... Biochemical Society 2014 ABL1 angiogenesis cell signalling neuropilin-1 oxygen-induced retinopathy paxillin Neuropilin-1 (NRP1) plays a central role in endothelial cells (ECs). Loss of NRP1 in mouse embryos reduces angiogenesis in the brain and spinal cord and leads to embryonic lethality...

.../by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. antioxidant response cancer cell signalling degradation drug design ubiquitylation Specific patterns of mono- or poly-ubiquitylation are used by the cell...

... signals, while interconnectivities between pathways lead to an enhanced complexity of regulatory responses that enable sophisticated adaptation. In principle, any cell signalling pathway may be rewired to respond to non-cognate signals by exchanging and recombining their underlying cognate signalling...

..., and it is becoming increasingly recognized that cellular adaptations result from the quantitative integration of multi-pathway network activities, rather than isolated pathways causing particular phenotypes. Therefore comprehending liver cell signalling in inflammation requires a scientific approach...

... of lipidomics (driven in part by innovations in MS-based analysis), the acceleration of new insights into the role of oxidative protein modifications (particularly to cysteine residues) in modulating cell signalling, and the effects of free radicals on the functions of mitochondria, extracellular matrix...

... dichlorodihydrofluorescein or dihydrorhodamine. 1 email balarama@mcw.edu . 15 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell signalling fluorescence mitochondrion reactive nitrogen species (RNS) reactive oxygen species (ROS) redox biology superoxide...

... Society 2011 activating transcription factor 4 (ATF4) acute myeloid leukaemia (AML) cell signalling genome-wide association study (GWAS) mitogen-activated protein kinase (MAPK) tribbles Tribbles (trb) proteins have been discovered and characterized as a key protein family in the regulation...

... ). 10 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cell signalling inhibitory κB (IκB) inhibitory κB kinase (IKK) nuclear factor-κB (NF-κB) post-translational modification ubiquitin-like protein The NF-κB (nuclear factor κB) pathway is the conduit...

.... 1 To whom correspondence should be addressed (email cjefferies@rcsi.ie ). 18 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 antiviral response cell signalling interferon regulatory factor (IRF) Toll-like receptor type I interferon ubiquitination...

... for more answers. 1 To whom correspondence should be addressed (email m.falasca@ucl.ac.uk ). 23 10 2006 © 2007 The Biochemical Society 2007 cell signalling lysophosphatidic acid phosphoinositide 3-kinase (PI3K) phosphatidylinositol 3,4,5-trisphosphate PI3Ks...

... binding of cAMP to the Rap1 GEF EPAC [ 14 – 16 ]. © 2004 The Biochemical Society 2004 cell signalling endocytosis G-protein-coupled receptor small G-protein trafficking Heterotrimeric GPCRs (G-protein-coupled receptors) form the largest group of integral membrane receptor proteins...

... of the integration of cell signalling will probably reflect many functions performed by members of the AKAP family. 1 To whom correspondence should be addressed (email craig@pharm.sunysb.edu ). 6 7 2004 © 2004 The Biochemical Society 2004 A-kinase anchoring protein (AKAP) AKAP250 cell...

... 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 30 April 2003 © 2003 Biochemical Society 2003 aspartic protease cell signalling endoplasmic reticulum protein translocation signal peptide peptidase Abbreviations used...

... correspondence should be addressed (e-mail wmb.whe@cf.ac.uk ) 2 3 2001 © 2001 Biochemical Society 2001 cell interactions cell signalling gap junction inhibitors GJIC, gap-junctional intercellular communication Biochemical Society Transactions (200 I) Volume 29, part 4 24 Sipe, J. D...