... of helminth and protozoan parasites. Investigations on the molecular regulation of calcium and the role of CaMK are important for both supplementing current drug regimens and finding new antiparasitic compounds. Whereas calcium regulators, including CaMK, are well characterised in mammalian systems, knowledge...

... Alzheimer’s disease calcium regulation calpain lysosome Autosomal dominant mutations of PS1 (presenilin 1), PS2 (presenilin 2) and APP (amyloid precursor protein) cause EOAD (early-onset Alzheimer's disease). Although EOAD accounts for fewer than 5% of all AD cases, investigation of the three genes...

... disorders. calcium regulation endolysosome lysosomal storage disease nicotinic acid–adenine dinucleotide phosphate (NAADP) Niemann–Pick type C disease (NPC disease) two-pore channel (TPC) To date, very few diseases have been associated directly with defects in lysosomal calcium. Those...

....). 1 To whom correspondence should be addressed (email strehler.emanuel@mayo.edu ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium pump calcium regulation calcium signalling calmodulin plasma-membrane Ca 2+ -ATPase (PMCA) Ca 2...

.... 1 To whom correspondence should be addressed (e-mail blopez@cbm.uam.es ). 28 5 2001 © 2001 Biochemical Society 2001 neurotransmitter transporter glycine re-uptake SNARE protein calcium regulation PC12 cell Bont-B/C, botulinum neurotoxins B and C GFP, green fluorescent...