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Keywords: cardiac arrhythmia
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Articles
Biochem Soc Trans (2022) 50 (6): 1737–1751.
Published: 16 November 2022
... of the late sodium current (INaL), which impairs the action potential waveform and can cause severe cardiac arrhythmias. Moreover, long-term, low-dose exposure to PY displays oxidative stress in the heart, which could induce tissue remodeling and impairment. Isolated and preliminary evidence supports...
Articles
Biochem Soc Trans (2021) 49 (5): 1941–1961.
Published: 13 October 2021
...+ cardiac arrhythmia cardiomyocytes skeletal myocytes sodium channels Transmembrane action potential initiation and propagation, mediated by surface membrane Na + channel (Nav) proteins, is strategic to activation in excitable cells, of which skeletal and cardiac myocytes constitute important...
Articles
Biochem Soc Trans (2019) 47 (6): 1749–1756.
Published: 26 November 2019
... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 A kinase anchoring protein adenylate cyclase cAMP cardiac arrhythmia cardiomyocytes molecular scaffolds Adenylyl cyclases (ACs) generate cAMP from ATP in response to hormone stimulation...
Articles
Biochem Soc Trans (2019) 47 (5): 1393–1404.
Published: 24 September 2019
... focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations...
Articles
Biochem Soc Trans (2015) 43 (3): 410–416.
Published: 01 June 2015
...Katja Rietdorf; Said Masoud; Fraser McDonald; Michael J. Sanderson; Martin D. Bootman Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia. Substantial evidence indicates that cardiomyocytes located in the pulmonary veins [pulmonary vein sleeve cells (PVCs)] cause AF...
Articles
Biochem Soc Trans (2014) 42 (2): 295–301.
Published: 20 March 2014
... medium, provided the original work is properly cited. cAMP cardiac arrhythmia caveolin 3 evolution Popeye-domain-containing protein (Popdc) TREK-1 The Popdc (Popeye-domain-containing) gene family has been discovered independently by two groups that aimed at identifying novel genes...
Articles
Biochem Soc Trans (2007) 35 (5): 952–956.
Published: 25 October 2007
...M.G. Chelu; X.H.T. Wehrens Ventricular arrhythmias deteriorating into sudden cardiac death are a major cause of mortality worldwide. The recent linkage of a genetic form of cardiac arrhythmia to mutations in the gene encoding RyR2 (ryanodine receptor 2) has uncovered an important role of this SR...