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Keywords: cell migration
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Biochem Soc Trans (2021) 49 (4): 1515–1527.
Published: 10 August 2021
... on mitosis and cell migration, as well as discuss potential productive future research avenues that might reveal novel insights into the overall dynamics of the pathway. Figure 1. Regulation of mitosis by the Hippo pathway and YAP/TAZ. ( A ) Upstream Hippo pathway serine/threonine kinases control...
Biochem Soc Trans (2020) 48 (2): 419–428.
Published: 02 April 2020
...Björn Stinner; Till Bretschneider Directed cell migration poses a rich set of theoretical challenges. Broadly, these are concerned with (1) how cells sense external signal gradients and adapt; (2) how actin polymerisation is localised to drive the leading cell edge and Myosin-II molecular motors...
Biochem Soc Trans (2019) 47 (3): 811–826.
Published: 07 May 2019
...Valentina Gifford; Yoshifumi Itoh Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety...
Biochem Soc Trans (2017) 45 (3): 771–779.
Published: 15 June 2017
... work into the function of APPL1 in cell migration and adhesion. Signaling endosomes are believed to function as platforms for integrating distinct communication pathways within cells [ 1 ]. Endosome-associated adaptor proteins are critical in mediating this cross-talk between signaling pathways...
Biochem Soc Trans (2017) 45 (1): 229–236.
Published: 15 February 2017
... remodeling of the stromal extracellular matrix (ECM) by CAFs are important contributors to tumor cell migration and invasion, which are critical for cancer progression from a primary tumor to metastatic disease. In this review, we discuss key paracrine signaling pathways between CAFs and cancer cells...
Biochem Soc Trans (2016) 44 (6): 1695–1700.
Published: 02 December 2016
...Joseph H.R. Hetmanski; Jean-Marc Schwartz; Patrick T. Caswell Metastasis, initially driven by cells migrating and invading through the local environment, leads to most cancer-associated deaths. Cells can use a variety of modes to move in vitro , all of which depend on Rho GTPases at some level...
Biochem Soc Trans (2015) 43 (1): 84–91.
Published: 26 January 2015
... the arrangement of actin at the comet tail–pathogen interface. The comet tails were too thick and the actin filaments were too densely packed for their arrangement to be resolved by conventional 2D imaging. actin cell migration cytoskeleton electron tomography propulsion Actin filaments perform...
Biochem Soc Trans (2015) 43 (1): 79–83.
Published: 26 January 2015
... summarize the current knowledge on kinesin functions in cell migration. 1 To whom correspondence should be addressed (email anne@mechanochemistry.org ) . 16 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 cell adhesion cell migration force generation...
Biochem Soc Trans (2015) 43 (1): 129–132.
Published: 26 January 2015
... that macropinocytosis and cell migration are negatively correlated. Heavy drinkers move only slowly and vice versa, fast cells do not take big gulps. Both processes are balanced by the lipid phosphatidylinositol 3,4,5-trisphosphate (PIP 3 ). Elevated PIP 3 signalling causes a shift towards macropinocytosis and inhibits...
Biochem Soc Trans (2014) 42 (5): 1356–1366.
Published: 18 September 2014
... compilation © 2014 Biochemical Society 2014 actin cell migration cell plasticity collagen melanoma The induction of filopod-like leading protrusions resulted from fibrillar organization of collagen ligand, irrespective of whether cells were confronted with 2D or 3D fibrillar collagen...
Includes: Supplementary data
Biochem Soc Trans (2011) 39 (5): 1166–1168.
Published: 21 September 2011
... through Rho and ROCK signalling. Myo9b localizes to dynamic F-actin at the extending cell front and regulates Rho signalling. Thereby it controls cell polarity and cell migration of macrophages. Myo9b-deficient mice on average are ~10% lighter than wt (wild-type) mice, but have no obvious...
Biochem Soc Trans (2011) 39 (5): 1131–1135.
Published: 21 September 2011
... as chimaeric forms of NM II (II-A head and II-B tail and vice versa) to substitute for NM II-A in cell–cell adhesions in II-A-ablated mice. However, we also show that certain functions, such as neuronal cell migration in the developing brain and vascularization of the mouse embryo and placenta, specifically...
Biochem Soc Trans (2009) 37 (5): 1072–1076.
Published: 21 September 2009
... on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling. Although internalization of plasma membrane proteins appears to be an integral...
Biochem Soc Trans (2007) 35 (2): 193–198.
Published: 20 March 2007
... by chemokines in T-lymphocytes is the activation of several members of the PI3K (phosphoinositide 3-kinase) family. In many cell systems, PI3Ks are known to contribute to several aspects of the migratory machinery, although their role in T-cell migration has been unclear and will be considered in the present...
Biochem Soc Trans (2005) 33 (6): 1507–1508.
Published: 26 October 2005
.... Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN...
Biochem Soc Trans (2004) 32 (6): 1110–1112.
Published: 26 October 2004
... largely remain unknown. BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains serving as a homophilic/heterophilic interaction device, an enzymic RhoGAP domain that inactivates RhoA and a proline-rich region...
Biochem Soc Trans (2004) 32 (3): 431–433.
Published: 01 June 2004
...: a Biochemical Society Focused Meeting held at Chancellors Conference Centre, University of Manchester, 1–3 December 2003 3 December 2003 © 2004 Biochemical Society 2004 actin cytoskeleton cell migration fluorescence lifetime imaging microscopy (FLIM) fluorescence resonance energy...
Biochem Soc Trans (2002) 30 (6): 959–963.
Published: 01 November 2002
..., interleukin-6 and interferon-γ, at the level of mRNA stability and translation. In the case of TNF-α, this regulation depends on the AU-rich element in TNF-α mRNA. In addition to cytokine expression, MK2 is also essential for cell migration in vitro. Although the role of MK2 in cytokine expression depends...
Biochem Soc Trans (2002) 30 (2): 102–107.
Published: 01 April 2002
..., extracellular matrix EIIIA, exon IIIA EIIIB, exon IIIB, MMP, matrix metalloproteinase PDGF, platelet-derived growth factor VSMC, vascular smooth muscle cells cell migration 3/4 collagen fragment exon IIIA exon IIIB Biochemical Society Transactions (2002) Volume 30, part 2 teinases and asking...