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Keywords: calcium
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Articles
Biochem Soc Trans (2023) 51 (4): 1437–1445.
Published: 30 June 2023
... 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 calcium claudin kidney tight junction tubule One of the primary functions of the kidney is regulating water, solute, and electrolyte homeostasis through the control of tubular transport...
Articles
Biochem Soc Trans (2020) 48 (1): 61–70.
Published: 27 February 2020
...Aleksandra Judina; Julia Gorelik; Peter T. Wright Multiple intra-cellular signalling pathways rely on calcium and 3′–5′ cyclic adenosine monophosphate (cAMP) to act as secondary messengers. This is especially true in cardiomyocytes which act as the force-producing units of the cardiac muscle...
Articles
Biochem Soc Trans (2019) 47 (6): 1963–1969.
Published: 26 November 2019
... of respiration, decrease in ATP level, ROS production increase and abnormal metabolism, that lead to lipid peroxidation (LP) and reduction in GSH level. Slower mitochondrial calcium efflux results in pathologically elevated level of Ca 2+ in mitochondria, and taken together with all the former events open...
Articles
Biochem Soc Trans (2016) 44 (2): 452–459.
Published: 11 April 2016
... ( Figure 1 ). calcium endoplasmic reticulum (ER) inositol 1 4 5-trisphosphate receptor (IP3R) mitochondria-associated membrane (MAM) redox-dependent regulation sarco/endoplasmic reticulum Ca 2+ transport ATPase (SERCA) signal transduction The endoplasmic reticulum (ER) is the major...
Articles
Biochem Soc Trans (2016) 44 (1): 202–211.
Published: 09 February 2016
...Robin Irvine Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5) P 3 as a calcium-mobilizing second messenger was first suggested and then experimentally established. At the same time the unexpected complexity of inositide metabolism began to be exposed by the discovery of Ins...
Articles
Biochem Soc Trans (2016) 44 (1): 1–6.
Published: 09 February 2016
...Noelia Lander; Ciro Cordeiro; Guozhong Huang; Roberto Docampo Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H + -PPase or VP1), the vacuolar proton...
Articles
Biochem Soc Trans (2016) 44 (1): 253–259.
Published: 09 February 2016
... osmolyte. In fact, in archaea, this is the primary function of inositol, present in its di-inositol phosphate form, allowing archaea to adapt to extreme environments [ 19 ]. calcium evolution inositol metabolism phosphate The fine organization of a biological system is constantly...
Articles
Biochem Soc Trans (2016) 44 (1): 7–12.
Published: 09 February 2016
...Maria E. Solesio; Pia A. Elustondo; Eleonora Zakharian; Evgeny V. Pavlov Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological calcium overload leads to the membrane depolarization and disruption...
Articles
Biochem Soc Trans (2015) 43 (3): 349–358.
Published: 01 June 2015
...-2-related factor 2 (Nrf2), which also is key cellular regulator of phenotypic stability. Klotho is included in the hypothesis as it is a similar custodian of multiple cell signalling pathways. Alzheimer's diseases antioxidants calcium cardiac disease Klotho memory phenotypic stability...
Articles
Biochem Soc Trans (2015) 43 (3): 502–507.
Published: 01 June 2015
... by ATP through P2Y receptors and by cytoplasmic calcium FEBS Lett. 2006 580 239 244 10.1016/j.febslet.2005.12.004 16364313 17 Lohman A.W. Weaver J.L. Billaud M. Sandilos J.K. Griffiths R. Straub A.C. Penuela S. Leitinger N. Laird D.W. Bayliss D.A...
Articles
Biochem Soc Trans (2014) 42 (5): 1302–1310.
Published: 18 September 2014
...Terri-Leigh Stephen; Swati Gupta-Agarwal; Josef T. Kittler Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca 2+ ) levels in response to synaptic activity. Astrocyte Ca 2+ elevations can trigger the release of neuroactive substances that can modulate...
Articles
Biochem Soc Trans (2014) 42 (5): 1441–1446.
Published: 18 September 2014
... -binding proteins are known targets of calmodulin (CaM), which, depending on the presence of calcium, can compete with PI(4,5)P 2 for protein interaction, translating Ca 2+ transient microdomains into variations of PI(4,5)P 2 lateral organization in time and space. The present review highlights different...
Articles
Biochem Soc Trans (2012) 40 (2): 297–309.
Published: 21 March 2012
... that abnormal increases in Ins P 3 may explain the development of the arrhythmias that are a major cause of sudden death syndrome. Increases in Ins P 3 are also responsible for the arrhythmogenic action of ET-1 in ventricular cardiac myocytes [ 16 ]. Alzheimer's disease bipolar disorder calcium...
Articles
Biochem Soc Trans (2012) 40 (1): 153–157.
Published: 19 January 2012
... smooth muscle cells NT NT Yes [ 73 ] SKBR3 cells NT Yes NT [ 74 ] Medulla neurons No Yes NT [ 75 ] Hepatic stellate cells Yes Yes Yes [ 76 ] Arterial endothelial cells No Yes NT [ 54 ] calcium endosome lysosome membrane contact site nicotinic acid–adenine...
Articles
Biochem Soc Trans (2012) 40 (1): 44–50.
Published: 19 January 2012
... (email jso22@medschl.cam.ac.uk ). 3 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium cAMP circadian rhythm clock second messenger suprachiasmatic nucleus (SCN) Circadian rhythms are biological oscillations with periods of approximately 1...
Articles
Biochem Soc Trans (2011) 39 (5): 1136–1141.
Published: 21 September 2011
.... 1 To whom correspondence should be addressed (email sellersj@nhlbi.nih.gov ). 29 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 actin ATPase activity calcium myosin The myosin superfamily throughout phylogeny consists of at least 35 classes...
Articles
Biochem Soc Trans (2010) 38 (5): 1319–1321.
Published: 24 September 2010
... adrenaline calcium Modular Control and Regulation Analysis non-invasive 31 P-NMR perfused heart systems biology Top-down or modular approaches to MCA (Metabolic Control Analysis) have been used by us and others to overcome the complexity of investigating intracellular and intra-organ regulation...
Articles
Biochem Soc Trans (2009) 37 (6): 1369–1374.
Published: 19 November 2009
..., MA 02138-2020, U.S.A. 2 To whom correspondence should be addressed (email suzanne.zukin@einstein.yu.edu ). 14 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 calcium N -methyl- D -aspartate receptor (NMDAR) protein kinase signalling synaptic...
Articles
Biochem Soc Trans (2009) 37 (1): 200–203.
Published: 20 January 2009
... described for its capacity to bind to the calcium-binding protein, ALG-2. Alix regulates neuronal death in ways involving interactions with ALG-2 and with proteins of the ESCRT (endosomal sorting complex required for transport). Even though all Alix interactors characterized to date are involved...
Articles
Biochem Soc Trans (2009) 37 (1): 190–194.
Published: 20 January 2009
... ALG-2 (apoptosis-linked gene 2)-interacting protein X (Alix) apoptosis-linked gene 2 (ALG-2) calcium crystal structure penta-EF-hand proline-rich domain Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X]/AIP1 (ALG-2-interacting protein 1), HD-PTP (His domain phosphotyrosine...
Articles
Biochem Soc Trans (2008) 36 (6): 1309–1312.
Published: 19 November 2008
...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...
Articles
Biochem Soc Trans (2007) 35 (5): 1046–1048.
Published: 25 October 2007
... The Authors Journal compilation © 2007 Biochemical Society 2007 C2 domain calcium phosphatidylserine polybasic cluster protein kinase C (PKC) PtdIns(4,5) P 2 PKC (protein kinase C) is a large family of phospholipid-dependent serine/threonine kinases, which is activated by many extracellular...
Articles
Biochem Soc Trans (2007) 35 (5): 1088–1091.
Published: 25 October 2007
... ). 2 Present address: Department of Biology (Area 9), University of York, PO Box 373, York YO10 5YW, U.K. 20 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium endocytosis endosome lysosome mucolipin multivesicular body The acid lumen...
Articles
Biochem Soc Trans (2007) 35 (1): 133–135.
Published: 22 January 2007
... 2006 apoptosis calcium cell differentiation cell proliferation prostate cancer transient receptor potential channel (TRP channel) PC (prostate cancer) is one of the leading threats to men's health. Its early stage depends on androgens for growth and survival, and androgen ablation...
Articles
Biochem Soc Trans (2006) 34 (6): 1356–1361.
Published: 25 October 2006
...R. Simon; Z. Xiong Intracellular calcium toxicity remains the central feature in the pathophysiology of ischaemic cell death in brain. Glutamate-gated channels have been thought to be the major sites of ischaemia-induced toxic calcium entry, but the failure of glutamate antagonists in clinical...
Articles
Articles
Biochem Soc Trans (2006) 34 (4): 468–471.
Published: 21 July 2006
... neurons using the FRET-based cAMP indicator ‘FlCRhR’. A recent study using a truncated form of the CFP-tagged PKA RII subunit with a targeting motif that directs it to the plasma membrane along with the YFP-tagged catalytic subunit illustrates higher frequency calcium-dependent cAMP oscillations...
Articles
Biochem Soc Trans (2006) 34 (4): 498–501.
Published: 21 July 2006
... To whom correspondence should be addressed (email anders.tengholm@mcb.uu.se ). 28 3 2006 © 2006 The Biochemical Society 2006 calcium cAMP fluorescein arsenical helix binder (FlAsH) glucagon-like peptide-1 insulin protein kinase A (PKA) Since cAMP is involved in many...
Articles
Biochem Soc Trans (2006) 34 (4): 515–517.
Published: 21 July 2006
..., potentiated responses may provide a novel mechanism for integrating the effects of systemic PTH and local signals like ATP [ 11 ]. calcium cAMP G-protein inositol 1,4,5-trisphosphate intracellular signalling parathyroid hormone PTH is the key regulator of plasma Ca 2+ homoeostasis and bone...
Articles
Biochem Soc Trans (2006) 34 (3): 374–376.
Published: 22 May 2006
... calcium microdomain 5′-nucleotidase raft smooth muscle Assuming that membrane rafts regulate 5′-nucleotidase activity, the effects of raft destabilization were investigated. Stabilized by cholesterol, lipid rafts are resistant to solubilization by non-ionic detergents and can therefore...
Articles
Biochem Soc Trans (2006) 34 (3): 370–373.
Published: 22 May 2006
... degradation), sterol and lipid biosynthesis and calcium sequestration. The last two, as well as apoptosis, are critically regulated by the close association of the SER with mitochondria. Studies with AMFR (autocrine motility factor receptor) have defined an SER domain whose integrity and mitochondrial...
Articles
Biochem Soc Trans (2006) 34 (2): 228–231.
Published: 20 March 2006
... states such as Alzheimer's disease, asthma, diabetes, hypertension, manic-depressive illness and heart disease. This review explores the mechanisms that are responsible for signalosome stability and how an alteration in these mechanisms can lead to the onset of cardiac disease. calcium cardiac...
Articles
Biochem Soc Trans (2003) 31 (5): 939–942.
Published: 01 October 2003
... specifically with changes in electrophysiological properties of cells and intracellular calcium regulation. 1 e-mail: stephen.c.o'neill@man.ac.uk Calcium Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003...
Articles
Biochem Soc Trans (2003) 31 (5): 912–915.
Published: 01 October 2003
...D.M.F. Cooper Calcium-sensitive adenylate cyclases provide a key regulatory device for integrating the activities of the two major signalling systems, Ca 2+ and cAMP. Recent experiments have brought us closer to understanding the molecular mechanisms whereby Ca 2+ either stimulates or inhibits...
Articles
Biochem Soc Trans (2003) 31 (5): 950–953.
Published: 01 October 2003
...H.L. Roderick; M.D. Bootman Calcium is a pleiotropic messenger controlling a diverse array of intracellular events from fertilization to cell death. One of the main mechanisms by which intracellular calcium is elevated is through Ins P 3 [Ins(1,4,5) P 3 ]-induced mobilization of calcium from its...
Articles
Biochem Soc Trans (2003) 31 (5): 960–962.
Published: 01 October 2003
... the possibility of positive feedback. 1 To whom correspondence should be addressed (e-mail ron.jacob@kcl.ac.uk ). Calcium Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003 2 April 2003 © 2003...
Articles
Biochem Soc Trans (2003) 31 (4): 828–832.
Published: 01 August 2003
... by Ca 2+ -binding proteins, including a group of proteins known as neuronal calcium sensor (NCS) proteins. The NCS family includes NCS-1, visinin-like proteins, recoverins, guanylate cyclase-activating proteins and potassium channel-interacting proteins. Some members of this family, such as recoverin...
Articles
Biochem Soc Trans (2002) 30 (4): 812–815.
Published: 01 August 2002
... proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux. 1 E-mail martin.turner@bbsrc.ac.uk 15 4 2002 © 2002 Biochemical Society 2002 calcium knockout mice lymphocyte activation BCR, B-cell...