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Keywords: chimeric antigen receptor
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Biochem Soc Trans (2016) 44 (3): 951–959.
Published: 09 June 2016
...Cor H.J. Lamers; Yarne Klaver; Jan W. Gratama; Stefan Sleijfer; Reno Debets We studied safety and proof of concept of a phase I/II trial with chimeric antigen receptor (CAR) T-cells in patients with metastatic renal cell carcinoma (mRCC). The CAR was based on the G250 mAb that recognized an epitope...
Biochem Soc Trans (2016) 44 (2): 397–405.
Published: 11 April 2016
..., hypercalcaemia and bone lesions. Despite recent improvements MM still remains an incurable disease. Previous studies have shown that the adoptive transfer of autologous T-cells modified to express chimeric antigen receptors (CAR) is effective in cases of acute and chronic lymphoid leukaemia. However...
Biochem Soc Trans (2016) 44 (2): 342–348.
Published: 11 April 2016
... responses, compared to polyclonal Tregs. This mini review outlines where Treg therapy currently stands and discusses the approaches which may be taken to generate antigen-specific Tregs, including the potential use of chimeric antigen receptors (CARs), for future clinical trials. 1 Correspondence may...
Biochem Soc Trans (2016) 44 (2): 349–355.
Published: 11 April 2016
...Lynsey M. Whilding; Sabari Vallath; John Maher Immunotherapy of cancer using chimeric antigen receptor (CAR) T-cells is a rapidly expanding field. CARs are fusion molecules that couple the binding of a tumour-associated cell surface target to the delivery of a tailored T-cell activating signal. Re...