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Articles

The molecular mechanisms of human separase regulation

Jun Yu, David O. Morgan, Andreas Boland

Biochem Soc Trans (2023) BST20221400.

DOI: https://doi.org/10.1042/BST20221400

Published: 04 May 2023

... for this article was enabled by the participation of the University of Geneva in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with Individual. cancer cell cycle cryo-electron microscopy enzyme–substrate interactions...

View article titled, The molecular mechanisms of human separase regulation

Articles

Extracellular vesicles in carcinoma microenvironment

Larissa Tinô de Carvalho-Silva, Ana Gabriela C. Normando, Jamile de Oliveira Sá, Erison Santana dos Santos, Tatiane De Rossi, Ariane Fidelis Busso-Lopes, Ana Karina de Oliveira, Adriana F. Paes Leme

Biochem Soc Trans (2023) 51 (2): 771–781.

DOI: https://doi.org/10.1042/BST20221175

Published: 06 April 2023

...Larissa Tinô de Carvalho-Silva; Ana Gabriela C. Normando; Jamile de Oliveira Sá; Erison Santana dos Santos; Tatiane De Rossi; Ariane Fidelis Busso-Lopes; Ana Karina de Oliveira; Adriana F. Paes Leme Cancer is a significant cause of death, precluding increasing life expectancy worldwide...

View article titled, Extracellular vesicles in carcinoma microenvironment

Articles

Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

Jennifer Currenti, Archita Mishra, Michael Wallace, Jacob George, Ankur Sharma

Biochem Soc Trans (2023) 51 (2): 597–612.

DOI: https://doi.org/10.1042/BST20220157

Published: 20 March 2023

... response in HCC and might also have validity for predicting responses to immunotherapy in other cancers. In this review, we explore the immunosuppressive mechanisms and interactions of oncofetal cells in the TME of HCC and their potential implications for immunotherapy response. Correspondence: Ankur...

View article titled, Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

Articles

Eliminating oncogenic RAS: back to the future at the drawing board

Candy Laura Steffen, Pelin Kaya, Elisabeth Schaffner-Reckinger, Daniel Abankwa

Biochem Soc Trans (2023) 51 (1): 447–456.

DOI: https://doi.org/10.1042/BST20221343

Published: 23 January 2023

... that novel creative ideas continue to be important to exterminate RAS in cancer and other RAS pathway-driven diseases, such as RASopathies. Therefore, high affinity macromolecular binders raised against the effector lobe can potently inhibit RAS signalling. In addition to classical antibodies (∼150 kDa...

View article titled, Eliminating oncogenic RAS: back to the future at the drawing board

Includes: Supplementary data

Articles

Therapeutic targeting of TRAIL death receptors

In Collection

Cell death and survival

Francesca Di Cristofano, Andrew George, Vida Tajiknia, Maryam Ghandali, Laura Wu, Yiqun Zhang, Praveen Srinivasan, Jillian Strandberg, Marina Hahn, Ashley Sanchez Sevilla Uruchurtu, Attila A. Seyhan, Benedito A. Carneiro, Lanlan Zhou, Kelsey E. Huntington, Wafik S. El-Deiry

Biochem Soc Trans (2023) 51 (1): 57–70.

DOI: https://doi.org/10.1042/BST20220098

Published: 11 January 2023

... in patients with advanced cancer, dulanermin was shown to have a tolerable safety profile; however, its observed anticancer activity was limited [ 22 ]. Of note, the mean terminal phase half-life ( t 1/2 ) of rhTRAIL ranges from 0.56 to 1.02 h, likely restricting its ability to reach tumor cells [ 22 , 23...

View article titled, Therapeutic targeting of TRAIL death receptors

Articles

The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer

Aristeidis Panagiotis Sfakianos, Rebecca Mallory Raven, Anne Elizabeth Willis

Biochem Soc Trans (2022) 50 (6): 1885–1895.

DOI: https://doi.org/10.1042/BST20221035

Published: 13 December 2022

...Aristeidis Panagiotis Sfakianos; Rebecca Mallory Raven; Anne Elizabeth Willis Protein synthesis is dysregulated in the majority of cancers and this process therefore provides a good therapeutic target. Many novel anti-cancer agents are directed to target the initiation stage of translation, however...

View article titled, The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer

Articles

Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments

Sharissa L. Latham, Yolande E.I. O'Donnell, David R. Croucher

Biochem Soc Trans (2022) 50 (6): 1823–1836.

DOI: https://doi.org/10.1042/BST20220808

Published: 01 December 2022

...Sharissa L. Latham; Yolande E.I. O'Donnell; David R. Croucher c-Jun N-terminal Kinases (JNKs) have been identified as key disease drivers in a number of pathophysiological settings and central oncogenic signaling nodes in various cancers. Their roles in driving primary tumor growth, positively...

View article titled, Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments

Articles

Cancer cells hijack RNA processing to rewrite the message

Katherine L.B. Borden

Biochem Soc Trans (2022) 50 (5): 1447–1456.

DOI: https://doi.org/10.1042/BST20220621

Published: 25 October 2022

...Katherine L.B. Borden Typically, cancer is thought to arise due to DNA mutations, dysregulated transcription and/or aberrant signalling. Recently, it has become clear that dysregulated mRNA processing, mRNA export and translation also contribute to malignancy. RNA processing events result in major...

View article titled, Cancer cells hijack RNA processing to rewrite the message

Articles

Last but not least: BFL-1 as an emerging target for anti-cancer therapies

Gaoyuan Wang, Sarah T. Diepstraten, Marco J. Herold

Biochem Soc Trans (2022) 50 (4): 1119–1128.

DOI: https://doi.org/10.1042/BST20220153

Published: 28 July 2022

...Gaoyuan Wang; Sarah T. Diepstraten; Marco J. Herold BFL-1 is an understudied pro-survival BCL-2 protein. The expression of BFL-1 is reported in many cancers, but it is yet to be clarified whether high transcript expression also always correlates with a pro-survival function. However, recent...

View article titled, Last but not least: BFL-1 as an emerging target for anti-cancer therapies

Articles

Tumour invasion and dissemination

Ryan Lusby, Philip Dunne, Vijay K. Tiwari

Biochem Soc Trans (2022) 50 (3): 1245–1257.

DOI: https://doi.org/10.1042/BST20220452

Published: 17 June 2022

...Ryan Lusby; Philip Dunne; Vijay K. Tiwari Activating invasion and metastasis are one of the primary hallmarks of cancer, the latter representing the leading cause of death in cancer patients. Whilst many advances in this area have been made in recent years, the process of cancer dissemination...

View article titled, Tumour invasion and dissemination

Articles

Daylight-PDT: everything under the sun

Dana Beiki, Ian M. Eggleston, Charareh Pourzand

Biochem Soc Trans (2022) 50 (2): 975–985.

DOI: https://doi.org/10.1042/BST20200822

Published: 06 April 2022

...Dana Beiki; Ian M. Eggleston; Charareh Pourzand 5-Aminolevulinic acid-based photodynamic therapy (ALA-PDT) was first implemented over three decades ago and has since been mainly part of clinical practice for the management of pre-cancerous and cancerous skin lesions. Photodynamic therapy relies...

View article titled, Daylight-PDT: everything under the sun

Articles

Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance

Adithya Balasubramanian, Thomas John, Marie-Liesse Asselin-Labat

Biochem Soc Trans (2022) 50 (2): 825–837.

DOI: https://doi.org/10.1042/BST20210961

Published: 28 March 2022

...Adithya Balasubramanian; Thomas John; Marie-Liesse Asselin-Labat Evading immune destruction is one of the hallmarks of cancer. A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. MHC-I and MHC...

View article titled, Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance

Articles

The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation

Daria Sicari, Janine Weber, Elena Maspero, Simona Polo

Biochem Soc Trans (2022) 50 (1): 473–485.

DOI: https://doi.org/10.1042/BST20210731

Published: 07 February 2022

... and discuss new strategies to effectively target this E3 enzyme. Correspondence: Simona Polo ( simona.polo@ifom.eu ) 4 11 2021 18 1 2022 18 1 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 cancer E3 ubiquitin-protein...

View article titled, The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation

Articles

Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics

Matthew J. A. Hein, Marc Kvansakul, Fung T. Lay, Thanh Kha Phan, Mark D. Hulett

Biochem Soc Trans (2022) 50 (1): 423–437.

DOI: https://doi.org/10.1042/BST20200884

Published: 11 January 2022

... and cancer treatments, defensins uniquely target specific membrane lipids via mechanisms distinct from other HDPs. Therefore, defensins could be potentially developed as therapeutics with increased selectivity and reduced susceptibility to the resistance mechanisms of tumour cells and infectious pathogens...

View article titled, Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics

Articles

The role of chromatin at transcription-replication conflicts as a genome safeguard

Aleix Bayona-Feliu, Andrés Aguilera

Biochem Soc Trans (2021) 49 (6): 2727–2736.

DOI: https://doi.org/10.1042/BST20210691

Published: 25 November 2021

... integrity. Increasing evidence indicates that chromatin homeostasis plays a key role in the cellular response to TRCs as well as in the preservation of genome integrity. Indeed, chromatin regulating enzymes are frequently mutated in cancer cells, a common characteristic of which is genome instability...

View article titled, The role of chromatin at transcription-replication conflicts as a genome safeguard

Articles

Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface

Shannon R. Tracey, Peter Smyth, Caroline J. Barelle, Christopher J. Scott

Biochem Soc Trans (2021) 49 (5): 2253–2269.

DOI: https://doi.org/10.1042/BST20210343

Published: 28 October 2021

...Shannon R. Tracey; Peter Smyth; Caroline J. Barelle; Christopher J. Scott Interest in nanomedicines has grown rapidly over the past two decades, owing to the promising therapeutic applications they may provide, particularly for the treatment of cancer. Personalised medicine and ‘smart’ actively...

View article titled, Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface

Articles

Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer

Marie Sorbara, Nicolas Bery

Biochem Soc Trans (2021) 49 (5): 2021–2035.

DOI: https://doi.org/10.1042/BST20201059

Published: 08 October 2021

...Marie Sorbara; Nicolas Bery The RAS superfamily of small GTPases regulates major physiological cellular processes. Mutation or deregulation of these small GTPases, their regulators and/or their effectors are associated with many diseases including cancer. Hence, targeting these classes of proteins...

View article titled, Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer

Articles

Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers

In Collection

Cell death and survival

W. Douglas Fairlie, Erinna F. Lee

Biochem Soc Trans (2021) 49 (5): 2397–2410.

DOI: https://doi.org/10.1042/BST20210750

Published: 28 September 2021

...W. Douglas Fairlie; Erinna F. Lee The deregulation of apoptosis is a key contributor to tumourigenesis as it can lead to the unwanted survival of rogue cells. Drugs known as the BH3-mimetics targeting the pro-survival members of the BCL-2 protein family to induce apoptosis in cancer cells have...

View article titled, Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers

Articles

Are cachexia-associated tumors transmitTERS of ER stress?

Ana Sayuri Yamagata, Paula Paccielli Freire

Biochem Soc Trans (2021) 49 (4): 1841–1853.

DOI: https://doi.org/10.1042/BST20210496

Published: 02 August 2021

...Ana Sayuri Yamagata; Paula Paccielli Freire Cancer cachexia is associated with deficient response to chemotherapy. On the other hand, the tumors of cachectic patients remarkably express more chemokines and have higher immune infiltration. For immunogenicity, a strong induction of the unfolded...

View article titled, Are cachexia-associated tumors transmitTERS of ER stress?

Articles

Molecular subversion of Cdc42 signalling in cancer

Natasha P. Murphy, Ana Masara binti Ahmad Mokhtar, Helen R. Mott, Darerca Owen

Biochem Soc Trans (2021) 49 (3): 1425–1442.

DOI: https://doi.org/10.1042/BST20200557

Published: 01 July 2021

... GTPases in the context of the membrane. The role of Cdc42 in cancer is well established but the molecular details of its action are still being uncovered. Here we review alterations found to Cdc42 itself and to key components of the signal transduction pathways it controls in cancer. Given the challenges...

View article titled, Molecular subversion of Cdc42 signalling in cancer

Articles

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape

Lan-Hsin Wang, Marvin Angelo E. Aberin, Sean Wu, Shu-Ping Wang

Biochem Soc Trans (2021) 49 (3): 1041–1054.

DOI: https://doi.org/10.1042/BST20191164

Published: 22 June 2021

... of enhancer function could be the main cause of tissue-specific cancer development. MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation. Importantly...

View article titled, The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape

Articles

Regulation of MST complexes and activity via SARAH domain modifications

Sofiia Karchugina, Dorothy Benton, Jonathan Chernoff

Biochem Soc Trans (2021) 49 (2): 675–683.

DOI: https://doi.org/10.1042/BST20200559

Published: 16 April 2021

...). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer dimerization hippo pathway protein kinases SARAH domain signal transduction The Hippo pathway was originally discovered in Drosophila from genetic screens designed to identify pathways the regulate...

View article titled, Regulation of MST complexes and activity via SARAH domain modifications

Articles

Aberrant protein glycosylation in cancer: implications in targeted therapy

Joana G. Rodrigues, Henrique O. Duarte, Celso A. Reis, Joana Gomes

Biochem Soc Trans (2021) 49 (2): 843–854.

DOI: https://doi.org/10.1042/BST20200763

Published: 11 March 2021

...Joana G. Rodrigues; Henrique O. Duarte; Celso A. Reis; Joana Gomes Aberrant cell surface glycosylation signatures are currently known to actively drive the neoplastic transformation of healthy cells. By disrupting the homeostatic functions of their protein carriers, cancer-associated glycans...

View article titled, Aberrant protein glycosylation in cancer: implications in targeted therapy

Articles

CHCHD4 (MIA40) and the mitochondrial disulfide relay system

Hasan Al-Habib, Margaret Ashcroft

Biochem Soc Trans (2021) 49 (1): 17–27.

DOI: https://doi.org/10.1042/BST20190232

Published: 18 February 2021

... and transcriptional networks. In this way, mitochondria are central to the cell's homeostatic machinery, and as such mitochondrial dysfunction underlies the pathology of a diverse range of diseases including mitochondrial disease and cancer. Mitochondrial import pathways and targeting mechanisms provide the means...

View article titled, CHCHD4 (MIA40) and the mitochondrial disulfide relay system

Articles

Mechanistic insights into KDM4A driven genomic instability

Nicolas L. Young, Ruhee Dere

Biochem Soc Trans (2021) 49 (1): 93–105.

DOI: https://doi.org/10.1042/BST20191219

Published: 25 January 2021

... that belongs to the Fe-II dependent dioxygenase family that uses α-ketoglutarate and molecular oxygen as cofactors, is overexpressed in several cancers and is associated with an overall poor prognosis. KDM4A demethylates lysine 9 (H3K9me2/3) and lysine 36 (H3K36me3) methyl marks on histone H3. Given...

View article titled, Mechanistic insights into KDM4A driven genomic instability

Articles

CRISPR base editing applications for identifying cancer-driving mutations

Martin Pal, Marco J. Herold

Biochem Soc Trans (2021) 49 (1): 269–280.

DOI: https://doi.org/10.1042/BST20200550

Published: 15 January 2021

... response. Given many cancers originate from point mutations in cancer-driving genes, the application of base editing for either modelling tumour development, therapeutic editing, or functional screening is of great promise. In this review, we summarise current DNA base editing technologies and will discuss...

View article titled, CRISPR base editing applications for identifying cancer-driving mutations

Articles

KRAS G12C inhibitor: combing for combination

Atanu Chakraborty

Biochem Soc Trans (2020) 48 (6): 2691–2701.

DOI: https://doi.org/10.1042/BST20200473

Published: 26 November 2020

...Atanu Chakraborty Oncogenic mutation in KRAS is one of the most common alterations in human cancer. After decades of extensive research and unsuccessful drug discovery programs, therapeutic targeting of KRAS mutant tumour is at an exciting juncture. The discovery of mutation-specific inhibitors...

View article titled, KRAS G12C inhibitor: combing for combination

Articles

Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease

Joe Maltas, Hannah Reed, Andrew Porter, Angeliki Malliri

Biochem Soc Trans (2020) 48 (6): 2703–2719.

DOI: https://doi.org/10.1042/BST20200481

Published: 16 November 2020

... and survival, mainly through activating and directing Rac1 signalling. Dysregulation of the Tiam GEFs is significantly associated with human diseases including cancer, immunological and neurological disorders. Uncovering the mechanisms and consequences of dysregulation is therefore imperative to improving...

View article titled, Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease

Articles

Inhibition of RAS: proven and potential vulnerabilities

Mariyam Zuberi, Imran Khan, John P. O'Bryan

Biochem Soc Trans (2020) 48 (5): 1831–1841.

DOI: https://doi.org/10.1042/BST20190023

Published: 01 September 2020

...Mariyam Zuberi; Imran Khan; John P. O'Bryan RAS is a membrane localized small GTPase frequently mutated in human cancer. As such, RAS has been a focal target for developing cancer therapeutics since its discovery nearly four decades ago. However, efforts to directly target RAS have been challenging...

View article titled, Inhibition of RAS: proven and potential vulnerabilities

Articles

Epigenetic plasticity, selection, and tumorigenesis

William A. Flavahan

Biochem Soc Trans (2020) 48 (4): 1609–1621.

DOI: https://doi.org/10.1042/BST20191215

Published: 14 August 2020

...William A. Flavahan Epigenetic processes converge on chromatin in order to direct a cell's gene expression profile. This includes both maintaining a stable cell identity, but also priming the cell for specific controlled transitions, such as differentiation or response to stimuli. In cancer...

View article titled, Epigenetic plasticity, selection, and tumorigenesis

Articles

The constitutive activity of the viral-encoded G protein-coupled receptor US28 supports a complex signalling network contributing to cancer development

Carole A. Daly, Martine J. Smit, Bianca Plouffe

Biochem Soc Trans (2020) 48 (4): 1493–1504.

DOI: https://doi.org/10.1042/BST20190988

Published: 11 August 2020

... exhibits a particularly high constitutive activity robustly modulating a wide network of cellular pathways altering the host cell environment to benefit HCMV infection. Several studies suggest that US28-mediated signalling may contribute to cancer progression. In this review, we discuss the unique...

View article titled, The constitutive activity of the viral-encoded G protein-coupled receptor US28 supports a complex signalling network contributing to cancer development

Articles

The structural biology of canonical Wnt signalling

Mark Agostino, Sebastian Öther-Gee Pohl

Biochem Soc Trans (2020) 48 (4): 1765–1780.

DOI: https://doi.org/10.1042/BST20200243

Published: 29 July 2020

... for structure-based drug design efforts targeting canonical Wnt signalling. beta-catenin cancer crystallography frizzled glycogen synthase kinase Wnt proteins Correspondence: Mark Agostino ( Mark.Agostino@curtin.edu.au ) or Sebastian Öther-Gee Pohl ( Sebastian.pohl@igmm.ed.ac.uk ) 26 5...

View article titled, The structural biology of canonical Wnt signalling

Articles

The evolution of multicellularity and cancer: views and paradigms

Aurora M. Nedelcu

Biochem Soc Trans (2020) 48 (4): 1505–1518.

DOI: https://doi.org/10.1042/BST20190992

Published: 17 July 2020

... that, in a particular microenvironment, confer mutant lineages a fitness advantage relative to normal somatic cells do occur, and can result in cancer. This minireview highlights several views and paradigms that relate the evolution of multicellularity to cancer. As a phenomenon, cancer is generally understood...

View article titled, The evolution of multicellularity and cancer: views and paradigms

Articles

Inhibitors in AKTion: ATP-competitive vs allosteric

Glorianne Lazaro, Eleftherios Kostaras, Igor Vivanco

Biochem Soc Trans (2020) 48 (3): 933–943.

DOI: https://doi.org/10.1042/BST20190777

Published: 26 May 2020

...Glorianne Lazaro; Eleftherios Kostaras; Igor Vivanco Aberrant activation of the PI3K pathway is one of the commonest oncogenic events in human cancer. AKT is a key mediator of PI3K oncogenic function, and thus has been intensely pursued as a therapeutic target. Multiple AKT inhibitors, broadly...

View article titled, Inhibitors in AKTion: ATP-competitive vs allosteric

Articles

Towards the routine use of in silico screenings for drug discovery using metabolic modelling

Tamara Bintener, Maria Pires Pacheco, Thomas Sauter

Biochem Soc Trans (2020) 48 (3): 955–969.

DOI: https://doi.org/10.1042/BST20190867

Published: 05 May 2020

...Tamara Bintener; Maria Pires Pacheco; Thomas Sauter Currently, the development of new effective drugs for cancer therapy is not only hindered by development costs, drug efficacy, and drug safety but also by the rapid occurrence of drug resistance in cancer. Hence, new tools are needed to study...

View article titled, Towards the routine use of in silico screenings for drug discovery using metabolic modelling

Includes: Supplementary data

Articles

Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer

Davide M. Ferraris, Edoardo L. M. Gelardi, Silvia Garavaglia, Riccardo Miggiano, Menico Rizzi

Biochem Soc Trans (2020) 48 (2): 693–707.

DOI: https://doi.org/10.1042/BST20191261

Published: 20 April 2020

...Davide M. Ferraris; Edoardo L. M. Gelardi; Silvia Garavaglia; Riccardo Miggiano; Menico Rizzi Dehydrogenases are oxidoreductase enzymes that play a variety of fundamental functions in the living organisms and have primary roles in pathogen survival and infection processes as well as in cancer...

View article titled, Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer

Articles

MicroRNAs and long non-coding RNAs as novel regulators of ribosome biogenesis

Mason A. McCool, Carson J. Bryant, Susan J. Baserga

Biochem Soc Trans (2020) 48 (2): 595–612.

DOI: https://doi.org/10.1042/BST20190854

Published: 08 April 2020

..., as in cancer. In time, we hypothesize that many more ncRNA regulators of ribosome biogenesis will be discovered, which will be followed by an effort to establish connections between disease pathologies and the molecular mechanisms of this additional layer of ribosome biogenesis control. Figure 1. Ribosome...

View article titled, MicroRNAs and long non-coding RNAs as novel regulators of ribosome biogenesis

Articles

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

Jia Jin Hiu, Michelle Khai Khun Yap

Biochem Soc Trans (2020) 48 (2): 719–731.

DOI: https://doi.org/10.1042/BST20200110

Published: 08 April 2020

... different venoms demonstrate considerable cytotoxic effects on cancer cells via induction of apoptosis, cell cycle arrest and suppression of proliferation. These enzymes produce more pronounced cytotoxic effects in cancer cells than normal cells, thus they can be potential sources as chemotherapeutic agents...

View article titled, Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

Articles

Small molecule targeting of SHIP1 and SHIP2

William G. Kerr, Chiara Pedicone, Shawn Dormann, Angela Pacherille, John D. Chisholm

Biochem Soc Trans (2020) 48 (1): 291–300.

DOI: https://doi.org/10.1042/BST20190775

Published: 12 February 2020

... that are in dire need of new therapeutic targets. These include cancer, immunotherapy, diabetes, obesity, and Alzheimer's disease. In this mini-review, we will provide a brief overview of research in these areas that support targeting SHIP1, SHIP2 or both enzymes for therapeutic purposes. Correspondence...

View article titled, Small molecule targeting of SHIP1 and SHIP2

Articles

PI3K in stemness regulation: from development to cancer

Ralitsa R. Madsen

Biochem Soc Trans (2020) 48 (1): 301–315.

DOI: https://doi.org/10.1042/BST20190778

Published: 03 February 2020

... features and therapeutic failure in cancer. The aim of this review is to summarise current known and unknowns of PI3K-dependent stemness regulation, by integrating knowledge from the fields of developmental, signalling and cancer biology. Particular attention is given to the role of the PI3K pathway...

View article titled, PI3K in stemness regulation: from development to cancer

Articles

Targeting the lysyl oxidases in tumour desmoplasia

Jessica L. Chitty, Yordanos F.I. Setargew, Thomas R. Cox

Biochem Soc Trans (2019) 47 (6): 1661–1678.

DOI: https://doi.org/10.1042/BST20190098

Published: 22 November 2019

...Jessica L. Chitty; Yordanos F.I. Setargew; Thomas R. Cox The extracellular matrix (ECM) is a fundamental component of tissue microenvironments and its dysregulation has been implicated in a number of diseases, in particular cancer. Tumour desmoplasia (fibrosis) accompanies the progression of many...

View article titled, Targeting the lysyl oxidases in tumour desmoplasia

Articles

Fostering open collaboration in drug development for paediatric brain tumours

Jong Fu Wong, Elizabeth J. Brown, Eleanor Williams, Alex N. Bullock

Biochem Soc Trans (2019) 47 (5): 1471–1479.

DOI: https://doi.org/10.1042/BST20190315

Published: 24 September 2019

...Jong Fu Wong; Elizabeth J. Brown; Eleanor Williams; Alex N. Bullock Brain tumours have become the leading cause of child mortality from cancer. Indeed, aggressive brainstem tumours, such as diffuse intrinsic pontine glioma (DIPG), are nearly uniformly fatal. These tumours display a unique set...

View article titled, Fostering open collaboration in drug development for paediatric brain tumours

Articles

Targeting centrosome amplification, an Achilles' heel of cancer

Dorota Sabat-Pośpiech, Kim Fabian-Kolpanowicz, Ian A. Prior, Judy M. Coulson, Andrew B. Fielding

Biochem Soc Trans (2019) 47 (5): 1209–1222.

DOI: https://doi.org/10.1042/BST20190034

Published: 10 September 2019

...Dorota Sabat-Pośpiech; Kim Fabian-Kolpanowicz; Ian A. Prior; Judy M. Coulson; Andrew B. Fielding Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment of centrosomes, a state referred to as centrosome amplification (CA). CA can drive oncogenic phenotypes...

View article titled, Targeting centrosome amplification, an Achilles' heel of cancer

Articles

A model for the aberrant DNA methylomes in aging cells and cancer cells

Huiming Zhang, Kang Zhang, Jian-Kang Zhu

Biochem Soc Trans (2019) 47 (4): 997–1003.

DOI: https://doi.org/10.1042/BST20180218

Published: 18 July 2019

... and mammals, a pattern of global DNA hypomethylation coupled with increased methylation levels at some specific genomic regions arises at specific developmental stages and in certain abnormal cells, such as mammalian aging cells and cancer cells as well as some plant epigenetic mutants. Here we provide...

View article titled, A model for the aberrant DNA methylomes in aging cells and cancer cells

Articles

The role of the 12( S )-HETE/GPR31/12-HETER axis in cancer and ischemia–reperfusion injury

Monica Napolitano

Biochem Soc Trans (2019) 47 (2): 743–754.

DOI: https://doi.org/10.1042/BST20180635

Published: 22 March 2019

... )-hydroxyeicosatetraenoic acid (HETE), an arachidonic acid metabolite, and the role that GPR31/12-HETER-mediated signals play in cancer cell growth, invasion and metastasis, and in liver ischemia–reperfusion (IR) injury. Recent studies shed light and interest on the 12( S )-HETE/GPR31/12-HETER-activated signaling pathways...

View article titled, The role of the 12( S )-HETE/GPR31/12-HETER axis in cancer and ischemia–reperfusion injury

Articles

Biological relevance of cell-in-cell in cancers

Hannah L. Mackay, Patricia A.J. Muller

Biochem Soc Trans (2019) 47 (2): 725–732.

DOI: https://doi.org/10.1042/BST20180618

Published: 08 March 2019

... cells (heterotypic) or immune cells inside tumour cells (heterotypic). CIC formation can occur in cell lines and in tissues and it has been most frequently observed during inflammation and in cancers. Over the past 10 years, many researchers have studied CIC structures and a few different models have...

View article titled, Biological relevance of cell-in-cell in cancers

Articles

On fitness: how do mutations shape the biology of cancer?

Ian J. Majewski

Biochem Soc Trans (2019) 47 (2): 559–569.

DOI: https://doi.org/10.1042/BST20180224

Published: 08 March 2019

...Ian J. Majewski The theory of evolution by natural selection shapes our understanding of the living world. While natural selection has given rise to all the intricacies of life on the planet, those responsible for treating cancer have a darker view of adaptation and selection. Revolutionary changes...

View article titled, On fitness: how do mutations shape the biology of cancer?

Articles

The role of the interleukin (IL)-6/IL-6 receptor axis in cancer

Mustafa Yassin Taher, David Marc Davies, John Maher

Biochem Soc Trans (2018) 46 (6): 1449–1462.

DOI: https://doi.org/10.1042/BST20180136

Published: 22 November 2018

... of transcription) and other signalling pathways are activated as a consequence. Of translational relevance, overexpression of IL-6 has been documented in several neoplastic disorders, including but not limited to colorectal, ovarian and breast cancer and several haematological malignancies. This review attempts...

View article titled, The role of the interleukin (IL)-6/IL-6 receptor axis in cancer

Articles

Platelets in cancer development and diagnosis

Annalisa Contursi, Rosalia Grande, Melania Dovizio, Annalisa Bruno, Rosa Fullone, Paola Patrignani

Biochem Soc Trans (2018) 46 (6): 1517–1527.

DOI: https://doi.org/10.1042/BST20180159

Published: 12 November 2018

...Annalisa Contursi; Rosalia Grande; Melania Dovizio; Annalisa Bruno; Rosa Fullone; Paola Patrignani Platelets are involved in the development and progression of cancer through several mechanisms. Platelet activation at the site of tissue damage contributes to the initiation of a cascade of events...

View article titled, Platelets in cancer development and diagnosis

Articles

PARPs in genome stability and signal transduction: implications for cancer therapy

Luca Palazzo, Ivan Ahel

Biochem Soc Trans (2018) 46 (6): 1681–1695.

DOI: https://doi.org/10.1042/BST20180418

Published: 12 November 2018

... the understanding of these pathways has provided some major breakthroughs in the treatment of human cancer. Correspondence: Luca Palazzo ( l.palazzo@ibp.cnr.it ) or Ivan Ahel ( ivan.ahel@path.ox.ac.uk ) 26 7 2018 15 9 2018 21 9 2018 © 2018 The Author(s) 2018 This is an open access...

View article titled, PARPs in genome stability and signal transduction: implications for cancer therapy

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