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Calcium and Ca 2+ /Calmodulin-dependent kinase II as targets for helminth parasite control

Sujeevi S. K. Nawaratna, Hong You, Malcolm K. Jones, Donald P. McManus, Geoffrey N. Gobert

Biochem Soc Trans (2018) 46 (6): 1743–1751.

DOI: https://doi.org/10.1042/BST20180480

Published: 12 November 2018

... regulation calcium signalling helminths schistosomes Calcium (Ca 2+ ) functions as a central molecule in signal transduction and is one of the most widely used second messengers in cell signalling [ 1 ]. Ca 2+ signalling is important in many cellular processes, including regulation of gene...

View article titled, Calcium and Ca 2+ /Calmodulin-dependent kinase II as targets for helminth parasite control

Articles

A mysterious family of calcium-binding proteins from parasitic worms

Charlotte M. Thomas, David J. Timson

Biochem Soc Trans (2016) 44 (4): 1005–1010.

DOI: https://doi.org/10.1042/BST20150270

Published: 15 August 2016

... be addressed (email d.timson@brighton.ac.uk ). 11 2 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 calcium signalling Fasciola hepatica Schistosoma mansoni dynein light chain EF-hand praziquantel Changes...

View article titled, A mysterious family of calcium-binding proteins from parasitic worms

Articles

Regulation of calcium and phosphoinositides at endoplasmic reticulum–membrane junctions

Eamonn J. Dickson, Jill B. Jensen, Bertil Hille

Biochem Soc Trans (2016) 44 (2): 467–473.

DOI: https://doi.org/10.1042/BST20150262

Published: 11 April 2016

...: calcium signalling and phosphoinositide processing. 1 To whom correspondence should be addressed (email dickson2@uw.edu ). 7 1 2016 © 2016 Authors; published by Portland Press Limited 2016 calcium signalling endoplasmic reticulum membrane-membrane junctions organelle contact...

View article titled, Regulation of calcium and phosphoinositides at endoplasmic reticulum–membrane junctions

Articles

Metabotropic glutamate receptor-mediated cyclic ADP ribose signalling

Aidan Kaar, Mark G. Rae

Biochem Soc Trans (2015) 43 (3): 405–409.

DOI: https://doi.org/10.1042/BST20140288

Published: 01 June 2015

...-evoked signals, which may instead be mediated by activation of ryanodine receptors (RyRs). A prime candidate for mediating this coupling between I-mGluR activation and RyR opening is cyclic ADP ribose (cADPR) and, indeed, several of these PLC-/IP 3 -independent I-mGluR-evoked calcium signals have now...

View article titled, Metabotropic glutamate receptor-mediated cyclic ADP ribose signalling

Articles

Novel signalling mechanism and clinical applications of sperm-specific PLCζ

Michail Nomikos

Biochem Soc Trans (2015) 43 (3): 371–376.

DOI: https://doi.org/10.1042/BST20140291

Published: 01 June 2015

... 2015 calcium signalling fertilization infertility phospholipase C (PLC) phospholipase C zeta (PLCζ) sperm At fertilization in mammals, when a sperm fertilizes an oocyte (egg), it delivers not only a package of genes from the father, but it also sends a direct “message” to the egg...

View article titled, Novel signalling mechanism and clinical applications of sperm-specific PLCζ

Articles

Pulmonary vein sleeve cell excitation–contraction-coupling becomes dysynchronized by spontaneous calcium transients

Katja Rietdorf, Said Masoud, Fraser McDonald, Michael J. Sanderson, Martin D. Bootman

Biochem Soc Trans (2015) 43 (3): 410–416.

DOI: https://doi.org/10.1042/BST20140299

Published: 01 June 2015

... © The Authors Journal compilation © 2015 Biochemical Society 2015 atrial fibrillation calcium signalling cardiac arrhythmia lung slice pulmonary vein myocyte Atrial fibrillation (AF) is the most common form of cardiac arrhythmia, with a prevalence of 1%–2% of the general population...

View article titled, Pulmonary vein sleeve cell excitation–contraction-coupling becomes dysynchronized by spontaneous calcium transients

Articles

Designer small molecules to target calcium signalling

Joanna M. Swarbrick, Andrew M. Riley, Stephen J. Mills, Barry V.L. Potter

Biochem Soc Trans (2015) 43 (3): 417–425.

DOI: https://doi.org/10.1042/BST20140293

Published: 01 June 2015

... The Authors Journal compilation © 2015 Biochemical Society 2015 adenophostin A calcium signalling cyclic adenosine 5′-diphosphoribose (cADPR) chemical biology myo -inositol 1,4,5-trisphosphate (IP 3 ) nicotinic acid adenine dinucleotide phosphate (NAADP) Ca 2+ regulates many cellular...

View article titled, Designer small molecules to target calcium signalling

Articles

Differential targeting of cPKC and nPKC decodes and regulates Ca 2+ and lipid signalling

Xin Hui, Lars Kaestner, Peter Lipp

Biochem Soc Trans (2014) 42 (6): 1538–1542.

DOI: https://doi.org/10.1042/BST20140239

Published: 17 November 2014

.... 1 To whom correspondence should be addressed (email peter.lipp@uks.eu ). 2 9 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 calcium signalling confocal microscopy fluorescent protein fluorescence resonance energy transfer sensor (FRET sensor...

View article titled, Differential targeting of cPKC and nPKC decodes and regulates Ca 2+ and lipid signalling

Articles

Structural organization of signalling to and from IP 3 receptors

Colin W. Taylor, Stephen C. Tovey, Ana M. Rossi, Cristina I. Lopez Sanjurjo, David L. Prole, Taufiq Rahman

Biochem Soc Trans (2014) 42 (1): 63–70.

DOI: https://doi.org/10.1042/BST20130205

Published: 23 January 2014

... calcium signalling cAMP endoplasmic reticulum inositol 1 4 5-trisphosphate receptor (IP 3 receptor) lysosome ryanodine receptor Thirty years ago, and in the face of a commonly held belief that mitochondria were the major intracellular Ca 2+ stores, IP 3 (inositol 1,4,5-trisphosphate...

View article titled, Structural organization of signalling to and from IP 3 receptors

Articles

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling

Patricia Gómez-Suaga, Grant C. Churchill, Sandip Patel, Sabine Hilfiker

Biochem Soc Trans (2012) 40 (5): 1140–1146.

DOI: https://doi.org/10.1042/BST20120138

Published: 19 September 2012

... © 2012 Biochemical Society 2012 calcium signalling endolysosome leucine-rich repeat kinase 2 (LRRK2) nicotinic acid–adenine dinucleotide phosphate (NAADP) Parkinson's disease Rab protein PD (Parkinson's disease) is a common age-related neurodegenerative disorder, and recent...

View article titled, A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling

Articles

Cellular geography of IP 3 receptors, STIM and Orai: a lesson from secretory epithelial cells

Hayley Dingsdale, Svetlana Voronina, Lee Haynes, Alexei Tepikin, Gyorgy Lur

Biochem Soc Trans (2012) 40 (1): 108–111.

DOI: https://doi.org/10.1042/BST20110639

Published: 19 January 2012

... ). 14 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium signalling inositol 1,4,5-trisphosphate receptor Orai1 pancreatic acinar cell store-operated calcium entry (SOCE) stromal interaction molecule 1 (STIM1) Pancreatic acinar cells specialize...

View article titled, Cellular geography of IP 3 receptors, STIM and Orai: a lesson from secretory epithelial cells

Articles

Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes

Wei-Wei Shen, Nicolas Demaurex

Biochem Soc Trans (2012) 40 (1): 112–118.

DOI: https://doi.org/10.1042/BST20110620

Published: 19 January 2012

... compilation © 2012 Biochemical Society 2012 calcium signalling endoplasmic reticulum ion channel Orai store-operated calcium entry (SOCE) stromal interaction molecule (STIM) Cytosolic Ca 2+ elevations control a large array of cellular functions, notably the contraction of cardiac...

View article titled, Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes

Articles

From parathyroid hormone to cytosolic Ca 2+ signals

Colin W. Taylor, Stephen C. Tovey

Biochem Soc Trans (2012) 40 (1): 147–152.

DOI: https://doi.org/10.1042/BST20110615

Published: 19 January 2012

...@cam.ac.uk ). 14 6 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 adenylate cyclase calcium signalling cAMP Ins P 3 receptor parathyroid hormone stimulus trafficking PTH plays a central role in regulating turnover of bone and in plasma Ca 2...

View article titled, From parathyroid hormone to cytosolic Ca 2+ signals

Articles

Putative roles for phospholipase Cη enzymes in neuronal Ca 2+ signal modulation

Petra Popovics, Alan J. Stewart

Biochem Soc Trans (2012) 40 (1): 282–286.

DOI: https://doi.org/10.1042/BST20110622

Published: 19 January 2012

... correspondence should be addressed (email ajs21@st-andrews.ac.uk ). 15 6 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Alzheimer's disease calcium signalling neural process neuron phospholipase Cη (PLCη) PLC (phospholipase C) enzymes have pivotal roles...

View article titled, Putative roles for phospholipase Cη enzymes in neuronal Ca 2+ signal modulation

Articles

A diversity of SERCA Ca 2+ pump inhibitors

Francesco Michelangeli, J. Malcolm East

Biochem Soc Trans (2011) 39 (3): 789–797.

DOI: https://doi.org/10.1042/BST0390789

Published: 20 May 2011

... Biochemical Society 2011 anticancer drug Ca 2+ -ATPase calcium pump inhibitor calcium signalling sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA) For more than 40 years, there has been considerable research into molecules that can affect the activity of one of the most extensively...

View article titled, A diversity of SERCA Ca 2+ pump inhibitors

Articles

Tuning sperm chemotaxis

Adán Guerrero, Christopher D. Wood, Takuya Nishigaki, Jorge Carneiro, Alberto Darszon

Biochem Soc Trans (2010) 38 (5): 1270–1274.

DOI: https://doi.org/10.1042/BST0381270

Published: 24 September 2010

... 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 calcium signalling chemotaxis fertilization flagellum sea-urchin sperm sperm motility In many species, including mammals, spermatozoa are guided in their journey towards the egg or oocyte by gradients...

View article titled, Tuning sperm chemotaxis

Articles

Self-incompatibility in Papaver : identification of the pollen S -determinant PrpS

Natalie S. Poulter, Michael J. Wheeler, Maurice Bosch, Vernonica E. Franklin-Tong

Biochem Soc Trans (2010) 38 (2): 588–592.

DOI: https://doi.org/10.1042/BST0380588

Published: 22 March 2010

..., linked to the pistil S- determinant, and displays the high polymorphism expected of an S- locus determinant. The present review focuses on the discovery and characterization of PrpS which strongly support the hypothesis that Papaver SI is triggered by the interaction of PrsS and PrpS. calcium...

View article titled, Self-incompatibility in Papaver : identification of the pollen S -determinant PrpS

Articles

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Giles E. Hardingham

Biochem Soc Trans (2009) 37 (6): 1147–1160.

DOI: https://doi.org/10.1042/BST0371147

Published: 19 November 2009

... of the NMDA receptor. Increased understanding in this field is leading to the discovery of new therapeutic targets and strategies for excitotoxic disorders, as well as a growing appreciation of the harmful consequences of NMDA receptor blockade. calcium signalling neurodegeneration neuroprotection N...

View article titled, Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Articles

Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells

D. Johnson, R.M. Shepherd, D. Gill, T. Gorman, D.M. Smith, M.J. Dunne

Biochem Soc Trans (2007) 35 (5): 1208–1210.

DOI: https://doi.org/10.1042/BST0351208

Published: 25 October 2007

... 2007 Biochemical Society 2007 calcium signalling glucokinase activator insulin release islet cell pancreatic β-cell GK (EC 2.7.1.1; hexokinase IV or D) catalyses the phosphorylation of glucose to glucose 6-phosphate in glucosensitive cells, including pancreatic β-cells [ 1 ]. GK has...

View article titled, Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells

Articles

Plasma-membrane calcium pumps and hereditary deafness

M. Brini, F. Di Leva, T. Domi, L. Fedrizzi, D. Lim, E. Carafoli

Biochem Soc Trans (2007) 35 (5): 913–918.

DOI: https://doi.org/10.1042/BST0350913

Published: 25 October 2007

... characteristics of the pumps. 1 To whom correspondence should be addressed (email marisa.brini@unipd.it ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium signalling deafness hearing loss plasma-membrane calcium pump Ca 2+ signalling...

View article titled, Plasma-membrane calcium pumps and hereditary deafness

Articles

Plasma-membrane Ca 2+ pumps: structural diversity as the basis for functional versatility

E.E. Strehler, A.G. Filoteo, J.T. Penniston, A.J. Caride

Biochem Soc Trans (2007) 35 (5): 919–922.

DOI: https://doi.org/10.1042/BST0350919

Published: 25 October 2007

... bind to the structurally diverse regions of the PMCAs, including the alternatively spliced C-tail and the N-terminal tail. 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium pump calcium regulation calcium signalling calmodulin plasma-membrane...

View article titled, Plasma-membrane Ca 2+ pumps: structural diversity as the basis for functional versatility

Articles

TRPC1: a core component of store-operated calcium channels

I.S. Ambudkar

Biochem Soc Trans (2007) 35 (1): 96–100.

DOI: https://doi.org/10.1042/BST0350096

Published: 22 January 2007

... and several others have demonstrated that TRPC1 is assembled in a signalling complex with key calcium signalling proteins in functionally specific plasma membrane microdomains. Furthermore, critical interactions between TRPC1 monomers as well as interactions between TRPC1 and other proteins determine...

View article titled, TRPC1: a core component of store-operated calcium channels

Articles

Regulation of calcium signalling by adenine-based second messengers

R. Fliegert, A. Gasser, A.H. Guse

Biochem Soc Trans (2007) 35 (1): 109–114.

DOI: https://doi.org/10.1042/BST0350109

Published: 22 January 2007

... guse@uke.uni-hamburg.de ). 18 8 2006 © 2007 The Biochemical Society 2007 ADP-ribose (ADPR) cyclic ADP-ribose (cADPR) calcium signalling nicotinic acid–adenine dinucleotide phosphate (NAADP) second messenger transient receptor potential melastatin 2 (TRPM2) The first...

View article titled, Regulation of calcium signalling by adenine-based second messengers

Articles

Pro-survival signalling from the NMDA receptor

G.E. Hardingham

Biochem Soc Trans (2006) 34 (5): 936–938.

DOI: https://doi.org/10.1042/BST0340936

Published: 25 October 2006

... 2006 The Biochemical Society 2006 apoptosis calcium signalling cAMP-response element (CRE)-binding protein (CREB) excitotoxicity neuroprotection N -methyl- D -aspartate receptor (NMDA receptor) NMDARs [NMDA ( N -methyl- D -aspartate) receptors] are cation channels, gated...

View article titled, Pro-survival signalling from the NMDA receptor

Articles

Redox regulation of the ryanodine receptor/calcium release channel

S. Zissimopoulos, F.A. Lai

Biochem Soc Trans (2006) 34 (5): 919–921.

DOI: https://doi.org/10.1042/BST0340919

Published: 25 October 2006

.... Chem. 1997 272 25051 25061 40 Liu G. Abramson J. Zable A. Pessah I. Mol. Pharmacol. 1994 45 189 200 41 Zhang J. Wu Y. Williams B. Rodney G. Mandel F. GM S. Hamilton S. Am. J. Physiol. 1999 276 C46 C53 calcium...

View article titled, Redox regulation of the ryanodine receptor/calcium release channel

Articles

Movement of calcium signals and calcium-binding proteins: firewalls, traps and tunnels

S.L. Barrow, M.W. Sherwood, N.J. Dolman, O.V. Gerasimenko, S.G. Voronina, A.V. Tepikin

Biochem Soc Trans (2006) 34 (3): 381–384.

DOI: https://doi.org/10.1042/BST0340381

Published: 22 May 2006

.... The organelles could trade calcium (e.g. from the ER to mitochondria and vice versa) almost depriving this ion the light of the cytosol and noble company of cytosolic calcium buffers. Altogether it is a rich and colourful story. acetylcholine calcium signalling calcium-binding protein calmodulin...

View article titled, Movement of calcium signals and calcium-binding proteins: firewalls, traps and tunnels

Articles

Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?

C.W. Distelhorst, H.L. Roderick

Biochem Soc Trans (2003) 31 (5): 958–959.

DOI: https://doi.org/10.1042/bst0310958

Published: 01 October 2003

...C.W. Distelhorst; H.L. Roderick In this review we speculate that the anti-apoptotic protein Bcl-2 may regulate calcium signals involved in mediating cell death. Evidence that Ins(1,4,5) P 3 -mediated calcium release from the endoplasmic reticulum triggers apoptosis in response to diverse signals...

View article titled, Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?

Articles

Cardiac calcium signalling

M.J. Berridge

Biochem Soc Trans (2003) 31 (5): 930–933.

DOI: https://doi.org/10.1042/bst0310930

Published: 01 October 2003

... Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003 7 April 2003 © 2003 Biochemical Society 2003 calcium signalling cardiac contraction cardiac hypertrophy gene transcription...

View article titled, Cardiac calcium signalling

Articles

Ca 2+ signalling in stomatal guard cells

M. R. McAinsh, J. E. Gray, A. M. Hetherington, C. P. Leckie, C. Ng

Biochem Soc Trans (2000) 28 (4): 476–481.

DOI: https://doi.org/10.1042/bst0280476

Published: 01 August 2000

... calcium signalling stomata specificity ABA, abscisic acid [Ca 2+ ] cyt , cytosolic free Ca 2+ concentration [Ca 2+ ] ext , external Ca 2+ concentration DAG, diacylglygerol Ins(1,4,5) P 3 R, Ins(1,4,5) P 3 receptor K in , plasma membrane inward-rectifying K + channel PLC, phospholipase...

View article titled, Ca 2+ signalling in stomatal guard cells

NARROW

Calcium and Ca 2+ /Calmodulin-dependent kinase II as targets for helminth parasite control

A mysterious family of calcium-binding proteins from parasitic worms

Regulation of calcium and phosphoinositides at endoplasmic reticulum–membrane junctions

Metabotropic glutamate receptor-mediated cyclic ADP ribose signalling

Novel signalling mechanism and clinical applications of sperm-specific PLCζ

Pulmonary vein sleeve cell excitation–contraction-coupling becomes dysynchronized by spontaneous calcium transients

Designer small molecules to target calcium signalling

Differential targeting of cPKC and nPKC decodes and regulates Ca 2+ and lipid signalling

Structural organization of signalling to and from IP 3 receptors

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling

Cellular geography of IP 3 receptors, STIM and Orai: a lesson from secretory epithelial cells

Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes

From parathyroid hormone to cytosolic Ca 2+ signals

Putative roles for phospholipase Cη enzymes in neuronal Ca 2+ signal modulation

A diversity of SERCA Ca 2+ pump inhibitors

Tuning sperm chemotaxis

Self-incompatibility in Papaver : identification of the pollen S -determinant PrpS

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells

Plasma-membrane calcium pumps and hereditary deafness

Plasma-membrane Ca 2+ pumps: structural diversity as the basis for functional versatility

TRPC1: a core component of store-operated calcium channels

Regulation of calcium signalling by adenine-based second messengers

Pro-survival signalling from the NMDA receptor

Redox regulation of the ryanodine receptor/calcium release channel

Movement of calcium signals and calcium-binding proteins: firewalls, traps and tunnels

Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?

Cardiac calcium signalling

Ca 2+ signalling in stomatal guard cells

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