...Hoang Anh Le; Roberto Mayor Physical properties of tissue are increasingly recognised as major regulatory cues affecting cell behaviours, particularly cell migration. While these properties of the extracellular matrix have been extensively discussed, the contribution from the cellular components...

... for this article was enabled by the participation of the University of Cambridge in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. actin dynamics cell migration endocytosis macropinocytosis trafficking...

...Florian Fäßler; Manjunath G. Javoor; Florian KM Schur The actin cytoskeleton plays a key role in cell migration and cellular morphodynamics in most eukaryotes. The ability of the actin cytoskeleton to assemble and disassemble in a spatiotemporally controlled manner allows it to form higher-order...

... on mitosis and cell migration, as well as discuss potential productive future research avenues that might reveal novel insights into the overall dynamics of the pathway. * Lead Contact. 30 3 2021 22 6 2021 23 6 2021 © 2021 The Author(s) 2021 This is an open access article...

...Björn Stinner; Till Bretschneider Directed cell migration poses a rich set of theoretical challenges. Broadly, these are concerned with (1) how cells sense external signal gradients and adapt; (2) how actin polymerisation is localised to drive the leading cell edge and Myosin-II molecular motors...

...Valentina Gifford; Yoshifumi Itoh Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety...

... work into the function of APPL1 in cell migration and adhesion. Signaling endosomes are believed to function as platforms for integrating distinct communication pathways within cells [ 1 ]. Endosome-associated adaptor proteins are critical in mediating this cross-talk between signaling pathways...

... remodeling of the stromal extracellular matrix (ECM) by CAFs are important contributors to tumor cell migration and invasion, which are critical for cancer progression from a primary tumor to metastatic disease. In this review, we discuss key paracrine signaling pathways between CAFs and cancer cells...

...Joseph H.R. Hetmanski; Jean-Marc Schwartz; Patrick T. Caswell Metastasis, initially driven by cells migrating and invading through the local environment, leads to most cancer-associated deaths. Cells can use a variety of modes to move in vitro , all of which depend on Rho GTPases at some level...

... of actin filaments involved in pushing [ 13 , 14 ]. Through the application of ET, the structure of comet tails propelling a baculovirus has now been resolved [ 15 ], providing new insights into the way pathogens exploit the actin polymerization machinery to move. actin cell migration...

... summarize the current knowledge on kinesin functions in cell migration. 1 To whom correspondence should be addressed (email anne@mechanochemistry.org ) . 16 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 cell adhesion cell migration force generation...

... that macropinocytosis and cell migration are negatively correlated. Heavy drinkers move only slowly and vice versa, fast cells do not take big gulps. Both processes are balanced by the lipid phosphatidylinositol 3,4,5-trisphosphate (PIP 3 ). Elevated PIP 3 signalling causes a shift towards macropinocytosis and inhibits...

... substrate geometries. 2 To whom correspondence should be addressed (email P.Friedl@ncmls.ru.nl ) . 14 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 actin cell migration cell plasticity collagen melanoma 1 Present address: Institut für...

... through Rho and ROCK signalling. Myo9b localizes to dynamic F-actin at the extending cell front and regulates Rho signalling. Thereby it controls cell polarity and cell migration of macrophages. Myo9b-deficient mice on average are ~10% lighter than wt (wild-type) mice, but have no obvious...

... as chimaeric forms of NM II (II-A head and II-B tail and vice versa) to substitute for NM II-A in cell–cell adhesions in II-A-ablated mice. However, we also show that certain functions, such as neuronal cell migration in the developing brain and vascularization of the mouse embryo and placenta, specifically...

... on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling. 1 To whom any correspondence should be addressed (email J.rappaport@bham.ac.uk...

... by chemokines in T-lymphocytes is the activation of several members of the PI3K (phosphoinositide 3-kinase) family. In many cell systems, PI3Ks are known to contribute to several aspects of the migratory machinery, although their role in T-cell migration has been unclear and will be considered in the present...

.... Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN...

... largely remain unknown. BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains serving as a homophilic/heterophilic interaction device, an enzymic RhoGAP domain that inactivates RhoA and a proline-rich region...

... fluorescent protein; PAK1, p21-activated kinase-1; PKC, protein kinase C; RFP, red fluorescent protein. actin cytoskeleton cell migration fluorescence lifetime imaging microscopy (FLIM) fluorescence resonance energy transfer (FRET) signalling © 2004 Biochemical Society 2004 3...

..., interleukin-6 and interferon-γ, at the level of mRNA stability and translation. In the case of TNF-α, this regulation depends on the AU-rich element in TNF-α mRNA. In addition to cytokine expression, MK2 is also essential for cell migration in vitro. Although the role of MK2 in cytokine expression depends...

..., extracellular matrix EIIIA, exon IIIA EIIIB, exon IIIB, MMP, matrix metalloproteinase PDGF, platelet-derived growth factor VSMC, vascular smooth muscle cells cell migration 3/4 collagen fragment exon IIIA exon IIIB Biochemical Society Transactions (2002) Volume 30, part 2 teinases and asking...