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Keywords: caspases
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Articles
Biochem Soc Trans (2024) BST20230962.
Published: 09 February 2024
... Csx30. This model is adopted from the classical biochemistry described for cysteine proteases. ( B ) Alternatively, similar to human legumain and caspases, deprotonation of the cysteine could occur directly by the substrate, followed by the nucleophilic attack. Figure 4. The big insertion...
Articles
Biochem Soc Trans (2022) 50 (2): 813–824.
Published: 28 March 2022
...Elias S. Weiler; Tamas G. Szabo; Irmina Garcia-Carpio; Andreas Villunger The death fold domain-containing protein PIDD1 has recently attracted renewed attention as a regulator of the orphan cell death-related protease, Caspase-2. Caspase-2 can activate p53 to promote cell cycle arrest in response...
Articles
Biochem Soc Trans (2015) 43 (3): 502–507.
Published: 01 June 2015
..., including mechanical stimulation, oxygen-glucose deprivation, a rise of [Ca 2+ ] i , caspase cleavage and phosphorylation. Within this review, the regulation of Panx1 channels is discussed, with a focus on how they may contribute to platelet function. In addition to Panx1-mediated ATP release from...
Articles
Biochem Soc Trans (2015) 43 (2): 229–234.
Published: 07 April 2015
...Dale D.O. Martin; Michael R. Hayden In a little more than a decade, post-translational myristoylation (PTMyr) has become an established post-translational modification during cell death. It involves the addition of the fatty acid myristate to newly exposed N-terminal glycines following caspase...
Articles
Biochem Soc Trans (2001) 29 (6): 704–706.
Published: 01 November 2001
..., Jip-1, prevents JNK activity and significantly reduces the extent of apoptosis induced by PBOX-6. This demonstrates the requirement for JNK in the cellular response to this apoptotic agent. In addition, PBOX-6 activates caspase-3-like proteases in K562 and HL-60 cells. The caspase-3 inhibitor, Z-Asp...
Articles
Biochem Soc Trans (2001) 29 (6): 684–688.
Published: 01 November 2001
... or apoptotic cell death. Cell death induced through the p53 pathway is executed by the caspase proteinases, which, by cleaving their substrates, lead to the characteristic apoptotic phenotype. Caspase activation by p53 occurs through the release of apoptogenic factors from the mitochondria, including...