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Keywords: cardiovascular disease
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Articles
Biochem Soc Trans (2021) 49 (5): 2189–2198.
Published: 19 October 2021
...Marina Diotallevi; Faseeha Ayaz; Thomas Nicol; Mark J. Crabtree Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide. In recent years, metabolism has...
Articles
Biochem Soc Trans (2021) 49 (5): 2101–2111.
Published: 08 September 2021
... agreement with JISC. cardiovascular disease cell plasticity lineage tracing single cell RNA sequencing vascular smooth muscle Vascular smooth muscle cells (VSMCs) reside in the medial layer of major blood vessels in mammals. They are generally quiescent in healthy, adult vessels, where...
Articles
Biochem Soc Trans (2021) 49 (1): 353–363.
Published: 22 February 2021
... of the Biochemical Society 2021 cardiovascular disease microrna phenotype vascular smooth muscle MicroRNAs (miRs) are short, non-coding RNAs that can act as master regulators of cellular function, switching entire pathways on or off through imperfect binding to the 3′ UTR of target mRNAs...
Articles
Biochem Soc Trans (2019) 47 (5): 1259–1268.
Published: 18 October 2019
... a mechanistic view of ABCG5/G8-mediated sterol transport. Correspondence: Jyh-Yeuan Lee ( jyh-yeuan.lee@uottawa.ca ) 18 7 2019 26 9 2019 30 9 2019 ATP-binding cassette transporters cardiovascular disease cholesterol transport lipid metabolism sitosterolemia structural biology...
Articles
Articles
Biochem Soc Trans (2015) 43 (5): 1079–1084.
Published: 09 October 2015
... TRIB1 locus as being significantly associated with multiple plasma lipid traits and cardiovascular disease (CVD) in humans. The involvement of TRIB1 in hepatic lipid metabolism has been validated through viral-mediated hepatic overexpression of the gene in mice; increasing levels of TRIB1 decreased...
Articles
Biochem Soc Trans (2015) 43 (5): 1108–1111.
Published: 09 October 2015
...Sabrina Prudente; Vincenzo Trischitta Insulin resistance is pathogenic for many prevalent disorders including type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), polycystic ovary syndrome, non-alcoholic fatty liver disease, Alzheimer's and Parkinson's diseases and several cancers...
Articles
Biochem Soc Trans (2014) 42 (4): 996–1000.
Published: 11 August 2014
... in vascular homoeostasis, focusing our attention on the importance of the NO pathway alterations in cardiovascular diseases and their relationship to major risk factors. 1 To whom correspondence should be addressed (email viviana.cavalca@unimi.it ). 1 5 2014 © The Authors Journal...
Articles
Biochem Soc Trans (2014) 42 (4): 928–933.
Published: 11 August 2014
... with cardiovascular disease, the specific effect of hyper- (or hypo-) glycaemia is less well understood. The present review focuses on the impact that glycaemic dysregulation has on respiratory function and ROS (reactive oxygen species) generation in the endothelial cells that are critical in preventing several key...
Articles
Biochem Soc Trans (2014) 42 (2): 523–527.
Published: 20 March 2014
...Branka Vulesevic; Ross W. Milne; Erik J. Suuronen Diabetes is a well-known risk factor for the development of cardiovascular diseases. Diabetes affects cardiac tissue through several different, yet interconnected, pathways. Damage to endothelial cells from direct exposure to high blood glucose...
Articles
Biochem Soc Trans (2014) 42 (2): 231–238.
Published: 20 March 2014
...; it is also a potent survival factor and an upstream regulator of mitochondrial biogenesis. In diabetes and cardiovascular disease, CREB protein content is decreased in the vascular media, and its regulation in aberrant in β-cells, neurons and cardiomyocytes. Loss of CREB content and function leads...
Articles
Biochem Soc Trans (2014) 42 (2): 528–533.
Published: 20 March 2014
... endothelial cell dysfunction is one of the basic features and early indicators of cardiovascular diseases [ 9 ]. During normal vascular homoeostasis, the healthy endothelium responds to a number of physical and chemical signals, thereby regulating vascular tone, adhesion of circulating cells and smooth muscle...
Articles
Biochem Soc Trans (2012) 40 (1): 1–5.
Published: 19 January 2012
... ‘protective’ mechanisms of cAMP action will inform the development of the next generation of pharmaceuticals specifically designed to combat endothelial inflammation associated with cardiovascular disease. Together, these findings reveal a central co-ordinated role for Epac1 and the ERK MAPK cascade...
Articles
Biochem Soc Trans (2007) 35 (3): 484–486.
Published: 22 May 2007
... of these factors contribute to increased risk of CVD (cardiovascular disease). Since little is known about postprandial dyslipidaemia in overweight children, we sought to compare fasting levels of apoB48 with the HOMA-IR (homoeostasis model assessment of insulin resistance) score, classic lipid profile and VAT...
Articles
Biochem Soc Trans (2006) 34 (5): 903–909.
Published: 25 October 2006
...J. Striessnig; A. Koschak; M.J. Sinnegger-Brauns; A. Hetzenauer; N.K. Nguyen; P. Busquet; G. Pelster; N. Singewald Voltage-gated LTCCs (L-type Ca 2+ channels) are established drug targets for the treatment of cardiovascular diseases. LTCCs are also expressed outside the cardiovascular system...
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Biochem Soc Trans (2004) 32 (6): 1051–1056.
Published: 26 October 2004
... dreamt of a decade ago. 1 email jshepherd@gri-biochem.org.uk 17 6 2004 © 2004 The Biochemical Society 2004 cardiovascular disease cholesterol absorption cholesterol synthesis ezetimibe HMG CoA reductase inhibitors (statins) lipids Among the plethora of risk...
Articles
Biochem Soc Trans (2003) 31 (5): 1085–1089.
Published: 01 October 2003
... the potential to accelerate cholesterol deposition in the plaque and to cause plaque disruption, explaining in part the increased cardiovascular disease found in diabetes. 1 e-mail daowens@tcd.ie Triglyceride-Rich Lipoproteins and Atherosclerosis a meeting of the Biochemical Society's Irish Area...