundmark

Biochem Soc Trans (2020) 48 (1): 155–163.

DOI: https://doi.org/10.1042/BST20190386

Published: 12 February 2020

... caveolin cholesterol dynamics EHD2 pacsin2 Caveolae are characteristic small (50–80 nm) invaginations of the plasma membrane enriched in cholesterol, sphingolipids, the integral membrane proteins caveolin1–3 (CAV1–3) and peripherally attached proteins such as cavins (cavin1–4), EH-domain...

View article titled, Keeping in touch with the membrane; protein- and lipid-mediated confinement of caveolae to the cell surface

Articles

Oxysterol research: a brief review

William J. Griffiths, Yuqin Wang

Biochem Soc Trans (2019) 47 (2): 517–526.

DOI: https://doi.org/10.1042/BST20180135

Published: 01 April 2019

... diseases of cholesterol biosynthesis and metabolism are briefly considered. Amyotrophic lateral sclerosis (ALS): recent studies of serum/plasma and CSF of patients suffering from ALS have revealed elevated levels of free (non-esterified) cholesterol in CSF from an ALS patient group in comparison...

View article titled, Oxysterol research: a brief review

Includes: Supplementary data

Articles

How tetraspanins shape endothelial and leukocyte nano-architecture during inflammation

Jonas Franz, Marco Tarantola, Christoph Riethmüller

Biochem Soc Trans (2017) 45 (4): 999–1006.

DOI: https://doi.org/10.1042/BST20170163

Published: 14 July 2017

... tetraspanin revealed a cholesterol-binding site, which provides a strong link to the pathophysiological condition of atherosclerosis. Dysregulation of the inflammatory cascade in autoimmune diseases by endothelial cells is exemplified by the involvement of tetraspanins in multiple sclerosis...

View article titled, How tetraspanins shape endothelial and leukocyte nano-architecture during inflammation

Articles

Current trends in oxysterol research

William J. Griffiths, Jonas Abdel-Khalik, Thomas Hearn, Eylan Yutuc, Alwena H. Morgan, Yuqin Wang

Biochem Soc Trans (2016) 44 (2): 652–658.

DOI: https://doi.org/10.1042/BST20150255

Published: 11 April 2016

... cholesterol hydroxycholesterol liver X receptor (LXR) RAR-related orphan receptor gamma t (RORγ) sterol regulatory-element binding protein (SREBP) Oxysterols are oxygenated derivatives of cholesterol or its sterol precursors, e.g. 7-dehydrocholesterol (7-DHC) or desmosterol [ 1 , 2...

View article titled, Current trends in oxysterol research

Articles

Touché! STARD3 and STARD3NL tether the ER to endosomes

Léa P. Wilhelm, Catherine Tomasetto, Fabien Alpy

Biochem Soc Trans (2016) 44 (2): 493–498.

DOI: https://doi.org/10.1042/BST20150269

Published: 11 April 2016

... contacts, which affect endosome dynamics, are believed to be involved in cholesterol transport. 1 To whom correspondence should be addressed (email Fabien.Alpy@igbmc.fr ). 25 1 2016 © 2016 Authors; published by Portland Press Limited 2016 cholesterol endoplasmic reticulum...

View article titled, Touché! STARD3 and STARD3NL tether the ER to endosomes

Articles

Phosphoinositides in membrane contact sites

Camilla Raiborg, Eva M. Wenzel, Nina M. Pedersen, Harald Stenmark

Biochem Soc Trans (2016) 44 (2): 425–430.

DOI: https://doi.org/10.1042/BST20150190

Published: 11 April 2016

...@ulrik.uio.no ). 26 11 2015 © 2016 Authors; published by Portland Press Limited 2016 ceramide cholesterol contact site endoplasmic reticulum phosphatidylserine phosphoinositide The membrane compartments of eukaryotic cells communicate via tubulovesicular carriers that bud from...

View article titled, Phosphoinositides in membrane contact sites

Articles

When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite 1

Marc Poirot, Sandrine Silvente-Poirot

Biochem Soc Trans (2016) 44 (2): 631–637.

DOI: https://doi.org/10.1042/BST20150232

Published: 11 April 2016

... of DDA reveals the existence of a new metabolic pathway in mammals which lies at the crossroads of cholesterol and HA metabolism and which leads to the production of this metabolic tumour suppressor. 1 Correspondence may be addressed to either author (email marc.poirot@inserm.fr...

View article titled, When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite 1

Articles

Manipulating membrane lipid profiles to restore T-cell function in autoimmunity

Kirsty E. Waddington, Elizabeth C. Jury

Biochem Soc Trans (2015) 43 (4): 745–751.

DOI: https://doi.org/10.1042/BST20150111

Published: 03 August 2015

...Kirsty E. Waddington; Elizabeth C. Jury Plasma membrane lipid rafts are heterogeneous cholesterol and glycosphingolipid (GSL)-enriched microdomains, within which the tight packing of cholesterol with the saturated-acyl chains of GSLs creates a region of liquid-order relative to the surrounding...

View article titled, Manipulating membrane lipid profiles to restore T-cell function in autoimmunity

Articles

Liver X receptors in immune cell function in humans

Kirsty E. Waddington, Elizabeth C. Jury, Inés Pineda-Torra

Biochem Soc Trans (2015) 43 (4): 752–757.

DOI: https://doi.org/10.1042/BST20150112

Published: 03 August 2015

...Kirsty E. Waddington; Elizabeth C. Jury; Inés Pineda-Torra The liver X receptors (LXRs), LXRα and LXRβ, are transcription factors with well-established roles in the regulation of lipid metabolism and cholesterol homeostasis. In addition, LXRs influence innate and adaptive immunity, including...

View article titled, Liver X receptors in immune cell function in humans

Articles

Translocator protein: pharmacology and steroidogenesis

Andrew Midzak, Barry Zirkin, Vassilios Papadopoulos

Biochem Soc Trans (2015) 43 (4): 572–578.

DOI: https://doi.org/10.1042/BST20150061

Published: 03 August 2015

... pharmacological, biochemical and cell biological research over the years has led to a model of TSPO involvement in mitochondrial cholesterol transport and promotion of steroid synthesis, a model guiding the design of drugs useful in stimulating neurosteroid synthesis and alleviating psychopathological symptoms...

View article titled, Translocator protein: pharmacology and steroidogenesis

Articles

Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes

Kirsty J. McLean, Marcus Hans, Andrew W. Munro

Biochem Soc Trans (2012) 40 (3): 587–593.

DOI: https://doi.org/10.1042/BST20120077

Published: 22 May 2012

...Kirsty J. McLean; Marcus Hans; Andrew W. Munro Cholesterol is an essential molecule for eukaryotic life and is an important precursor for a wide range of physiological processes. Biosynthesis and homoeostasis of cholesterol are complex mechanisms that are tightly regulated and interlinked...

View article titled, Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes

Articles

Impairment of the activity of the plasma membrane Ca 2+ -ATPase in Alzheimer's disease

Ana M. Mata, María Berrocal, M. Rosario Sepúlveda

Biochem Soc Trans (2011) 39 (3): 819–822.

DOI: https://doi.org/10.1042/BST0390819

Published: 20 May 2011

..., with the greatest inhibition of PMCA4. Besides, cholesterol blocked the inhibitory effect of Aβ, which is consistent with the lack of any Aβ effect on PMCA4 found in cholesterol-enriched lipid rafts isolated from pig brain. These observations suggest that PMCAs are a functional component of the machinery that leads...

View article titled, Impairment of the activity of the plasma membrane Ca 2+ -ATPase in Alzheimer's disease

Articles

Lipid rafts as functional heterogeneity in cell membranes

Daniel Lingwood, Hermann-Josef Kaiser, Ilya Levental, Kai Simons

Biochem Soc Trans (2009) 37 (5): 955–960.

DOI: https://doi.org/10.1042/BST0370955

Published: 21 September 2009

.... As a case in point, the concept of lipid rafts has received considerable attention from biologists and biophysicists since the formalization of the hypothesis more than 10 years ago. Today, it is clear that sphingolipid and cholesterol can self-associate into micron-scaled phases in model membranes...

View article titled, Lipid rafts as functional heterogeneity in cell membranes

Articles

Toll-like receptors in atherosclerosis

P.S. Tobias, L.K. Curtiss

Biochem Soc Trans (2007) 35 (6): 1453–1455.

DOI: https://doi.org/10.1042/BST0351453

Published: 23 November 2007

... Society 2007 agonist atherosclerosis cholesterol endothelial cell macrophage Toll-like receptor (TLR) Pattern-Recognition Receptors in Human Disease: A Biochemical Society Focused Meeting held at Queens' College, University of Cambridge, Cambridge, U.K., 8–10 August 2007. Organized...

View article titled, Toll-like receptors in atherosclerosis

Articles

Regulation of the lipidation of β-secretase by statins

R.B. Parsons, J.K. Farrant, G.C. Price, D. Subramaniam, B.M. Austen

Biochem Soc Trans (2007) 35 (3): 577–582.

DOI: https://doi.org/10.1042/BST0350577

Published: 22 May 2007

... was overcome by the addition of geranylgeranyl pyrophosphate. In addition, Cole et al. [ 8 ] also demonstrated that low levels of both cholesterol and isoprenoids had independent effects on Aβ production. In the light of these results, we investigated the concentration-dependent effect of statins upon BACE...

View article titled, Regulation of the lipidation of β-secretase by statins

Articles

Transcriptional regulation of macrophage cholesterol trafficking by PPARα and LXR

G. Chinetti, J.C. Fruchart, B. Staels

Biochem Soc Trans (2006) 34 (6): 1128–1131.

DOI: https://doi.org/10.1042/BST0341128

Published: 25 October 2006

..., including atherosclerosis. Research over the last few years has revealed important roles for PPARs and LXRs in macrophage inflammation and cholesterol homoeostasis with consequences in atherosclerosis development. This review will discuss the role of these transcription factors in the control of cholesterol...

View article titled, Transcriptional regulation of macrophage cholesterol trafficking by PPARα and LXR

Articles

Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland

C.L. Cummins, D.J. Mangelsdorf

Biochem Soc Trans (2006) 34 (6): 1110–1113.

DOI: https://doi.org/10.1042/BST0341110

Published: 25 October 2006

...C.L. Cummins; D.J. Mangelsdorf The LXRs (liver X receptors) (LXRα and LXRβ) are nuclear hormone receptors that are activated by oxysterols, endogenous oxidative metabolites of cholesterol. These receptors regulate an integrated network of genes that control whole body cholesterol and lipid...

View article titled, Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland

Articles

Endosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet

M. Hölttä-Vuori, E. Ikonen

Biochem Soc Trans (2006) 34 (3): 392–394.

DOI: https://doi.org/10.1042/BST0340392

Published: 22 May 2006

...M. Hölttä-Vuori; E. Ikonen The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. Increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking...

View article titled, Endosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet

Articles

Sterol and lipid trafficking in mammalian cells

F.R. Maxfield, M. Mondal

Biochem Soc Trans (2006) 34 (3): 335–339.

DOI: https://doi.org/10.1042/BST0340335

Published: 22 May 2006

...F.R. Maxfield; M. Mondal The pathways involved in the intracellular transport and distribution of lipids in general, and sterols in particular, are poorly understood. Cholesterol plays a major role in modulating membrane bilayer structure and important cellular functions, including signal...

View article titled, Sterol and lipid trafficking in mammalian cells

Articles

Lipid dynamics in neurons

J.E. Vance, B. Karten, H. Hayashi

Biochem Soc Trans (2006) 34 (3): 399–403.

DOI: https://doi.org/10.1042/BST0340399

Published: 22 May 2006

...J.E. Vance; B. Karten; H. Hayashi Compared with other organs, the brain is highly enriched in cholesterol. Essentially all cholesterol in the brain is synthesized within the brain; the blood–brain barrier prevents the import of plasma lipoproteins into the brain. Consequently, the brain operates...

View article titled, Lipid dynamics in neurons

Articles

MLN64 and MENTHO, two mediators of endosomal cholesterol transport

F. Alpy, C. Tomasetto

Biochem Soc Trans (2006) 34 (3): 343–345.

DOI: https://doi.org/10.1042/BST0340343

Published: 22 May 2006

... MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol in vivo . In addition to the MENTAL domain, MLN64 contains a cholesterol-specific START domain [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain]. The START domain...

View article titled, MLN64 and MENTHO, two mediators of endosomal cholesterol transport

Articles

Saccharomyces cerevisiae , a model to study sterol uptake and transport in eukaryotes

S. Reiner, D. Micolod, R. Schneiter

Biochem Soc Trans (2005) 33 (5): 1186–1188.

DOI: https://doi.org/10.1042/BST0331186

Published: 26 October 2005

... that are essential under anaerobic conditions. Out of the approx. 4800 non-essential genes represented in the mutant collection, 37 were required for growth under anaerobic conditions. Uptake assays using radiolabelled cholesterol revealed that 16 of these genes are required for cholesterol uptake/transport...

View article titled, Saccharomyces cerevisiae , a model to study sterol uptake and transport in eukaryotes

Articles

Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease

J.A. Johnston, W.W. Liu, S.A. Todd, D.T.R. Coulson, S. Murphy, G.B. Irvine, A.P. Passmore

Biochem Soc Trans (2005) 33 (5): 1096–1100.

DOI: https://doi.org/10.1042/BST0331096

Published: 26 October 2005

... in BACE expression, in post-mortem brain tissue and platelets from individuals with AD. © 2005 The Biochemical Society 2005 Alzheimer's disease (AD) amyloid precursor protein (APP) β-site amyloid precursor protein-cleaving enzyme (BACE) cholesterol platelet post-mortem brain protease...

View article titled, Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease

Articles

Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration

T.J. Nelson, D.L. Alkon

Biochem Soc Trans (2005) 33 (5): 1033–1036.

DOI: https://doi.org/10.1042/BST0331033

Published: 26 October 2005

...T.J. Nelson; D.L. Alkon Insulin and cholesterol play important roles in basic metabolic processes in peripheral tissues. Both insulin and cholesterol can also act as signalling molecules in the central nervous system that participate in neuronal function, memory and neurodegenerative diseases...

View article titled, Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration

Articles

Lipid rafts clustering and signalling by listeriolysin O

N.O. Gekara, S. Weiss

Biochem Soc Trans (2004) 32 (5): 712–714.

DOI: https://doi.org/10.1042/BST0320712

Published: 26 October 2004

...N.O. Gekara; S. Weiss Listeriolysin O, the major virulent determinant of Listeria monocytogenes , is known for forming pores on cholesterol-rich membranes. In the present study, we reveal its other facet, rafts clustering. By immunofluorescence microscopy, we show...

View article titled, Lipid rafts clustering and signalling by listeriolysin O

Articles

Chylomicron metabolism

T.G. Redgrave

Biochem Soc Trans (2004) 32 (1): 79–82.

DOI: https://doi.org/10.1042/bst0320079

Published: 01 February 2004

... Society 2004 apolipoprotein B48 apolipoprotein E atherosclerosis breath test cholesterol chylomicron remnant Abbreviations used: CETP, cholesteryl ester transfer protein; CR, chylomicron remnants; HSPG, heparan sulphate proteoglycan; LDL, low-density lipoprotein; LRP, LDL receptor...

View article titled, Chylomicron metabolism

Articles

Membrane cholesterol and the regulation of signal transduction

C.J. Fielding, P.E. Fielding

Biochem Soc Trans (2004) 32 (1): 65–69.

DOI: https://doi.org/10.1042/bst0320065

Published: 01 February 2004

...C.J. Fielding; P.E. Fielding The plasma membrane of mammalian cells consists of microdomains differing in lipid and protein composition. Two distinct classes of cholesterol/sphingolipid microdomain (caveolae and lipid rafts) are assembly points for transmembrane signalling complexes. Recent...

View article titled, Membrane cholesterol and the regulation of signal transduction

Articles

Scavenger receptor class B type I in high-density lipoprotein metabolism, atherosclerosis and heart disease: lessons from gene-targeted mice

B. Trigatti, S. Covey, A. Rizvi

Biochem Soc Trans (2004) 32 (1): 116–120.

DOI: https://doi.org/10.1042/bst0320116

Published: 01 February 2004

..., and in macrophages in atherosclerotic plaques. The physiological role of SR-BI has been tested in vivo by the genetic manipulation of SR-BI levels in mice. Mice lacking SR-BI exhibit impaired hepatic-selective HDL cholesterol uptake and increased atherosclerosis, suggesting that SR-BI is required for hepatic reverse...

View article titled, Scavenger receptor class B type I in high-density lipoprotein metabolism, atherosclerosis and heart disease: lessons from gene-targeted mice

Articles

Caveolins and membrane cholesterol

E. Ikonen, S. Heino, S. Lusa

Biochem Soc Trans (2004) 32 (1): 121–123.

DOI: https://doi.org/10.1042/bst0320121

Published: 01 February 2004

...E. Ikonen; S. Heino; S. Lusa Caveolae (small plasma membrane invaginations) and their coat proteins, caveolins, have attracted the attention of researchers in diverse fields, including cell biology, cardiovascular and cancer research. The tight association between caveolin and cholesterol governs...

View article titled, Caveolins and membrane cholesterol

Articles

Proteolytic cascade in the amyloidogenesis of Alzheimer's disease

C. Sidera, R. Parsons, B. Austen

Biochem Soc Trans (2004) 32 (1): 33–36.

DOI: https://doi.org/10.1042/bst0320033

Published: 01 February 2004

...C. Sidera; R. Parsons; B. Austen β-Amyloid, a neurotoxic peptide deposited in the brains of Alzheimer's disease patients, is released by a series of membrane-limited proteolytic events. β-Secretase activity is enhanced by cellular targeting into intracellular cholesterol-rich microdomains, which...

View article titled, Proteolytic cascade in the amyloidogenesis of Alzheimer's disease

Articles

Faecal sterol output is increased by arachidyl amido cholanoic acid (Aramchol) in rats

A. Leikin-Frenkel, A.A Weinbroum, D. Leikin-Gobbi, L. Krupitzky, I. Goldiner, L. Shafat, T. Gilat, F.M. Konikoff

Biochem Soc Trans (2004) 32 (1): 131–133.

DOI: https://doi.org/10.1042/bst0320131

Published: 01 February 2004

...A. Leikin-Frenkel; A.A Weinbroum; D. Leikin-Gobbi; L. Krupitzky; I. Goldiner; L. Shafat; T. Gilat; F.M. Konikoff Fatty acid–bile acid conjugates (FABACs) were shown recently to have important and multiple effects on cholesterol metabolism. In human fibroblasts, they were found to markedly enhance...

View article titled, Faecal sterol output is increased by arachidyl amido cholanoic acid (Aramchol) in rats

Articles

Enterocyte fatty acid uptake and intestinal fatty acid-binding protein

P. Tso, A. Nauli, C.-M. Lo

Biochem Soc Trans (2004) 32 (1): 75–78.

DOI: https://doi.org/10.1042/bst0320075

Published: 01 February 2004

... Biochemical Society 2004 brush border cholesterol intestinal fat absorption lipid passive process transport protein Abbreviations used: FATP4, fatty acid transporter protein 4; FABP, fatty-acid-binding protein; I-FABP, intestinal FABP; L-FABP, liver FABP; AOFA, anthroyloxy fatty acid...

View article titled, Enterocyte fatty acid uptake and intestinal fatty acid-binding protein

Articles

A novel antioxidant action of ethanolamine plasmalogens in lowering the oxidizability of membranes

R. Maeba, N. Ueta

Biochem Soc Trans (2004) 32 (1): 141–143.

DOI: https://doi.org/10.1042/bst0320141

Published: 01 February 2004

...R. Maeba; N. Ueta We have demonstrated a novel antioxidant action of ethanolamine plasmalogens both in protecting cholesterol from oxidation by free radicals and in lowering the oxidizability of membranes, along with the action of scavenging radicals, by the oxygen-uptake method using large...

View article titled, A novel antioxidant action of ethanolamine plasmalogens in lowering the oxidizability of membranes

Articles

Polyamines and novel polyamine conjugates interact with DNA in ways that can be exploited in non-viral gene therapy

I.S. Blagbrough, A.J. Geall, A.P. Neal

Biochem Soc Trans (2003) 31 (2): 397–406.

DOI: https://doi.org/10.1042/bst0310397

Published: 01 April 2003

... efficient DNA condensation and subsequently drug delivery (i.e. with DNA as the drug) can be brought about using novel polyamine conjugates. Taking further advantage of the functionalization of specific steroids (e.g. cholesterol and certain bile acids), we have designed and prepared novel fluorescent...

View article titled, Polyamines and novel polyamine conjugates interact with DNA in ways that can be exploited in non-viral gene therapy

Articles

AMP-activated protein kinase, super metabolic regulator

B.E. Kemp, D. Stapleton, D.J. Campbell, Z.-P. Chen, S. Murthy, M. Walter, A. Gupta, J.J. Adams, F. Katsis, B. van Denderen, I.G. Jennings, T. Iseli, B.J. Michell, L.A. Witters

Biochem Soc Trans (2003) 31 (1): 162–168.

DOI: https://doi.org/10.1042/bst0310162

Published: 01 February 2003

..., a Biochemical Society-sponsored meeting held at University of Dundee, Scotland, 12–14 September 2002 10 September 2002 Copyright 2003 Biochemical Society 2003 AMP-activated protein kinase metabolism cholesterol exercise fatty acid glucose Abbreviations used: AMPK, AMP...

View article titled, AMP-activated protein kinase, super metabolic regulator

Articles

Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis

J. D. Horton

Biochem Soc Trans (2002) 30 (6): 1091–1095.

DOI: https://doi.org/10.1042/bst0301091

Published: 01 November 2002

...J. D. Horton Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP iso-forms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids...

View article titled, Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis

Articles

Membrane-disordering effects of β-amyloid peptides

W. E. Müller, C. Kirsch, G. P. Eckert

Biochem Soc Trans (2001) 29 (4): 617–623.

DOI: https://doi.org/10.1042/bst0290617

Published: 01 August 2001

... To whom correspondence should be addressed (e-mail PharmacolNat@em.uni-frankfurt.de ) 9 3 2001 © 2001 Biochemical Society 2001 Alzheimer-β amyloid cholesterol fluidity membrane Aβ, β-amyloid AD, Alzheimer's disease DPH, 1,6-diphenylhexa-1,2,3-triene TMA-DPH, trimethylamino...

View article titled, Membrane-disordering effects of β-amyloid peptides

Articles

The energetics of binding of a signal peptide to lipid bilayers: the role of bilayer properties

T. J. McIntosh, A. Vidal, S. A. Simon

Biochem Soc Trans (2001) 29 (4): 594–598.

DOI: https://doi.org/10.1042/bst0290594

Published: 01 August 2001

... interfacial region, as well as by the presence of cholesterol in the bilayer. These studies show that bilayer compositional and mechanical variations found in different biological membranes can affect the partitioning of peptides into the bilayer. 1 To whom correspondence should be addressed (e...

View article titled, The energetics of binding of a signal peptide to lipid bilayers: the role of bilayer properties

Articles

Further insights into peroxisomal lipid breakdown via α- and β -oxidation

P. P. Van Veldhoven, M. Casteels, G. P. Mannaerts, M. Baes

Biochem Soc Trans (2001) 29 (2): 292–297.

DOI: https://doi.org/10.1042/bst0290292

Published: 01 May 2001

... cholesterol peroxin phytanic acid pristanic acid Zellweger syndrome DHA, docosahexaenoic acid ER, endoplasmic reticulum 2HPCL, 2-hydroxyphytanoyl-CoA lyase MFP, multifunctional protein PBD, peroxisome biogenesis disorder Pex, peroxin PTS, peroxisome targeting signal RCDP, rhizomelic...

View article titled, Further insights into peroxisomal lipid breakdown via α- and β -oxidation

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