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Keywords: cancer genome
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Biochem Soc Trans (2022) 50 (6): 1911–1920.
Published: 10 November 2022
... division and genes encoded on them are transmitted in a non-mendelian manner. ecDNA can integrate into and exit from chromosomal DNA. The numbers of specific ecDNAs can change in response to treatment. This dynamic ability to remodel the cancer genome challenges long-standing fundamentals, providing new...