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Keywords: cell death
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Biochem Soc Trans (2022) 50 (4): 1119–1128.
Published: 28 July 2022
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . BCL-2 proteins cancer cell death chemotherapy The BCL-2 family proteins are key-regulators of the intrinsic apoptotic pathway. Members of this family contain BCL-2 homology (BH...
Biochem Soc Trans (2022) 50 (3): 1205–1213.
Published: 27 June 2022
... in cell survival and mammalian embryonic development. In recent years, GPX4 has been associated with a cell death modality dubbed ferroptosis. The framing of this molecular pathway of cell death was essential for understanding the conditions that determine GPX4 dependency and ultimately to the process...
Biochem Soc Trans (2022) 50 (2): 813–824.
Published: 28 March 2022
...Elias S. Weiler; Tamas G. Szabo; Irmina Garcia-Carpio; Andreas Villunger The death fold domain-containing protein PIDD1 has recently attracted renewed attention as a regulator of the orphan cell death-related protease, Caspase-2. Caspase-2 can activate p53 to promote cell cycle arrest in response...
Biochem Soc Trans (2020) 48 (5): 2253–2259.
Published: 14 October 2020
...Helene Nehring; Svenja Meierjohann; Jose Pedro Friedmann Angeli Lipid peroxidation has been associated with a wide array of (patho)physiological conditions. Remarkably, in the last few years, a novel cell death modality termed ferroptosis was recognized as a process initiated by iron-dependent...
Biochem Soc Trans (2020) 48 (3): 1213–1225.
Published: 08 June 2020
.... Correspondence: Myung-Shik Lee ( mslee0923@yuhs.ac ) 8 3 2020 15 5 2020 19 5 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cell death innate immunity Toll-like receptors Adaptive immunity plays an indispensable...
Biochem Soc Trans (2018) 46 (3): 609–617.
Published: 20 April 2018
... responses including cell death via necrosis, pyroptosis (involving inflammation) or apoptosis (which avoids inflammation). Flaviviruses exploit these mechanisms and subvert them to prolong viral replication. The different effects induced by DENV, WNV, JEV and ZIKV are reviewed. Host cell surface...
Biochem Soc Trans (2018) 46 (2): 351–360.
Published: 09 March 2018
... neurodegenerative disorders that include Alzheimer's disease, Huntington's disease, and Parkinson's disease. SIRT1 can control stem cell proliferation, block neuronal injury through limiting programmed cell death, drive vascular cell survival, and control clinical disorders that include dementia and retinopathy...
Biochem Soc Trans (2018) 46 (2): 207–215.
Published: 22 February 2018
... lysosomal contents, which include proteolytic enzymes of the cathepsin family. This, in turn, activates several intracellular cascades that promote a type of regulated cell death, called lysosome-dependent cell death (LDCD). LDCD can be inhibited by pharmacological or genetic blockade of cathepsin activity...
Biochem Soc Trans (2017) 45 (1): 163–172.
Published: 15 February 2017
... this mechanism also holds true for LRRK2 awaits further confirmation. The function of the GTPase domain and its contribution to the pathogenic actions of familial LRRK2 mutations in PD models remains incompletely characterized. cell death enzyme activity leucine-rich repeat kinase neurodegeneration...
Biochem Soc Trans (2016) 44 (1): 40–45.
Published: 09 February 2016
... into energy metabolism and mitochondrial calcium handling to activation of permeability transition pore (PTP) and cell death. PolyP is a gliotransmitter which transmits the signal in astrocytes via activation of P2Y1 receptors and stimulation of phospholipase C. PolyP-induced calcium signal in astrocytes can...
Biochem Soc Trans (2012) 40 (5): 1070–1073.
Published: 19 September 2012
... acute effects in a very reductionist system, one benefit is that it is relatively easy to assay large numbers of variants in a rapid manner. autophagy cell death inclusion body leucine-rich repeat kinase 2 (LRRK2) neurite Parkinson's disease The identification of dominant mutations...
Biochem Soc Trans (2011) 39 (5): 1493–1498.
Published: 21 September 2011
.... Plant infection assays showed that the fungus undergoes massive PCD (programmed cell death) during early stages of infection. Further studies showed that fungal virulence was fully correlated with the ability of the fungus to cope with plant-induced PCD. Together, our result show that BcBir1 is a major...
Biochem Soc Trans (2011) 39 (5): 1544–1548.
Published: 21 September 2011
... and cell death stimulus, respectively, aiming to understand by which means filamentous fungi are driven towards cell death. Here, we review some of our findings about FOH-induced cell death in A. nidulans . 1 Owing to exceptional unforeseen circumstances, this speaker was unable to give...
Biochem Soc Trans (2011) 39 (5): 1520–1526.
Published: 21 September 2011
...Ralf J. Braun; Benedikt Westermann Mitochondria play crucial roles in programmed cell death and aging. Different stimuli activate distinct mitochondrion-dependent cell death pathways, and aging is associated with a progressive increase in mitochondrial damage, culminating in oxidative stress...
Biochem Soc Trans (2007) 35 (5): 1119–1121.
Published: 25 October 2007
... email gcb@mole.bio.cam.ac.uk 8 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cell death inflammation nitric oxide peroxynitrite reactive nitrogen species reactive oxygen species Inflammatory neurodegeneration is neurodegeneration caused...
Biochem Soc Trans (2006) 34 (5): 953–956.
Published: 25 October 2006
.... Cu,Zn-SOD and Mn-SOD cause fairly rapid NO breakdown to peroxynitrite in the presence of H 2 O 2 , and this does contribute to NO consumption and cell death in cells treated with NO and H 2 O 2 [ 21 ]. ROS (reactive oxygen species) are a group of chemically reactive molecules derived from...
Biochem Soc Trans (2004) 32 (3): 493–495.
Published: 01 June 2004
...M. Degli Esposti The role of mitochondria in cell death has been increasingly appreciated in the last few years and is now well established in a variety of cellular systems. At present we know that the involvement of mitochondria is regulated by proteins of the Bcl-2 (B-cell lymphocytic-leukaemia...
Biochem Soc Trans (2001) 29 (6): 696–702.
Published: 01 November 2001
... earlier in the cascade. Many cellular stresses provoke apoptosis by damaging mitochondria which results in the release of factors [such as cytochrome c and SMAC (second mitochondrial-derived activator of caspase)/Diablo] that trigger caspase activation and cell death. Here, we discuss the hierarchical...
Biochem Soc Trans (2001) 29 (6): 684–688.
Published: 01 November 2001
... or apoptotic cell death. Cell death induced through the p53 pathway is executed by the caspase proteinases, which, by cleaving their substrates, lead to the characteristic apoptotic phenotype. Caspase activation by p53 occurs through the release of apoptogenic factors from the mitochondria, including...
Biochem Soc Trans (2000) 28 (4): 452–455.
Published: 01 August 2000
...D. E. Brenneman; C. Y. Spong; I. Gozes In studying the mediators of VIP neurotrophism in the central nervous system, two glial proteins have been discovered. Both of these proteins contain short peptides that exhibit femtomolar potency in preventing neuronal cell death from a wide variety...