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Keywords: cell cycle
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221400.
Published: 04 May 2023
..., the diverse modes of proteolytic inhibition by securin and the CDK1–cyclin B1–Cks1 (CCC) complex, regulation of the protease activity by vertebrate-specific binding partners, and the implications of the latest discoveries for ordered cell cycle progression. Structural studies of the separase protease...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1105–1118.
Published: 30 August 2022
...Anastasia Audrey; Lauren de Haan; Marcel A.T.M. van Vugt; H. Rudolf de Boer Failure of cells to process toxic double-strand breaks (DSBs) constitutes a major intrinsic source of genome instability, a hallmark of cancer. In contrast with interphase of the cell cycle, canonical repair pathways...
Articles
CDK activity sensors: genetically encoded ratiometric biosensors for live analysis of the cell cycle
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1081–1090.
Published: 08 June 2022
...Michael A. Q. Martinez; David Q. Matus Cyclin-dependent kinase (CDK) sensors have facilitated investigations of the cell cycle in living cells. These genetically encoded fluorescent biosensors change their subcellular location upon activation of CDKs. Activation is primarily regulated...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 813–824.
Published: 28 March 2022
...Elias S. Weiler; Tamas G. Szabo; Irmina Garcia-Carpio; Andreas Villunger The death fold domain-containing protein PIDD1 has recently attracted renewed attention as a regulator of the orphan cell death-related protease, Caspase-2. Caspase-2 can activate p53 to promote cell cycle arrest in response...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2133–2141.
Published: 21 September 2021
...Liu Mei; Jeanette Gowen Cook The cell division cycle must be strictly regulated during both development and adult maintenance, and efficient and well-controlled DNA replication is a key event in the cell cycle. DNA replication origins are prepared in G1 phase of the cell cycle in a process known...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 829–841.
Published: 12 April 2021
...Ciaran G. Morrison The maintenance of genome stability involves integrated biochemical activities that detect DNA damage or incomplete replication, delay the cell cycle, and direct DNA repair activities on the affected chromatin. These processes, collectively termed the DNA damage response (DDR...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 245–256.
Published: 03 February 2020
... on behalf of the Biochemical Society 2020 cell cycle Golgi apparatus mitosis The Golgi complex (GC) has a central role in the transport, processing, and targeting of lipids and proteins to their final destinations [ 1 ]. The basic transport function does not require a specific structural...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1083–1091.
Published: 21 September 2018
...Laura J.A. Hardwick; Roberta Azzarelli; Anna Philpott Embryogenesis requires an exquisite regulation of cell proliferation, cell cycle withdrawal and differentiation into a massively diverse range of cells at the correct time and place. Stem cells also remain to varying extents in different adult...
Articles
In Collection
Embryonic development
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 797–806.
Published: 22 June 2018
... under the Creative Commons Attribution License 4.0 (CC BY) . cell cycle female gametes meiosis In mammals, under hormonal cues, oocytes mature into eggs that are then fertilized [ 1 – 3 ]. Oocytes spend the vast majority of their life having entered meiosis but arresting before its...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (5): 1125–1136.
Published: 12 September 2017
.... As potentially druggable enzymes, disease-associated DUBs are of increasing interest as pharmaceutical targets. The biology, structure and regulation of DUBs have been extensively reviewed elsewhere, so here we focus specifically on roles of DUBs in regulating cell cycle processes in mammalian cells. Over...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (2): 313–322.
Published: 13 April 2017
...Ee Phie Tan; Francesca E. Duncan; Chad Slawson Cell division (mitosis) and gamete production (meiosis) are fundamental requirements for normal organismal development. The mammalian cell cycle is tightly regulated by different checkpoints ensuring complete and precise chromosomal segregation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1281–1288.
Published: 19 October 2016
... of the Biochemical Society 2016 Correspondence: Andrew M. Fry ( amf5@le.ac.uk ) 23 5 2016 14 6 2016 15 6 2016 cell cycle EMAP EML MAP microtubule oncogenic fusion Mammals express six EML proteins that have been reported under different names, but we refer to here as EML1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1534–1537.
Published: 17 November 2014
...Nicola Brownlow; Tanya Pike; Victoria Crossland; Jeroen Claus; Peter Parker Cytokinesis is the final act of the cell cycle where the replicated DNA and cellular contents are finally split into two daughter cells. This process is very tightly controlled as DNA segregation errors and cytokinesis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1471–1476.
Published: 18 September 2014
...Alessandro Poli; Sara Mongiorgi; Lucio Cocco; Matilde Y. Follo Protein kinases C (PKCs) are a family of serine/threonine kinases which act as key regulators in cell cycle progression and differentiation. Studies of the involvement of PKCs in cell proliferation showed that their role is dependent...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1219–1223.
Published: 11 August 2014
... transplantation, or drug toxicity, has a high morbidity and mortality rate and presents a significant burden to health services worldwide. AKI primarily affects the renal cortex, in particular PTCs (proximal tubular epithelial cells). Current research demonstrates causality between G 2 /M cell cycle arrest...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 76–81.
Published: 23 January 2014
... that an important component of NF-κB's function includes regulation of the cell cycle. However, this aspect of its behaviour is often overlooked and receives less attention than its ability to induce inflammatory gene expression. In the present article, we provide an updated review of the current state of our...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1687–1691.
Published: 20 November 2013
... beata.grallert@rr-research.no ). 3 9 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cancer cell cycle eukaryotic initiation factor 2α (eIF2α) phosphorylation Gcn2 translational regulation Gcn2 was first described in budding yeast as a serine/threonine...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1720–1725.
Published: 20 November 2013
... Society 2013 cell cycle development DNA replication origin of replication replication stress S-phase Genome duplication is an essential biological process that is tightly regulated and intricately co-ordinated with other cellular functions, including transcription, proliferation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 1008–1016.
Published: 18 July 2013
... ). 3 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cell cycle cyclin cyclin-dependent kinase (CDK) phosphorylation transcription X-ray crystallography It was Louise Johnson who first drew an analogy between protein kinase families and human families...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 777–782.
Published: 23 May 2013
... in the DNA-damage response and in cell cycle progression through S-phase and into G 2 . Furthermore, as part of NuRD, it participates in regulating acetylation levels of p53, thereby indirectly regulating the G 1 /S cell cycle checkpoint. Although CHD4 has a somewhat complicated relationship with the cell...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 880–885.
Published: 20 July 2012
...Alexander M.J. Rattray; Berndt Müller Histone proteins are essential for the packaging of DNA into chromosomes. Histone gene expression is cell-cycle-regulated and coupled to DNA replication. Control of histone gene expression occurs at the transcriptional and post-transcriptional level and ensures...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 778–783.
Published: 20 July 2012
... rapid destruction of mRNAs carrying a PTC (premature translation termination codon). However, some studies have indicated that in human cells UPF1 has additional roles, possibly unrelated to NMD, which are carried out in the nucleus. These might involve telomere maintenance, cell cycle progression...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1742–1746.
Published: 21 November 2011
... and for the cytoskeleton on its cytoplasmic surface. Both sets of anchors are proteins called NETs (nuclear envelope transmembrane proteins), embedded respectively in the inner or outer nuclear membranes. Several lines of evidence indicate that the nuclear envelope contributes to cell-cycle regulation. These contributions...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 600–605.
Published: 22 March 2011
... employment differs between these two phases of the cell cycle. The Ddc1 (human Rad9) subunit of the clamp directly activates Mec1 in G 1 -phase, an activity identified only in S. cerevisiae so far. However, in G 2 -phase, the 9-1-1 clamp activates the checkpoint by two mechanisms. One mechanism includes...
Articles
Melanie J. Welham, Emmajayne Kingham, Yolanda Sanchez-Ripoll, Benjamin Kumpfmueller, Michael Storm, Heather Bone
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 674–678.
Published: 22 March 2011
... Journal compilation © 2011 Biochemical Society 2011 cell cycle embryonic stem cell glycogen synthase kinase 3 (GSK-3) phosphoinositide 3-kinase (PI3K) pluripotency proliferation self-renewal Given the fact that PI3Ks have been implicated in regulation of both ESC proliferation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1242–1246.
Published: 24 September 2010
...Béla Novák; P.K. Vinod; Paula Freire; Orsolya Kapuy Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)–CycB (cyclin B) activity. In the present review, we illustrate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 577–582.
Published: 22 March 2010
... determination, cell-cycle progression and gene regulation. The present mini-review encompasses key advances in our understanding of the molecular mechanisms controlling male gametophyte patterning in angiosperms. A brief overview of male gametophyte development is presented, followed by a discussion...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (1): 78–82.
Published: 19 January 2010
... and dephosphorylation of its destruction box [ 25 ]. Degradation of different APC/C Cdh1 substrates takes place at different stages of the cell cycle. We have recently observed that much of this timing is determined by sequential dephosphorylation of protective phosphorylation of destruction boxes both in mammalian...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (1): 1–5.
Published: 19 January 2010
... degradation. The UPS represents a major mechanism of cell-cycle regulation which ensures the correct and unidirectional progression of the cell cycle. Degradation of the vast majority of cell-cycle regulators is controlled by two classes of E3 ubiquitin ligase complexes: the SCF (Skp1/cullin/F-box...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (5): 931–935.
Published: 21 September 2009
... as a function of the cell cycle. The activating role of miRNAs is now being confirmed in the immature Xenopus oocyte, which mimics the quiescent state. Argonaute 2 (AGO2) cell cycle Fragile X mental retardation-related protein 1 (FXR1) microribonucleoprotein (miRNP) quiescence translational activation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 926–930.
Published: 22 July 2009
... fragments, which are matured into a continuous new strand by the actions of RNAse H, Fen1 (flap endonuclease 1), Dna1, Pol δ and DNA ligase 1 [ 2 , 8 , 9 ]. Eukaryotic DNA replication occurs during S-phase of the cell cycle and is a highly regulated process involving various replication proteins [ 2 – 9...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (3): 483–494.
Published: 20 May 2009
... laboratory's recent work, which has revealed that the way cells respond to DSBs is modulated in a cell-cycle-dependent manner to ensure that the cell uses the DSB repair system that is most suited to its cell-cycle stage. Finally, I explain how our increasing knowledge of the DDR is suggesting new avenues...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 864–867.
Published: 19 September 2008
...Marc Piechaczyk; Rosa Farràs JunB is a member of the AP-1 (activator protein-1) family of dimeric transcription factors. It exerts a dual action on the cell cycle. It is best known as a cell proliferation inhibitor, a senescence inducer and a tumour suppressor. As for the molecular mechanisms...
Articles
Prabhakar Rajan, Luke Gaughan, Caroline Dalgliesh, Amira El-Sherif, Craig N. Robson, Hing Y. Leung, David J. Elliott
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 505–507.
Published: 21 May 2008
... in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 411–415.
Published: 21 May 2008
...Andrea Krapp; Viesturs Simanis The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe . Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1342–1346.
Published: 25 October 2007
...M.M. Murray; P.B. Mullan; D.P. Harkin BRCA1 (breast-cancer susceptibility gene 1) is a tumour suppressor, implicated in the hereditary predisposition to breast and ovarian cancer. BRCA1 has been implicated in a number of cellular processes including DNA repair and recombination, cell cycle...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 222–224.
Published: 20 March 2007
.... Pelloquin L. Baldin V. Oustrin M.L. Ducommun B. Prog. Cell Cycle Res. 1995 1 207 214 16 Hirota T. Morisaki T. Nishiyama Y. Marumoto T. Tada K. Hara T. Masuko N. Inagaki M. Hatakeyama K. Saya H. J. Cell Biol. 2000 149 1073 1086...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 405–409.
Published: 20 March 2007
... in DENSPM-treated cells in relation to effects on cell cycle kinetics and induction of apoptosis. To really understand the role of polyamines in cell cycle regulation and apoptosis, we believe it is now time to go through the vast polyamine literature in a meta-analysis-based manner. This short review does...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 391–395.
Published: 20 March 2007
... of the cell cycle. We investigated the effect of quinidine and caesium (Cs + ) on cell proliferation, LDH (lactate dehydrogenase) release, free internal calcium, membrane potential, polyamine concentration, ODC (ornithine decarboxylase) activity and polyamine uptake in C6 glioma cells. The EC 50 for reducing...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 649–651.
Published: 01 August 2005
..., leading to an increase in RhoE levels. In addition, phosphorylation reduces its association with membranes and correlates with its ability to induce loss of stress fibres. RhoE also acts independently of ROCK to inhibit cell cycle progression, in part by preventing translation of cyclin D 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 724–727.
Published: 01 August 2005
... apoptosis carbonic anhydrase cell cycle coxib cytochrome c NAG-1 (non-steroidal anti-inflammatory drug-activated gene) The initial response of many investigators, including ourselves, to the epidemiological data showing that NSAIDs are associated with a decreased incidence of cancer...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (3): 471–473.
Published: 01 June 2005
...-ordinately regulated and mutually dependent on each other [ 1 ]. The cell-cycle regulation of histone protein production is achieved by regulating the steady-state levels of histone mRNA. Metazoan histone mRNAs are the only eukaryotic mRNAs that do not end in a polyadenylated tail, but end...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 294–296.
Published: 01 February 2005
... physiological relevance, since it allows us to coordinate cell growth with cell cycle progression and it is responsible for cell size homeostasis. The cell sizer mechanism requires the overcoming of two sequential thresholds, involving Cln3 and Far1, and Clb5,6 and Sic1, respectively. When both thresholds...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 724–727.
Published: 26 October 2004
...L.A. Passmore The APC (anaphase-promoting complex) is a multisubunit E3 ubiquitin ligase that targets cell-cycle-related proteins for degradation by the 26 S proteasome. The APC contains at least 13 subunits and is regulated by the binding of co-activator proteins and by phosphorylation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 982–984.
Published: 26 October 2004
... that the proliferation of B-cells was inhibited by retinoids, and that this was due to rapid inhibition of the cell cycle machinery regulating G 1 -to-S transition. In contrast, the proliferation of T-cells was enhanced by physiological levels of retinoic acid, and the effect was due to induction of IL-2 (interleukin 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 967–972.
Published: 26 October 2004
.... The basic paradigm emerging is that a number of groups of genes are expressed in successive waves at different cell cycle times. Transcription of a particular group is controlled by a common DNA motif present in each gene's promoter, bound by a transcription factor complex. Each motif and transcription...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (2): 360–361.
Published: 01 April 2004
...L. Martínez-Gac; B. Álvarez; Z. García; M. Marqués; M. Arrizabalaga; A.C. Carrera Cell cycle progression is a tightly controlled process. To initiate cell division, mitogens trigger a number of early signals that promote the G 0 –G 1 transition by inducing cell growth and the activation of G 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (2): 236–239.
Published: 01 April 2004
... September 2003 © 2004 Biochemical Society 2004 Archaea Cdc6 cell cycle DNA replication mini-chromosome maintenance (MCM) origin recognition complex (ORC) Abbreviations used: ORC, origin recognition complex; MCM, mini-chromosome maintenance. 236 Biochemical Society...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1526–1529.
Published: 01 December 2003
... model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression. 1 To whom correspondence should be addressed...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 907–911.
Published: 01 October 2003
... consist of two series of transients; the first lasts about 4 h, from metaphase II until interphase of the first cell cycle, and the second lasts the duration of the first mitotic division. This cell-cycle-regulated aspect to the pattern of Ca 2+ signalling at fertilization is reflected in the role...
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