... of differentiation-based approaches. Correspondence: Virginie Sottile ( virginie.sottile@unipv.it ) 14 6 2021 6 8 2021 10 8 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer cell cell differentiation stem cell therapy...

... with a host of haematopoietic neoplasms [ 4 ] as well as impaired immune system responses [ 5 ]. Figure 1. Haematopoiesis involves the epigenetic silencing of alternate fate genes, reducing multipotency and the self-renewal capacity as cells differentiate. Haematopoietic stem cells (HSC) differentiate...

... patterning cell differentiation homeobox genes human pluripotent stem cells neural crest cells Human pluripotent stem cells (hPSCs) have become a powerful resource to study embryonic development, circumventing both the technical and ethical obstacles associated with the use of human embryos...

... 5 6 2019 6 6 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cell differentiation developmental biology T cells A key attribute of T cell immunity is the expression of a distinct T cell receptor (TCR) on each T...

... of the Biochemical Society 2019 cell differentiation epigenetics epigenomics methylation model organisms pluripotency Ten-eleven translocation (TET) methylcytosine dioxygenases were first described when TET1 was identified as a fusion partner of the mixed lineage leukaemia gene ( MLL ) in acute...

... such as a switch in expression dynamics that accompany the transition to differentiation [ 29 ], or a change in proneural protein structure/activity via post-translational modification (see below). cell cycle cell differentiation phosphorylation/dephosphorylation transcription factors Embryogenesis...

... Society 2008 cell differentiation cell proliferation mRNA translation Musashi protein neural stem cell Xenopus Musashi exerts translational repression of target mRNAs via a 5′-cap-dependent mechanism in neural stem cells, but paradoxically exerts target mRNA translational activation...

...N. Prevarskaya; M. Flourakis; G. Bidaux; S. Thebault; R. Skryma A major clinical problem with PC (prostate cancer) is the cell's ability to survive and proliferate upon androgen withdrawal. Indeed, deregulated cell differentiation and proliferation, together with the suppression of apoptosis...

... remain roughly constant as cells differentiate, despite large changes in the numbers of active polymerases and nucleoplasmic volumes. cell differentiation chromatin loop genome organization RNA polymerase transcription factory Molecules are concentrated within cells into distinct cellular...