...Cinzia Cancellieri; Alessandro Vacchini; Massimo Locati; Raffaella Bonecchi; Elena M. Borroni ACRs (atypical chemokine receptors) were initially referred to as ‘silent’ receptors on the basis of a lack of signalling and functional activities that are typically observed with conventional chemokine...

... CXCR3-A), has allowed a better understanding of how CXC chemokine activity is exerted [ 24 ]. CXCL4L1 (CXCL4-like 1), an ELR (Glu-Leu-Arg)-negative chemokine, has been described as strongly inhibiting angiogenesis [ 25 ]. Mature CXCL4L1 is highly homologous with CXCL4 and only differs by three amino...

... in the destabilization of this plaque. Cellular and molecular approaches are studied by in vitro assay of activated endothelial cells and in in vivo models of neovascularization. Chemokines are a large family of small secreted proteins that have been shown to play a critical role in the regulation of angiogenesis during...

... is not necessary. Systemic inflammatory mediators are also likely to be good candidates as biomarkers due to their sensitivity to injury and ease of measurement. Notably, the CXC chemokine, IL-8, has shown promise as an early marker of prognosis in traumatic brain injury [ 25 ]. An extensive list of putative...

...J.S. Oak; M.P. Matheu; I. Parker; M.D. Cahalan; D.A. Fruman The PI3K (phosphoinositide 3-kinase) family of lipid kinases regulate cell motility in diverse organisms and cell types. In mammals, the main PI3K enzyme activated by chemokine receptor signalling is the class IB isoform, p110γ. Studies...

...-associated adenocarcinoma in IL-10 −/− mice. TLR4-dependent chemokine induction may play a part in modulating the development of colitis-associated neoplasia through altered leucocyte recruitment. 1 To whom correspondence should be addressed (email dmmccaff@ucalgary.ca ). 3 7 2007 ©...

... t.lawrence@imperial.ac.uk ). 1 11 2006 © 2007 The Biochemical Society 2007 adaptive immunity chemokine dendritic cell (DC) inflammation inhibitor of nuclear factor κB kinase (IKK) nuclear factor κB (NF-κB) CCL19 CC chemokine ligand 19 CD40L CD40 ligand DC...

...L. Smith; A. Webb; S.G. Ward The co-ordinated and directional trafficking of T-lymphocytes in lymphoid and peripheral tissues is an important process in lymphoid development, immunosurveillance and immune responses. Members of the chemokine superfamily play a key role in providing navigational cues...

...P. Proost; S. Struyf; J. Van Damme Chemokines, adhesion molecules, cytokines and proteases regulate the extravasation of leucocytes during acute and chronic inflammation and leucocyte homing. Chemokines are produced after transcriptional activation by inflammatory mediators such as cytokines...

...M. Pruenster; A. Rot Chemokines play a key role in directing and driving leucocyte trafficking. The efficient regulation of leucocyte recruitment by chemokines requires their appropriate localization in functional micro-anatomical domains, as well as setting limits to their effects in space...

...A.E.I. Proudfoot Chemokines exert their biological activity through high-affinity interactions with cell-surface receptors, thereby activating specific signalling pathways, and a second low-affinity interaction with proteoglycans. Proteoglycans consist of a protein core, to which GAG...

... microscopy using a Leica TCS confocal microscope (Leica Microsystems, Exton, PA, U.S.A.) (see Table 1 ). 1 To whom correspondence should be addressed (email amaclean@tulane.edu ). 19 7 2004 © 2004 The Biochemical Society 2004 blood–brain barrier chemokine chemotaxis...

... kDa fragment (amino acids 495–609). Immunological functions of these three different domains in stimulating monocytes and dendritic cells have not been fully defined. However, the C-terminal portion (amino acids 359–610) stimulates the production of CC chemokines, IL-12 (interleukin-12), TNFα(tumour...

...Z. Johnson; C.A. Power; C. Weiss; F. Rintelen; H. Ji; T. Ruckle; M. Camps; T.N.C. Wells; M.K. Schwarz; A.E.I. Proudfoot; C. Rommel Chemokines are small chemoattractant cytokines that control a wide variety of biological and pathological processes, ranging from immunosurveillance to inflammation...