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Keywords: calcium
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Articles
Biochem Soc Trans (2020) 48 (1): 61–70.
Published: 27 February 2020
...Aleksandra Judina; Julia Gorelik; Peter T. Wright Multiple intra-cellular signalling pathways rely on calcium and 3′–5′ cyclic adenosine monophosphate (cAMP) to act as secondary messengers. This is especially true in cardiomyocytes which act as the force-producing units of the cardiac muscle...
Articles
Biochem Soc Trans (2019) 47 (6): 1963–1969.
Published: 26 November 2019
... 8 11 2019 8 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 bioenergetics calcium complex I mitochondria reactive oxygen species Introduction Mitochondria are distinguishable from the other numerous...
Articles
Biochem Soc Trans (2016) 44 (2): 452–459.
Published: 11 April 2016
... information, we describe how the variable ER redox conditions govern Ca 2+ flux from the ER. calcium endoplasmic reticulum (ER) inositol 1 4 5-trisphosphate receptor (IP3R) mitochondria-associated membrane (MAM) redox-dependent regulation sarco/endoplasmic reticulum Ca 2+ transport ATPase (SERCA...
Articles
Biochem Soc Trans (2016) 44 (1): 202–211.
Published: 09 February 2016
...Robin Irvine Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5) P 3 as a calcium-mobilizing second messenger was first suggested and then experimentally established. At the same time the unexpected complexity of inositide metabolism began to be exposed by the discovery of Ins...
Articles
Biochem Soc Trans (2016) 44 (1): 7–12.
Published: 09 February 2016
...Maria E. Solesio; Pia A. Elustondo; Eleonora Zakharian; Evgeny V. Pavlov Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological calcium overload leads to the membrane depolarization and disruption...
Articles
Biochem Soc Trans (2016) 44 (1): 1–6.
Published: 09 February 2016
...Noelia Lander; Ciro Cordeiro; Guozhong Huang; Roberto Docampo Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H + -PPase or VP1), the vacuolar proton...
Articles
Biochem Soc Trans (2016) 44 (1): 253–259.
Published: 09 February 2016
..., inositol phosphates and polyP, speculating on the evolution of these relationships. © 2016 Authors; published by Portland Press Limited 2016 calcium evolution inositol metabolism phosphate The fine organization of a biological system is constantly challenged by the always-changing...
Articles
Biochem Soc Trans (2015) 43 (3): 349–358.
Published: 01 June 2015
...)-dependant increase in sarcoendoplasmic reticulum calcium transport ATPase (SERCA) activity [ 18 ], which increases the ER Ca 2+ concentration that then sensitizes both the RYRs and the InsP 3 Rs. In a reciprocal way, entry of Ca 2+ into the mitochondria enhances energy metabolism resulting in an increased...
Articles
Biochem Soc Trans (2015) 43 (3): 502–507.
Published: 01 June 2015
...+ binding within intracellular domains of the channel, leading to the opening of the ion pore; as described for the Ca 2+ -activated Cl − channel TMEM16A (transmembrane member 16A) [ 33 ]. In contrast, K Ca 3.1 (intermediate-conductance calcium-activated K + channel) relies upon calmodulin as a sensor...
Articles
Biochem Soc Trans (2014) 42 (5): 1302–1310.
Published: 18 September 2014
...Terri-Leigh Stephen; Swati Gupta-Agarwal; Josef T. Kittler Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca 2+ ) levels in response to synaptic activity. Astrocyte Ca 2+ elevations can trigger the release of neuroactive substances that can modulate...
Articles
Biochem Soc Trans (2014) 42 (5): 1441–1446.
Published: 18 September 2014
... -binding proteins are known targets of calmodulin (CaM), which, depending on the presence of calcium, can compete with PI(4,5)P 2 for protein interaction, translating Ca 2+ transient microdomains into variations of PI(4,5)P 2 lateral organization in time and space. The present review highlights different...
Articles
Biochem Soc Trans (2012) 40 (2): 297–309.
Published: 21 March 2012
..., but their higher affinities mean that they can complete the recovery process and can continue to pump to maintain the low resting levels of Ca 2+ at approximately 100 nM. Alzheimer's disease bipolar disorder calcium heart inositol schizophrenia Calcium (Ca 2+ ) is a highly versatile...
Articles
Biochem Soc Trans (2012) 40 (1): 153–157.
Published: 19 January 2012
... should be addressed (email patel.s@ucl.ac.uk ). 4 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium endosome lysosome membrane contact site nicotinic acid–adenine dinucleotide phosphate (NAADP) two-pore channel Changes in the concentration...
Articles
Biochem Soc Trans (2012) 40 (1): 44–50.
Published: 19 January 2012
... © 2012 Biochemical Society 2012 calcium cAMP circadian rhythm clock second messenger suprachiasmatic nucleus (SCN) 1 To whom correspondence should be addressed (email jso22@medschl.cam.ac.uk ). In attempts to reconcile genetic models with cellular data and circadian...
Articles
Biochem Soc Trans (2011) 39 (5): 1136–1141.
Published: 21 September 2011
.... Krementsova E.B. Trybus K.M. Myosin V: regulation by calcium, calmodulin, and the tail domain J. Cell Biol. 2004 164 877 886 22 Sato O. Li X.D. Ikebe M. Myosin Va becomes a low duty ratio motor in the inhibited form J. Biol. Chem. 2007 282 13228 13239 23 Wang...
Articles
Biochem Soc Trans (2010) 38 (5): 1319–1321.
Published: 24 September 2010
... adrenaline calcium Modular Control and Regulation Analysis non-invasive 31 P-NMR perfused heart systems biology Top-down or modular approaches to MCA (Metabolic Control Analysis) have been used by us and others to overcome the complexity of investigating intracellular and intra-organ regulation...
Articles
Biochem Soc Trans (2009) 37 (6): 1369–1374.
Published: 19 November 2009
... A. Neher E. Fractional contribution of calcium to the cation current through glutamate receptor channels Neuron 1993 11 133 143 48 Burnashev N. Recombinant ionotropic glutamate receptors: functional distinctions imparted by different subunits Cell. Physiol. Biochem. 1993 3 318...
Articles
Biochem Soc Trans (2009) 37 (1): 200–203.
Published: 20 January 2009
... described for its capacity to bind to the calcium-binding protein, ALG-2. Alix regulates neuronal death in ways involving interactions with ALG-2 and with proteins of the ESCRT (endosomal sorting complex required for transport). Even though all Alix interactors characterized to date are involved...
Articles
Biochem Soc Trans (2009) 37 (1): 190–194.
Published: 20 January 2009
... protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein Cell Death Differ. 1999 6 124 129 7 Vito P. Pellegrini L. Guiet C. D'Adamio L. Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2...
Articles
Biochem Soc Trans (2008) 36 (6): 1309–1312.
Published: 19 November 2008
...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...
Articles
Biochem Soc Trans (2007) 35 (5): 1088–1091.
Published: 25 October 2007
... ). 2 Present address: Department of Biology (Area 9), University of York, PO Box 373, York YO10 5YW, U.K. 20 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium endocytosis endosome lysosome mucolipin multivesicular body The luminal ionic...
Articles
Biochem Soc Trans (2007) 35 (5): 1046–1048.
Published: 25 October 2007
.... Rohacs T. Balla T. J. Cell Biol. 2006 175 377 382 20 Hoff B. Strandberg E. Ulrich A.S. Tieleman D.P. Posten C. Biophys. J. 2005 88 1818 1827 C2 domain calcium phosphatidylserine polybasic cluster protein kinase C (PKC) PtdIns(4,5) P 2...
Articles
Biochem Soc Trans (2007) 35 (1): 133–135.
Published: 22 January 2007
.... Lemonnier L. Slomianny C. Dewailly E. Bonnal J.L. Mauroy B. Skryma R. Prevarskaya N. J. Clin. Invest. 2003 111 1691 1701 8 Vanoverberghe K. Mariot P. Vanden Abeele F. Delcourt P. Parys J.B. Prevarskaya N. Cell Calcium 2003 34 75 85...
Articles
Biochem Soc Trans (2006) 34 (6): 1356–1361.
Published: 25 October 2006
...R. Simon; Z. Xiong Intracellular calcium toxicity remains the central feature in the pathophysiology of ischaemic cell death in brain. Glutamate-gated channels have been thought to be the major sites of ischaemia-induced toxic calcium entry, but the failure of glutamate antagonists in clinical...
Articles
Biochem Soc Trans (2006) 34 (4): 504–509.
Published: 21 July 2006
...-4 (PDE4) calcium intracellular targeting membrane insertion memory phosphatidic acid 1 To whom correspondence should be addressed (email M.Houslay@bio.gla.ac.uk ). 9 5 2006 © 2006 The Biochemical Society 2006 A key challenge to understanding regulation of cell...
Articles
Biochem Soc Trans (2006) 34 (4): 468–471.
Published: 21 July 2006
... to illustrate the formation of cAMP gradients [ 11 ], to estimate cAMP diffusion rate in invertebrate neurons [ 11 ], to simultaneously monitor the [cAMP] and PKA-mediated regulation of calcium channels in frog ventricular myocytes [ 12 ] and to report dynamic interactions between Ca 2+ transients and cAMP...
Articles
Biochem Soc Trans (2006) 34 (4): 498–501.
Published: 21 July 2006
... To whom correspondence should be addressed (email anders.tengholm@mcb.uu.se ). 28 3 2006 © 2006 The Biochemical Society 2006 calcium cAMP fluorescein arsenical helix binder (FlAsH) glucagon-like peptide-1 insulin protein kinase A (PKA) Since cAMP is involved in many...
Articles
Biochem Soc Trans (2006) 34 (4): 515–517.
Published: 21 July 2006
..., including Ca 2+ and cAMP, that lie downstream of G s is not resolved. 1 To whom correspondence should be addressed (email cwt1000@cam.ac.uk ). 4 5 2006 © 2006 The Biochemical Society 2006 calcium cAMP G-protein inositol 1,4,5-trisphosphate intracellular signalling parathyroid...
Articles
Biochem Soc Trans (2006) 34 (3): 374–376.
Published: 22 May 2006
... calcium microdomain 5′-nucleotidase raft smooth muscle 5′-Nucleotidase is an enzyme that is linked to the outer lipid layer of the plasma membrane via a GPI (glycosylphosphatidylinositol)–lipid anchor and is separated from the intracellular milieu by the inner layer of the lipid bilayer, while...
Articles
Biochem Soc Trans (2006) 34 (3): 370–373.
Published: 22 May 2006
... degradation), sterol and lipid biosynthesis and calcium sequestration. The last two, as well as apoptosis, are critically regulated by the close association of the SER with mitochondria. Studies with AMFR (autocrine motility factor receptor) have defined an SER domain whose integrity and mitochondrial...
Articles
Biochem Soc Trans (2006) 34 (2): 228–231.
Published: 20 March 2006
... the information responsible for the remodelling of the cardiac gene transcription programme that leads first to hypertrophy and then to congestive heart failure. calcium cardiac cell gene transcription hypertrophy inositol trisphosphate nuclear factor of activated T-cells (NFAT) Cells...
Articles
Biochem Soc Trans (2003) 31 (5): 939–942.
Published: 01 October 2003
... specifically with changes in electrophysiological properties of cells and intracellular calcium regulation. 1 e-mail: stephen.c.o'neill@man.ac.uk Calcium Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003...
Articles
Biochem Soc Trans (2003) 31 (5): 912–915.
Published: 01 October 2003
...D.M.F. Cooper Calcium-sensitive adenylate cyclases provide a key regulatory device for integrating the activities of the two major signalling systems, Ca 2+ and cAMP. Recent experiments have brought us closer to understanding the molecular mechanisms whereby Ca 2+ either stimulates or inhibits...
Articles
Biochem Soc Trans (2003) 31 (5): 950–953.
Published: 01 October 2003
...H.L. Roderick; M.D. Bootman Calcium is a pleiotropic messenger controlling a diverse array of intracellular events from fertilization to cell death. One of the main mechanisms by which intracellular calcium is elevated is through Ins P 3 [Ins(1,4,5) P 3 ]-induced mobilization of calcium from its...
Articles
Biochem Soc Trans (2003) 31 (5): 960–962.
Published: 01 October 2003
... the possibility of positive feedback. 1 To whom correspondence should be addressed (e-mail ron.jacob@kcl.ac.uk ). Calcium Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003 2 April 2003 © 2003...
Articles
Biochem Soc Trans (2003) 31 (4): 828–832.
Published: 01 August 2003
... by Ca 2+ -binding proteins, including a group of proteins known as neuronal calcium sensor (NCS) proteins. The NCS family includes NCS-1, visinin-like proteins, recoverins, guanylate cyclase-activating proteins and potassium channel-interacting proteins. Some members of this family, such as recoverin...
Articles
Biochem Soc Trans (2002) 30 (4): 812–815.
Published: 01 August 2002
... proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux. 1 E-mail martin.turner@bbsrc.ac.uk 15 4 2002 © 2002 Biochemical Society 2002 calcium knockout mice lymphocyte activation BCR, B-cell...