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Keywords: cartilage degradation
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Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocytes

S. J. Gilbert, V. C. Duance, D. J. Mason
Journal: Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (6): 886–889.
https://doi.org/10.1042/bst0300886
Published: 01 November 2002
... of the protein kinase, PKR. PACT and PKR are upstream components of a number of signal transduction and gene transcription pathways used by pro-inflammatory cytokines. We have investigated the role of PACT and PKR in articular cartilage degradation using cytokine treatment of bovine primary chondrocytes...
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