...João M. N. Duarte The pathophysiological mechanisms intersecting metabolic and neurodegenerative disorders include insulin resistance, which has a strong involvement of environmental factors. Besides central regulation of whole-body homeostasis, insulin in the central nervous system controls...

... development, neurodegenerative disorders, psychopathologies and brain cancers. Glycan structures are diverse and complex; however, they have been detected and targeted in the central nervous system (CNS) by various immunohistochemical detection methods using glycan-binding proteins such as anti-glycan...

...Jane E. Hewitt During the last 10 years it has become apparent that a significant subset of inherited muscular dystrophy is caused by errors in the glycosylation of α-dystroglycan. Many of these dystrophies are also associated with abnormalities of the central nervous system. Dystroglycan has...

...J.A. Green; J.S. Friedland The CNS (central nervous system) has a unique pattern of immune response to infection. TB (tuberculosis) of the CNS is devastating with widespread tissue destruction. In TB, astrocyte–leucocyte interactions are key in regulating MMP (matrix metalloproteinase) activity...

... to be addressed (email joerg.striessnig@uibk.ac.at ). 22 7 2006 © 2006 The Biochemical Society 2006 brain function Ca 2+ channel cardiovascular disease central nervous system dihydropyridine voltage-gated L-type Ca 2+ channel VGCCs (voltage-gated Ca 2+ channels) are key...

... that is observed in the ME7 model. It may therefore contribute to the reactive gliosis that is characteristic of prion diseases. 1 To whom correspondence should be addressed (email bcg198@soton.ac.uk ). 20 9 2005 © 2006 The Biochemical Society 2006 μ-calpain central nervous system...

...: a growth cone extends short distances towards sequential guidepost cells before it reaches its final destination in the target tissue or brain. There Key words: nervous system development, survival, central nervous system, peripheral nervous system. Abbreviations used: CNS, central nervous system; PNS...

...T. Teesalu; A. Kulla; T. Asser; M. Koskiniemi; A. Vaheri Tissue plasminogen activator (tPA) is expressed by many types of neurons in the developing and adult rodent brain. We have now mapped tPA transcripts and protein in the human central nervous system using tissue arrays and find widespread...

...D. v. Agoston; A. Dobi The gene for enkephalin is expressed only in specific subsets of neurons in the mammalian central nervous system (CNS), whereas the large majority of neurons do not express the gene. This restricted expression is the result of a developmental process during which some...