...Airah Javorsky; Patrick O. Humbert; Marc Kvansakul Scribble is a scaffolding protein that regulates key events such as cell polarity, tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise of 16 Leucine Rich Repeats (LRR) at the N-terminus, two LAP Specific Domains...

.... 1 email husem@mskcc.org 17 7 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 actin cell polarity microtubule protein kinase C (PKC) signal transduction T-cell T-cell receptor (TCR) engagement of cognate peptide–major histocompatibility...

...Xu Chen; Jiří Friml ROPs (Rho of plants) belong to a large family of plant-specific Rho-like small GTPases that function as essential molecular switches to control diverse cellular processes including cytoskeleton organization, cell polarization, cytokinesis, cell differentiation and vesicle...

...Maitreyi Das; Fulvia Verde Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self...

... © The Authors Journal compilation © 2011 Biochemical Society 2011 cell cycle cell polarity inner nuclear membrane nuclear envelope retinoblastoma protein Tmem53 The NE (nuclear envelope) is a highly organized double-membrane system sequestering the nuclear contents from...

... proteins and lipids differ from those of the basolateral on these embryonic epithelial cells, as is found in adult epithelial cells. Formation of cell polarity in embryos at fertilization, including those from both protostomes and deuterostomes, uses the same molecules and signalling machinery as do...

... ). 5 11 2006 © 2007 The Biochemical Society 2007 cancer cell polarity diabetes Drosophila lipogenesis nutrient sensing For some years, the PI3K (phosphoinositide 3-kinase)/Akt signalling cassette has been recognized as a major regulatory pathway for growth and metabolism...

... and the Drosophila homologue Crumbs. In the present study, we review the current knowledge on Crumbs and its vertebrate homologues, their function in cell polarity and their pathogenicity in retinal degeneration. The Crumbs/CRB1 function has most extensively been studied in Drosophila . In Drosophila embryonic...