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Keywords: chemotherapy
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Articles
Biochem Soc Trans (2022) 50 (4): 1119–1128.
Published: 28 July 2022
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . BCL-2 proteins cancer cell death chemotherapy The BCL-2 family proteins are key-regulators of the intrinsic apoptotic pathway. Members of this family contain BCL-2 homology (BH...
Articles
Biochem Soc Trans (2020) 48 (5): 1831–1841.
Published: 01 September 2020
... dimerization which has emerged as an important step in the allosteric regulation of RAS function. allosteric inhibitor cancer chemotherapy dimerization monobody RAS GTPase RAS has been at the forefront of cancer research due to its prominence in the onset and progression of human cancers...
Articles
Biochem Soc Trans (2014) 42 (6): 1608–1615.
Published: 17 November 2014
... chemotherapy combination therapy immunotherapy photodynamic therapy radiotherapy tyrosine kinase inhibitors Angiogenesis inhibitors have firmly entered the current clinical practice for treatment of cancer [ 1 – 3 ]. Many of these agents, such as bevacizumab/Avastin®, sunitinib/Sutent®...
Articles
Biochem Soc Trans (2014) 42 (4): 939–944.
Published: 11 August 2014
... profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma N. Engl. J. Med. 2002 346 1937 1947 10.1056/NEJMoa012914 12075054 32 Monti S. Savage K.J. Kutok J.L. Feuerhake F. Kurtin P. Mihm M. Wu B. Pasqualucci L. Neuberg D. Aguiar...
Articles
Biochem Soc Trans (2007) 35 (5): 1342–1346.
Published: 25 October 2007
... with increased sensitivity to DNA damage-based chemotherapy and resistance to spindle poisons. 1 To whom correspondence should be addressed (email d.harkin@queens-belfast.ac.uk ). 18 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 breast-cancer susceptibility...
Articles
Biochem Soc Trans (2004) 32 (6): 916–917.
Published: 26 October 2004
..., such as cell-cycle control, apoptosis signalling and DNA repair can frequently become epigenetically silenced and methylated in tumours. This may lead to differences in intrinsic sensitivity of tumours to chemotherapy, depending on the specific function of the gene inactivated. Furthermore, chemotherapy itself...
Articles
Biochem Soc Trans (2004) 32 (6): 1087–1089.
Published: 26 October 2004
... total NF-κB inhibition. 1 To whom correspondence should be addressed (email k.j.campbell@dundee.ac.uk ). 5 7 2004 © 2004 The Biochemical Society 2004 chemotherapy nuclear factor κB (NF-κB) post-translational modification RelA transcription UV light NF-κB...
Articles
Biochem Soc Trans (2004) 32 (6): 936–939.
Published: 26 October 2004
... in tumours could lead to improved cancer diagnosis, choice of therapy and, ultimately, development of new drugs. 1 email n.d.perkins@dundee.ac.uk 12 6 2004 © 2004 The Biochemical Society 2004 ADP-ribosylation factor (ARF) chemotherapy DNA damage p53 RelA UV light NF-κB...
Articles
Biochem Soc Trans (2003) 31 (2): 393–396.
Published: 01 April 2003
... 2003 Biochemical Society 2003 cancer chemotherapy inhibitor putrescine spermidine spermine Abbreviations used: DFMO, α-difluoromethylornithine; ODC, ornithine decarboxylase; ADOMETDC, S -adenosylmethionine decarboxylase; SSAT, spermidine/spermine N 1 -acetyltransferase; BENSpm...