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Keywords: cardioprotection
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Articles
Biochem Soc Trans (2018) 46 (5): 1119–1127.
Published: 21 September 2018
... short-term energy buffer and transport system in the cardiomyocyte. Proof-of-principle data from several transgenic mouse models have demonstrated robust cardioprotection by either raising myocardial creatine levels or by overexpressing specific CK isoforms. The effect on cardiac function, high-energy...
Articles
Biochem Soc Trans (2014) 42 (2): 270–273.
Published: 20 March 2014
... of the importance of HSP20 in contractile function and cardioprotection has been gained over the last decade. The present mini-review highlights more recent findings illustrating the cardioprotective properties of HSP20 and its potential as a therapeutic agent. T.P.M., S.C. and G.S.B. are funded by Heart...
Articles
Biochem Soc Trans (2012) 40 (1): 210–214.
Published: 19 January 2012
... increases in cAMP, Hsp20 is phosphorylated on Ser 16 by PKA (protein kinase A). This covalent modification is required for many of its cardioprotective effects. Both Hsp20 expression levels and its phosphorylation on Ser 16 are increased in ischaemic myocardium. Transgenic mouse models with cardiac-specific...
Articles
Biochem Soc Trans (2010) 38 (4): 841–860.
Published: 26 July 2010
...), the adenine nucleotide translocase and the phosphate carrier are summarized and other potential interactions with outer mitochondrial membrane proteins are discussed. I then review the evidence that MPTP opening mediates cardiac reperfusion injury and that MPTP inhibition is cardioprotective. Inhibition may...
Articles
Biochem Soc Trans (2007) 35 (5): 1052–1054.
Published: 25 October 2007
... death pathways induced by cardiac ischaemia/reperfusion injury. PKC (protein kinase C) ϵ plays a critical role in cardioprotective signalling pathways that protect the heart from ischaemia/reperfusion. Emerging evidence suggests that the cardioprotective target of PKCϵ resides at the mitochondria...