... characteristics for chemopreventive and combination anticancer strategies, warranting substantial research effort into harnessing the biological activities of these agents in disease prevention and treatment. However, this requires further investigation into their mode of action and novel approaches...

..., are promising chemopreventive agents against cancer. Compared with their parent compounds, NO-NSAIDs are up to several hundred times more potent in inhibiting the growth of cancer cell lines and prevent colon and pancreatic cancer in animal models. Their chemopreventive effect is due to inhibition...

... (email h.m.wallace@abdn.ac.uk ). 10 1 2007 © 2007 The Biochemical Society 2007 chemoprevention colorectal cancer cytotoxicity non-steroidal anti-inflammatory drug (NSAID) polyamine Colorectal cancer is currently the most commonly diagnosed cancer in the European Union...

... four E-prostanoid receptors (EP1–4). COX-2 has therefore become a target for the potential chemoprevention and therapy of colorectal cancer. However, any therapeutic/preventive strategy has the potential to have an impact on physiological processes and hence result in side effects. General COX (COX-1...