...Grace Kennedy; Olivia Gibson; Dáire T. O'Hare; Ian G. Mills; Emma Evergren Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine-protein kinase, that is involved in maintaining various physiological and cellular processes within the cell that regulate energy...

... for the spreading of tau pathology in these neurodegenerative disorders. 1 To whom correspondence should be addressed (email javila@cbm.uam.es ). 12 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 calmodulin extracellular tau tau secretion ventral dentate...

...–cell adhesion, cytokinesis and apoptosis. These processes rely on protein–protein interactions, and understanding these (and how they influence one another) is critical in determining how the IQGAPs function. A key group of interactions is with calmodulin and the structurally related proteins myosin...

... versatility among PMCA isoforms, with specific pumps being essential for cochlear hair cell function, sperm motility, feedback signalling in the heart and pre- and post-synaptic Ca 2+ regulation in neurons. The functional versatility of PMCAs is due to differences in their regulation by CaM (calmodulin...

..., can sequester calmodulin for its own regulatory purposes. These devices are a sampling of the multiple layers of organization that are in place – even in a simple cell – to ensure faithful and economical communication of the cAMP message. 1 To whom correspondence should be addressed (email...

.... The organelles could trade calcium (e.g. from the ER to mitochondria and vice versa) almost depriving this ion the light of the cytosol and noble company of cytosolic calcium buffers. Altogether it is a rich and colourful story. acetylcholine calcium signalling calcium-binding protein calmodulin...

... 30864 30872 29 Buxton I.L. Brunton L.L. J. Biol. Chem. 1983 258 10233 10239 30 Jurevicius J. Fischmeister R. Proc. Natl. Acad. Sci. U.S.A. 1996 93 295 299 adenylate cyclase A-kinase anchoring protein (AKAP) calmodulin capacitative Ca 2+ entry...

... and 3) and group III (4, 6–8) mGluRs. In the present study, we used a Y2H (yeast two hybrid) screen to identify proteins that interact with the C-terminal intracellular tail of mGluR3. Prominent among the candidate receptor interacting proteins was calmodulin, a Ca 2+ sensor known to bind identifiable...

... April 2003 © 2003 Biochemical Society 2003 adenylate cyclase calmodulin calcium cAMP-dependent protein kinase caveolae phosphodiesterase Abbreviations used: AC1, AC2, AC3, etc., adenylate cyclase types 1, 2, 3, etc; CCE, capacitative Ca 2+ entry; [Ca 2+ ] i , intracellular...

... binding of calmodulin (CaM) at elevated intracellular Ca 2+ levels to produce NO as part of a number of cell signalling pathways. CaM binds to the linker region between the two domains and activates the enzyme by inducing intramolecular electron transfer. Protein-engineering experiments have shown...