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Keywords: chemokine mutant
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Biochem Soc Trans (2006) 34 (3): 435–437.
Published: 22 May 2006
... chemokine mutants with improved GAG binding affinity and knocked-out GPCR activity. These recombinant proteins displace their wild-type chemokine counterparts from the natural proteoglycan co-receptors without being able to activate leucocytes via GPCRs. Our mutant chemokines therefore represent the first...