... and the Biochemical Society under a transformative agreement with Individual. biosensors chemical biology fluorescence microscopy fluorescent proteins protein engineering signaling The 1994 demonstration that the green fluorescent protein (GFP) could be recombinantly and functionally expressed...

.... alt-protein chemical biology microprotein proteogenomics proteomics smORF Due to their short lengths, SEPs and alt-proteins typically only generate one, or few, detectable tryptic peptides for liquid chromatography–tandem mass spectrometry (LC–MS/MS) detection, whereas larger proteins...

...-translational modification. Perturbation to these networks leads to genomic instability and disease, presenting epigenetic proteins as key therapeutic targets. This mini-review will describe progress in mapping the combinatorial histone PTM landscape, and recent chemical biology approaches to map histone...

... and might represent a treasure trove of novel therapeutic opportunities. chemical biology drug discovery protein tyrosine phosphatase © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 3 6 2021 28 7 2021 30 7 2021...

... the Creative Commons Attribution License 4.0 (CC BY) . Open access for this article was enabled by the participation of University of York in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. chemical biology chemical...

... was enabled by the participation of University of Groningen in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. antimicrobials bacteria chemical biology NRPS RiPPs synthetic biology The rising emergence of multi-drug resistant bacterial pathogens...

... by NNMT and cellular export mechanisms. Correspondence: Marie E. Migaud ( mmigaud@health.southalabama.edu ) 26 8 2018 14 10 2018 17 10 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 chemical biology metabolome...

...Joanna M. Swarbrick; Andrew M. Riley; Stephen J. Mills; Barry V.L. Potter Synthetic compounds open up new avenues to interrogate and manipulate intracellular Ca 2+ signalling pathways. They may ultimately lead to drug-like analogues to intervene in disease. Recent advances in chemical biology tools...