... also been shown to drive pathological mechanisms in many common diseases. Osteoarthritis is a degenerative joint disorder, characterised by the progressive destruction of articular cartilage. This breakdown of the cartilage is driven by the metalloproteinases, and it has long been established...

...Bethanie I. Ayerst; Anthony J. Day; Victor Nurcombe; Simon M. Cool; Catherine L.R. Merry Most research strategies for cartilage tissue engineering use extended culture with complex media loaded with costly GFs (growth factors) to drive tissue assembly and yet they result in the production...

...Simon R. Tew; Peter D. Clegg The control of gene expression in articular chondrocytes is an essential factor in maintaining the homoeostasis of extracellular matrix synthesis and turnover necessary in healthy articular cartilage. Although much is known of how steady-state levels of gene expression...

...M. Plainfossé; P.V. Hatton; A. Crawford; Z.M. Jin; J. Fisher Low-friction surfaces are critical for efficient joint articulation. The tribological properties of articular cartilage have been studied extensively in native tissue and joints. Despite their importance, very few studies have examined...

...), cartilage, collagen type IV. Abbreviations used: BMP, bone morphogenetic protein; TGF, transforming growth factor; GDF. growth/differentiation factor; CDMP, cartilage-derived morphogenetic protein. 'e-mail ahreddi@ucdavis.edu 345 interpretation and differentiation of the pattern. Morphogenesis is induced...