... and antimicrobial. We ask: is this definition of a gasotransmitter appropriate in the cases of nitric oxide, carbon monoxide and hydrogen sulfide (H 2 S) in microbes? Recent advances show that, not only do bacteria synthesise each of these gases, but the molecules also have important signalling or messenger roles...

.... The focus is on two enzymes that make and utilize CO, CODH (carbon monoxide dehydrogenase) and ACS (acetyl-CoA synthase). In this pathway, CODH converts CO 2 into CO and ACS generates acetyl-CoA in a reaction involving Ni·CO, methyl-Ni and acetyl-Ni as catalytic intermediates. A 70 Å (1 Å=0.1 nm) channel...

..., and its metabolite, CO (carbon monoxide), exert protective effects in several organs against oxidative stimuli. In a landmark publication, we showed that the HO-1 pathway inhibits sFlt-1 and sEng in cultured cells and human placental tissue explants. Both CO and NO (nitric oxide) promote vascular...

... kinetics. 1 To whom correspondence should be addressed (email prr@ucl.ac.uk ). 13 8 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 carbon monoxide Fourier-transform infrared spectroscopy (FTIR spectroscopy) horseradish peroxidase rapid-scan time...

...L. Li; P.K. Moore Biologically active gases that occur naturally in the body include nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H 2 S). Each of these molecules is synthesized by enzymes which have been characterized biochemically and pharmacologically, and each acts, via well...