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Keywords: cell migration
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Biochem Soc Trans (2023) BST20220221.
Published: 25 January 2023
...Florian Fäßler; Manjunath G. Javoor; Florian KM Schur The actin cytoskeleton plays a key role in cell migration and cellular morphodynamics in most eukaryotes. The ability of the actin cytoskeleton to assemble and disassemble in a spatiotemporally controlled manner allows it to form higher-order...
Biochem Soc Trans (2021) 49 (4): 1515–1527.
Published: 10 August 2021
... on mitosis and cell migration, as well as discuss potential productive future research avenues that might reveal novel insights into the overall dynamics of the pathway. cell migration feedback hippo pathway mitosis STRIPAK YAP/TAZ The Hippo pathway was initially identified through genetic...
Biochem Soc Trans (2020) 48 (2): 419–428.
Published: 02 April 2020
...Björn Stinner; Till Bretschneider Directed cell migration poses a rich set of theoretical challenges. Broadly, these are concerned with (1) how cells sense external signal gradients and adapt; (2) how actin polymerisation is localised to drive the leading cell edge and Myosin-II molecular motors...
Biochem Soc Trans (2019) 47 (3): 811–826.
Published: 07 May 2019
...Valentina Gifford; Yoshifumi Itoh Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety...
Biochem Soc Trans (2017) 45 (3): 771–779.
Published: 15 June 2017
... work into the function of APPL1 in cell migration and adhesion. APPL1 integrates signaling cross-talk via multiple domains that mediate protein and lipid interactions [ 3 , 4 ]. The N-terminal BAR (Bin–Amphiphysin–Rvs) domain is implicated in sensing or inducing membrane curvature [ 5 , 6 ], while...
Biochem Soc Trans (2017) 45 (1): 229–236.
Published: 15 February 2017
... remodeling of the stromal extracellular matrix (ECM) by CAFs are important contributors to tumor cell migration and invasion, which are critical for cancer progression from a primary tumor to metastatic disease. In this review, we discuss key paracrine signaling pathways between CAFs and cancer cells...
Biochem Soc Trans (2016) 44 (6): 1695–1700.
Published: 02 December 2016
...Joseph H.R. Hetmanski; Jean-Marc Schwartz; Patrick T. Caswell Metastasis, initially driven by cells migrating and invading through the local environment, leads to most cancer-associated deaths. Cells can use a variety of modes to move in vitro , all of which depend on Rho GTPases at some level...
Biochem Soc Trans (2015) 43 (1): 79–83.
Published: 26 January 2015
... summarize the current knowledge on kinesin functions in cell migration. 1 To whom correspondence should be addressed (email anne@mechanochemistry.org ) . 16 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 cell adhesion cell migration force generation...
Biochem Soc Trans (2015) 43 (1): 129–132.
Published: 26 January 2015
... that macropinocytosis and cell migration are negatively correlated. Heavy drinkers move only slowly and vice versa, fast cells do not take big gulps. Both processes are balanced by the lipid phosphatidylinositol 3,4,5-trisphosphate (PIP 3 ). Elevated PIP 3 signalling causes a shift towards macropinocytosis and inhibits...
Biochem Soc Trans (2015) 43 (1): 84–91.
Published: 26 January 2015
... resolution and cryo-ET for preserving overall 3D morphology was crucial for obtaining a complete structure–function analysis of actin-driven propulsion. 1 email vic.small@imba.oeaw.ac.at 9 7 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 actin cell...
Biochem Soc Trans (2014) 42 (5): 1356–1366.
Published: 18 September 2014
... compilation © 2014 Biochemical Society 2014 actin cell migration cell plasticity collagen melanoma Actin-based cytoskeletal polarization and dynamics are indispensable for cell positioning in tissues and organs during morphogenesis, immune defence and regeneration, and, in its deregulated...
Includes: Supplementary data
Biochem Soc Trans (2011) 39 (5): 1166–1168.
Published: 21 September 2011
.... The differentiation is regulated through Rho and ROCK signalling. Myo9b localizes to dynamic F-actin at the extending cell front and regulates Rho signalling. Thereby it controls cell polarity and cell migration of macrophages. cell migration epithelium macrophage myosin Rho-GAP Rho signalling...
Biochem Soc Trans (2011) 39 (5): 1131–1135.
Published: 21 September 2011
... as chimaeric forms of NM II (II-A head and II-B tail and vice versa) to substitute for NM II-A in cell–cell adhesions in II-A-ablated mice. However, we also show that certain functions, such as neuronal cell migration in the developing brain and vascularization of the mouse embryo and placenta, specifically...
Biochem Soc Trans (2009) 37 (5): 1072–1076.
Published: 21 September 2009
... on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling. We are especially interested in the role of vesicle trafficking pathways in cell...
Biochem Soc Trans (2007) 35 (2): 193–198.
Published: 20 March 2007
... by chemokines in T-lymphocytes is the activation of several members of the PI3K (phosphoinositide 3-kinase) family. In many cell systems, PI3Ks are known to contribute to several aspects of the migratory machinery, although their role in T-cell migration has been unclear and will be considered in the present...
Biochem Soc Trans (2005) 33 (6): 1507–1508.
Published: 26 October 2005
.... Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN...
Biochem Soc Trans (2004) 32 (6): 1110–1112.
Published: 26 October 2004
... largely remain unknown. BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains serving as a homophilic/heterophilic interaction device, an enzymic RhoGAP domain that inactivates RhoA and a proline-rich region...
Biochem Soc Trans (2004) 32 (3): 431–433.
Published: 01 June 2004
..., there are many pitfalls asso- ciated with this method, namely the insensitivity, high back- ground and the signal is entirely determined by the amount of fluorophores present. The alternative technique, routinely Key words: actin cytoskeleton, cell migration, fluorescence lifetime imaging microscopy (FLIM...
Biochem Soc Trans (2002) 30 (6): 959–963.
Published: 01 November 2002
..., interleukin-6 and interferon-γ, at the level of mRNA stability and translation. In the case of TNF-α, this regulation depends on the AU-rich element in TNF-α mRNA. In addition to cytokine expression, MK2 is also essential for cell migration in vitro. Although the role of MK2 in cytokine expression depends...
Biochem Soc Trans (2002) 30 (2): 102–107.
Published: 01 April 2002
..., extracellular matrix EIIIA, exon IIIA EIIIB, exon IIIB, MMP, matrix metalloproteinase PDGF, platelet-derived growth factor VSMC, vascular smooth muscle cells cell migration 3/4 collagen fragment exon IIIA exon IIIB Biochemical Society Transactions (2002) Volume 30, part 2 teinases and asking...