... cancer-linked 2HG producing IDH variants, are approved for clinical use in the treatment of chemotherapy-resistant AML, though resistance enabled by additional substitutions has emerged. In this review, we provide a current overview of cancer linked IDH mutations focussing on their distribution...

...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cancer chemotherapy resistance functional genomics genetics When we think about evolution we tend to consider selection acting at the level of the organism, but in cancer, these selective pressures operate...