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Keywords: calcium signalling
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Articles
Biochem Soc Trans (2018) 46 (6): 1743–1751.
Published: 12 November 2018
... regulation calcium signalling helminths schistosomes Calcium (Ca 2+ ) functions as a central molecule in signal transduction and is one of the most widely used second messengers in cell signalling [ 1 ]. Ca 2+ signalling is important in many cellular processes, including regulation of gene...
Articles
Biochem Soc Trans (2016) 44 (4): 1005–1010.
Published: 15 August 2016
... as selective pressures drive evolution [ 21 ]. There is limited research into alternative treatments for parasitic worm infections and there is also a lack of knowledge about the fundamental biochemistry of these organisms. Consequently, there is a need to understand systems such as calcium signalling...
Articles
Biochem Soc Trans (2016) 44 (2): 467–473.
Published: 11 April 2016
...: calcium signalling and phosphoinositide processing. 1 To whom correspondence should be addressed (email dickson2@uw.edu ). 7 1 2016 © 2016 Authors; published by Portland Press Limited 2016 This mini-review considers the role of endoplasmic reticulum–membrane contact sites...
Articles
Biochem Soc Trans (2015) 43 (3): 405–409.
Published: 01 June 2015
...-evoked signals, which may instead be mediated by activation of ryanodine receptors (RyRs). A prime candidate for mediating this coupling between I-mGluR activation and RyR opening is cyclic ADP ribose (cADPR) and, indeed, several of these PLC-/IP 3 -independent I-mGluR-evoked calcium signals have now...
Articles
Biochem Soc Trans (2015) 43 (3): 371–376.
Published: 01 June 2015
... [ 3 , 4 ]. calcium signalling fertilization infertility phospholipase C (PLC) phospholipase C zeta (PLCζ) sperm Several hypotheses have been proposed to explain the generation of Ca 2+ oscillations in mammalian eggs at fertilization (for the proposed hypotheses see review [ 3...
Articles
Biochem Soc Trans (2015) 43 (3): 410–416.
Published: 01 June 2015
... compilation © 2015 Biochemical Society 2015 atrial fibrillation calcium signalling cardiac arrhythmia lung slice pulmonary vein myocyte Atrial fibrillation (AF) is the most common form of cardiac arrhythmia, with a prevalence of 1%–2% of the general population [ 1 ]. The risk of developing...
Articles
Biochem Soc Trans (2015) 43 (3): 417–425.
Published: 01 June 2015
... accession code 4TMF. 1 To whom correspondence should be addressed (email j.swarbrick@bath.ac.uk or b.v.l.potter@bath.ac.uk , barry.potter@pharm.ox.ac.uk ) . 12 12 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 adenophostin A calcium signalling cyclic...
Articles
Biochem Soc Trans (2014) 42 (6): 1538–1542.
Published: 17 November 2014
... © 2014 Biochemical Society 2014 calcium signalling confocal microscopy fluorescent protein fluorescence resonance energy transfer sensor (FRET sensor) lipid signalling signal transduction Owing to the highly conserved kinase domain of PKCs [ 7 ], in general, the specificity...
Articles
Biochem Soc Trans (2014) 42 (1): 63–70.
Published: 23 January 2014
... calcium signalling cAMP endoplasmic reticulum inositol 1 4 5-trisphosphate receptor (IP 3 receptor) lysosome ryanodine receptor Thirty years ago, and in the face of a commonly held belief that mitochondria were the major intracellular Ca 2+ stores, IP 3 (inositol 1,4,5-trisphosphate...
Articles
Biochem Soc Trans (2012) 40 (5): 1140–1146.
Published: 19 September 2012
... © 2012 Biochemical Society 2012 calcium signalling endolysosome leucine-rich repeat kinase 2 (LRRK2) nicotinic acid–adenine dinucleotide phosphate (NAADP) Parkinson's disease Rab protein Although the molecular mechanism(s) of LRRK2 function remain unclear, at the cellular level...
Articles
Biochem Soc Trans (2012) 40 (1): 147–152.
Published: 19 January 2012
.... Jakobs K.H. A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase Nat. Cell Biol. 2001 3 1020 1024 Secondly, different analogues of PTH cause PTHR1 to adopt different conformations and thereby to interact selectively with different downstream...
Articles
Biochem Soc Trans (2012) 40 (1): 282–286.
Published: 19 January 2012
... correspondence should be addressed (email ajs21@st-andrews.ac.uk ). 15 6 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Alzheimer's disease calcium signalling neural process neuron phospholipase Cη (PLCη) PLC (phospholipase C) enzymes have pivotal roles...
Articles
Biochem Soc Trans (2012) 40 (1): 108–111.
Published: 19 January 2012
.... Finally, we highlight some unresolved questions stemming from recent observations of co-localization and co-immunoprecipitation of IP 3 receptors with Orai channels in the apical (secretory) region of pancreatic acinar cells. calcium signalling inositol 1,4,5-trisphosphate receptor Orai1...
Articles
Biochem Soc Trans (2012) 40 (1): 112–118.
Published: 19 January 2012
... compilation © 2012 Biochemical Society 2012 calcium signalling endoplasmic reticulum ion channel Orai store-operated calcium entry (SOCE) stromal interaction molecule (STIM) STIM proteins were initially described as adhesion proteins involved in intercellular interactions [ 43...
Articles
Biochem Soc Trans (2011) 39 (3): 789–797.
Published: 20 May 2011
... Biochemical Society 2011 anticancer drug Ca 2+ -ATPase calcium pump inhibitor calcium signalling sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA) For more than 40 years, there has been considerable research into molecules that can affect the activity of one of the most extensively...
Articles
Biochem Soc Trans (2010) 38 (5): 1270–1274.
Published: 24 September 2010
... 2010 Biochemical Society 2010 calcium signalling chemotaxis fertilization flagellum sea-urchin sperm sperm motility In many species, including mammals, spermatozoa are guided in their journey towards the egg or oocyte by gradients of chemical signals released by the female gamete...
Articles
Biochem Soc Trans (2010) 38 (2): 588–592.
Published: 22 March 2010
.... A total of 50 pollen tubes were measured in three independent experiments (150 in total). Results are means±S.E.M. Figure adapted from [ 5 ] with permission. calcium signalling Papaver pollen programmed cell death S -determinant self-incompatibility ...
Articles
Biochem Soc Trans (2009) 37 (6): 1147–1160.
Published: 19 November 2009
... calcium signalling neurodegeneration neuroprotection N -methyl- D -aspartate receptor (NMDAR) oxidative stress transcription NMDARs [NMDA ( N -methyl- D -aspartate) receptors] are cation-passing channels gated by the neurotransmitter glutamate. They play a central role in synaptic...
Articles
Biochem Soc Trans (2007) 35 (5): 919–922.
Published: 25 October 2007
... in the PMCAs. calcium pump calcium regulation calcium signalling calmodulin plasma-membrane Ca 2+ -ATPase (PMCA) This work was supported in part by NIH (National Institutes of Health) grants GM28835 and NS51769. References 1 Berridge M.J. Bootman M.D. Lipp P. Nature 1998...
Articles
Biochem Soc Trans (2007) 35 (5): 1208–1210.
Published: 25 October 2007
... 2007 Biochemical Society 2007 Figure 1 GKA50-induced calcium signals in mouse β-cells Islet cells from MIP–GFP mice were used to definitively identify β-cells, which were then exposed to 1 μM GKA50 in the presence of 2 mM glucose. Note that the rises in [Ca 2+ ] i (increase in fura 2...
Articles
Biochem Soc Trans (2007) 35 (5): 913–918.
Published: 25 October 2007
... Society 2007 calcium signalling deafness hearing loss plasma-membrane calcium pump The pump isoforms generated by alternative splicing in the C-terminal region (site C) are of particular interest, since the C-terminal tail contains the calmodulin-binding site. This domain, in the absence...
Articles
Biochem Soc Trans (2007) 35 (1): 96–100.
Published: 22 January 2007
... and several others have demonstrated that TRPC1 is assembled in a signalling complex with key calcium signalling proteins in functionally specific plasma membrane microdomains. Furthermore, critical interactions between TRPC1 monomers as well as interactions between TRPC1 and other proteins determine...
Articles
Biochem Soc Trans (2007) 35 (1): 109–114.
Published: 22 January 2007
... nucleotides of the Ap2A-type (adenosine–PP i –adenosine) formed by ADPRC in the presence of adenine; these compounds interfere with Ca 2+ signalling in vitro and display cytotoxic properties [ 16 ]. ADP-ribose (ADPR) cyclic ADP-ribose (cADPR) calcium signalling nicotinic acid–adenine dinucleotide...
Articles
Biochem Soc Trans (2006) 34 (5): 919–921.
Published: 25 October 2006
....), A. Dolphin (University College London, U.K.), J. Henley (Bristol, U.K.), A. Lai (Cardiff, U.K.) and C. Taylor (Cambridge, U.K.). DTT dithiothreitol ROS reactive oxygen species RyR ryanodine receptor SR sarcoplasmic reticulum calcium signalling reactive oxygen species...
Articles
Biochem Soc Trans (2006) 34 (5): 936–938.
Published: 25 October 2006
... 2006 The Biochemical Society 2006 apoptosis calcium signalling cAMP-response element (CRE)-binding protein (CREB) excitotoxicity neuroprotection N -methyl- D -aspartate receptor (NMDA receptor) NMDARs [NMDA ( N -methyl- D -aspartate) receptors] are cation channels, gated...
Articles
Biochem Soc Trans (2006) 34 (3): 381–384.
Published: 22 May 2006
.... The organelles could trade calcium (e.g. from the ER to mitochondria and vice versa) almost depriving this ion the light of the cytosol and noble company of cytosolic calcium buffers. Altogether it is a rich and colourful story. Calcium signalling is a mature field with a well-developed methodology...
Articles
Biochem Soc Trans (2003) 31 (5): 958–959.
Published: 01 October 2003
...C.W. Distelhorst; H.L. Roderick In this review we speculate that the anti-apoptotic protein Bcl-2 may regulate calcium signals involved in mediating cell death. Evidence that Ins(1,4,5) P 3 -mediated calcium release from the endoplasmic reticulum triggers apoptosis in response to diverse signals...
Articles
Biochem Soc Trans (2003) 31 (5): 930–933.
Published: 01 October 2003
... Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003 7 April 2003 © 2003 Biochemical Society 2003 calcium signalling cardiac contraction cardiac hypertrophy gene transcription...
Articles
Biochem Soc Trans (2000) 28 (4): 476–481.
Published: 01 August 2000
... calcium signalling stomata specificity ABA, abscisic acid [Ca 2+ ] cyt , cytosolic free Ca 2+ concentration [Ca 2+ ] ext , external Ca 2+ concentration DAG, diacylglygerol Ins(1,4,5) P 3 R, Ins(1,4,5) P 3 receptor K in , plasma membrane inward-rectifying K + channel PLC, phospholipase...