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Keywords: cell differentiationClose
Biochem Soc Trans (2021) 49 (4): 1803–1816.
Published: 26 August 2021
... spontaneously differentiate into benign cells unable to initiate new tumours [ 32 , 33 ], suggesting reversibility of malignant cell behaviour [ 34 ]. From these pivotal observations has emerged the hypothesis that targeting the cell differentiation machinery may offer a complementary therapeutic approach...
Biochem Soc Trans (2021) 49 (2): 805–814.
Published: 30 April 2021
... with a host of haematopoietic neoplasms [ 4 ] as well as impaired immune system responses [ 5 ]. Figure 1. Haematopoiesis involves the epigenetic silencing of alternate fate genes, reducing multipotency and the self-renewal capacity as cells differentiate. Haematopoietic stem cells (HSC) differentiate...
Biochem Soc Trans (2022) 50 (1): 499–511.
Published: 11 January 2021
... patterning cell differentiation homeobox genes human pluripotent stem cells neural crest cells Human pluripotent stem cells (hPSCs) have become a powerful resource to study embryonic development, circumventing both the technical and ethical obstacles associated with the use of human embryos...
Biochem Soc Trans (2019) 47 (4): 1077–1089.
Published: 27 June 2019
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cell differentiation developmental biology T cells A key attribute of T cell immunity is the expression of a distinct T cell receptor (TCR) on each T cell, which confers individual specificity...
Biochem Soc Trans (2019) 47 (3): 875–885.
Published: 17 June 2019
... of the Biochemical Society 2019 cell differentiation epigenetics epigenomics methylation model organisms pluripotency Ten-eleven translocation (TET) methylcytosine dioxygenases were first described when TET1 was identified as a fusion partner of the mixed lineage leukaemia gene ( MLL ) in acute...
Biochem Soc Trans (2018) 46 (5): 1083–1091.
Published: 21 September 2018
... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cell cycle cell differentiation phosphorylation/dephosphorylation transcription factors The miracle of embryo development sees a single fertilised egg generate millions of specialised...
Biochem Soc Trans (2008) 36 (3): 528–530.
Published: 21 May 2008
... Society 2008 cell differentiation cell proliferation mRNA translation Musashi protein neural stem cell Xenopus Musashi exerts translational repression of target mRNAs via a 5′-cap-dependent mechanism in neural stem cells, but paradoxically exerts target mRNA translational activation...
Biochem Soc Trans (2007) 35 (1): 133–135.
Published: 22 January 2007
...N. Prevarskaya; M. Flourakis; G. Bidaux; S. Thebault; R. Skryma A major clinical problem with PC (prostate cancer) is the cell's ability to survive and proliferate upon androgen withdrawal. Indeed, deregulated cell differentiation and proliferation, together with the suppression of apoptosis...
Biochem Soc Trans (2006) 34 (6): 1133–1137.
Published: 25 October 2006
... remain roughly constant as cells differentiate, despite large changes in the numbers of active polymerases and nucleoplasmic volumes. cell differentiation chromatin loop genome organization RNA polymerase transcription factory Molecules are concentrated within cells into distinct cellular...