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Studying signal compartmentation in adult cardiomyocytes

Aleksandra Judina, Julia Gorelik, Peter T. Wright

Biochem Soc Trans (2020) 48 (1): 61–70.

DOI: https://doi.org/10.1042/BST20190247

Published: 27 February 2020

...Aleksandra Judina; Julia Gorelik; Peter T. Wright Multiple intra-cellular signalling pathways rely on calcium and 3′–5′ cyclic adenosine monophosphate (cAMP) to act as secondary messengers. This is especially true in cardiomyocytes which act as the force-producing units of the cardiac muscle...

View article titled, Studying signal compartmentation in adult cardiomyocytes

Articles

Cellular mechanisms of complex I-associated pathology

Andrey Y. Abramov, Plamena R. Angelova

Biochem Soc Trans (2019) 47 (6): 1963–1969.

DOI: https://doi.org/10.1042/BST20191042

Published: 26 November 2019

... ( p.stroh@ucl.ac.uk ) 6 11 2019 8 11 2019 8 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 bioenergetics calcium complex I mitochondria reactive oxygen species Introduction Mitochondria...

View article titled, Cellular mechanisms of complex I-associated pathology

Articles

ER-luminal thiol/selenol-mediated regulation of Ca 2+ signalling

Christian Appenzeller-Herzog, Thomas Simmen

Biochem Soc Trans (2016) 44 (2): 452–459.

DOI: https://doi.org/10.1042/BST20150233

Published: 11 April 2016

..., oxidative stress within the ER activates the UPR, which also promotes Ca 2+ leakage through the translocon [ 38 ]. calcium endoplasmic reticulum (ER) inositol 1 4 5-trisphosphate receptor (IP3R) mitochondria-associated membrane (MAM) redox-dependent regulation sarco/endoplasmic reticulum Ca 2...

View article titled, ER-luminal thiol/selenol-mediated regulation of Ca 2+ signalling

Articles

Polyphosphate and acidocalcisomes

Noelia Lander, Ciro Cordeiro, Guozhong Huang, Roberto Docampo

Biochem Soc Trans (2016) 44 (1): 1–6.

DOI: https://doi.org/10.1042/BST20150193

Published: 09 February 2016

...Noelia Lander; Ciro Cordeiro; Guozhong Huang; Roberto Docampo Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H + -PPase or VP1), the vacuolar proton...

View article titled, Polyphosphate and acidocalcisomes

Articles

Phosphate, inositol and polyphosphates

Thomas M. Livermore, Cristina Azevedo, Bernadett Kolozsvari, Miranda S.C. Wilson, Adolfo Saiardi

Biochem Soc Trans (2016) 44 (1): 253–259.

DOI: https://doi.org/10.1042/BST20150215

Published: 09 February 2016

..., inositol phosphates and polyP, speculating on the evolution of these relationships. 1 To whom correspondence should be addressed (email dmcbado@ucl.ac.uk ). 25 11 2015 © 2016 Authors; published by Portland Press Limited 2016 calcium evolution inositol metabolism phosphate...

View article titled, Phosphate, inositol and polyphosphates

Articles

Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore

Maria E. Solesio, Pia A. Elustondo, Eleonora Zakharian, Evgeny V. Pavlov

Biochem Soc Trans (2016) 44 (1): 7–12.

DOI: https://doi.org/10.1042/BST20150206

Published: 09 February 2016

...Maria E. Solesio; Pia A. Elustondo; Eleonora Zakharian; Evgeny V. Pavlov Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological calcium overload leads to the membrane depolarization and disruption...

View article titled, Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore

Articles

A tale of two inositol trisphosphates

Robin Irvine

Biochem Soc Trans (2016) 44 (1): 202–211.

DOI: https://doi.org/10.1042/BST20150205

Published: 09 February 2016

...Robin Irvine Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5) P 3 as a calcium-mobilizing second messenger was first suggested and then experimentally established. At the same time the unexpected complexity of inositide metabolism began to be exposed by the discovery of Ins...

View article titled, A tale of two inositol trisphosphates

Articles

Regulation of Pannexin-1 channel activity

Kirk A. Taylor, Joy R. Wright, Martyn P. Mahaut-Smith

Biochem Soc Trans (2015) 43 (3): 502–507.

DOI: https://doi.org/10.1042/BST20150042

Published: 01 June 2015

... to the work. 2 To whom correspondence should be addressed (email kirk.taylor@anglia.ac.uk ) . 9 2 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 Pannexin-1 Calcium Platelet Leukocyte Phosphorylation Erythrocyte ATP Caspases The connexin...

View article titled, Regulation of Pannexin-1 channel activity

Articles

Vitamin D: a custodian of cell signalling stability in health and disease

Michael J. Berridge

Biochem Soc Trans (2015) 43 (3): 349–358.

DOI: https://doi.org/10.1042/BST20140279

Published: 01 June 2015

... compilation © 2015 Biochemical Society 2015 Alzheimer's diseases antioxidants calcium cardiac disease Klotho memory phenotypic stability reactive oxygen species redox vitamin D Cells communicate with each other through external signals such as hormones, neurotransmitters and growth...

View article titled, Vitamin D: a custodian of cell signalling stability in health and disease

Articles

Role of calcium in membrane interactions by PI(4,5)P 2 -binding proteins

Marina E. Monteiro, Maria J. Sarmento, Fábio Fernandes

Biochem Soc Trans (2014) 42 (5): 1441–1446.

DOI: https://doi.org/10.1042/BST20140149

Published: 18 September 2014

... -binding proteins are known targets of calmodulin (CaM), which, depending on the presence of calcium, can compete with PI(4,5)P 2 for protein interaction, translating Ca 2+ transient microdomains into variations of PI(4,5)P 2 lateral organization in time and space. The present review highlights different...

View article titled, Role of calcium in membrane interactions by PI(4,5)P 2 -binding proteins

Articles

Mitochondrial dynamics in astrocytes

Terri-Leigh Stephen, Swati Gupta-Agarwal, Josef T. Kittler

Biochem Soc Trans (2014) 42 (5): 1302–1310.

DOI: https://doi.org/10.1042/BST20140195

Published: 18 September 2014

...Terri-Leigh Stephen; Swati Gupta-Agarwal; Josef T. Kittler Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca 2+ ) levels in response to synaptic activity. Astrocyte Ca 2+ elevations can trigger the release of neuroactive substances that can modulate...

View article titled, Mitochondrial dynamics in astrocytes

Articles

Calcium signalling remodelling and disease

Michael J. Berridge

Biochem Soc Trans (2012) 40 (2): 297–309.

DOI: https://doi.org/10.1042/BST20110766

Published: 21 March 2012

... dysregulation of Ca 2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease. © The Authors Journal compilation © 2012 Biochemical Society 2012 Alzheimer's disease bipolar disorder calcium heart inositol...

View article titled, Calcium signalling remodelling and disease

Articles

Triggering of Ca 2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?

Sandip Patel, Eugen Brailoiu

Biochem Soc Trans (2012) 40 (1): 153–157.

DOI: https://doi.org/10.1042/BST20110693

Published: 19 January 2012

..., Timothy Levine and Chi Li for useful discussion. This work was supported by the Biotechnology and Biological Sciences Research Council [grant BB/G013721/1 (to S.P.)]. References 1 Berridge M.J. Lipp P. Bootman M.D. The versatility and universality of calcium signalling Nat...

View article titled, Triggering of Ca 2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?

Articles

The essential role of cAMP/Ca 2+ signalling in mammalian circadian timekeeping

John S. O'Neill, Akhilesh B. Reddy

Biochem Soc Trans (2012) 40 (1): 44–50.

DOI: https://doi.org/10.1042/BST20110691

Published: 19 January 2012

..., phase and period. It is proposed that daily auto-amplification of second messenger activity, through paracrine neuropeptidergic coupling, is necessary and sufficient to account for the increased amplitude, accuracy and robustness of SCN timekeeping. calcium cAMP circadian rhythm clock second...

View article titled, The essential role of cAMP/Ca 2+ signalling in mammalian circadian timekeeping

Articles

Regulation of myosin 5a and myosin 7a

Verl B. Siththanandan, James R. Sellers

Biochem Soc Trans (2011) 39 (5): 1136–1141.

DOI: https://doi.org/10.1042/BST0391136

Published: 21 September 2011

... in the formation and maintenance of actin bundles such as are found in filopodia, hair cell stereocilia and enterocyte brush border microvilli. actin ATPase activity calcium myosin In general, myosins have three distinctive domains. A motor domain, usually located at the N-terminus, contains...

View article titled, Regulation of myosin 5a and myosin 7a

Articles

System analysis of the effect of various drugs on cardiac contraction energetics

Véronique Deschodt-Arsac, Guillaume Calmettes, Gilles Gouspillou, Richard Rouland, Eric Thiaudiere, Sylvain Miraux, Jean-Michel Franconi, Philippe Diolez

Biochem Soc Trans (2010) 38 (5): 1319–1321.

DOI: https://doi.org/10.1042/BST0381319

Published: 24 September 2010

... adrenaline calcium Modular Control and Regulation Analysis non-invasive 31 P-NMR perfused heart systems biology Top-down or modular approaches to MCA (Metabolic Control Analysis) have been used by us and others to overcome the complexity of investigating intracellular and intra-organ regulation...

View article titled, System analysis of the effect of various drugs on cardiac contraction energetics

Articles

Regulation of NMDA receptor Ca 2+ signalling and synaptic plasticity

C. Geoffrey Lau, Koichi Takeuchi, Alma Rodenas-Ruano, Yukihiro Takayasu, Jessica Murphy, Michael V.L. Bennett, R. Suzanne Zukin

Biochem Soc Trans (2009) 37 (6): 1369–1374.

DOI: https://doi.org/10.1042/BST0371369

Published: 19 November 2009

..., MA 02138-2020, U.S.A. 2 To whom correspondence should be addressed (email suzanne.zukin@einstein.yu.edu ). 14 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 calcium N -methyl- D -aspartate receptor (NMDAR) protein kinase signalling synaptic...

View article titled, Regulation of NMDA receptor Ca 2+ signalling and synaptic plasticity

Articles

Alix and ALG-2 make a link between endosomes and neuronal death

Anne-Laure Mahul-Mellier, Flavie Strappazzon, Christine Chatellard-Causse, Béatrice Blot, David Béal, Sakina Torch, Fiona Hemming, Anne Petiot, Jean-Marc Verna, Sandrine Fraboulet, Rémy Sadoul

Biochem Soc Trans (2009) 37 (1): 200–203.

DOI: https://doi.org/10.1042/BST0370200

Published: 20 January 2009

... described for its capacity to bind to the calcium-binding protein, ALG-2. Alix regulates neuronal death in ways involving interactions with ALG-2 and with proteins of the ESCRT (endosomal sorting complex required for transport). Even though all Alix interactors characterized to date are involved...

View article titled, Alix and ALG-2 make a link between endosomes and neuronal death

Articles

The mechanism of Ca 2+ -dependent recognition of Alix by ALG-2: insights from X-ray crystal structures

Hironori Suzuki, Masato Kawasaki, Tatsutoshi Inuzuka, Mayumi Okumura, Takeshi Kakiuchi, Hideki Shibata, Soichi Wakatsuki, Masatoshi Maki

Biochem Soc Trans (2009) 37 (1): 190–194.

DOI: https://doi.org/10.1042/BST0370190

Published: 20 January 2009

... protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein Cell Death Differ. 1999 6 124 129 7 Vito P. Pellegrini L. Guiet C. D'Adamio L. Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2...

View article titled, The mechanism of Ca 2+ -dependent recognition of Alix by ALG-2: insights from X-ray crystal structures

Articles

Iron and calcium in the central nervous system: a close relationship in health and sickness

Ilaria Pelizzoni, Romina Macco, Daniele Zacchetti, Fabio Grohovaz, Franca Codazzi

Biochem Soc Trans (2008) 36 (6): 1309–1312.

DOI: https://doi.org/10.1042/BST0361309

Published: 19 November 2008

...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...

View article titled, Iron and calcium in the central nervous system: a close relationship in health and sickness

Articles

The C2 domains of classical/conventional PKCs are specific PtdIns(4,5) P 2 -sensing domains

S. Corbalán-García, M. Guerrero-Valero, C. Marín-Vicente, J.C. Gómez-Fernández

Biochem Soc Trans (2007) 35 (5): 1046–1048.

DOI: https://doi.org/10.1042/BST0351046

Published: 25 October 2007

... The Authors Journal compilation © 2007 Biochemical Society 2007 C2 domain calcium phosphatidylserine polybasic cluster protein kinase C (PKC) PtdIns(4,5) P 2 PKC (protein kinase C) is a large family of phospholipid-dependent serine/threonine kinases, which is activated by many extracellular...

View article titled, The C2 domains of classical/conventional PKCs are specific PtdIns(4,5) P 2 -sensing domains

Articles

The role of calcium and other ions in sorting and delivery in the late endocytic pathway

J.P. Luzio, N.A. Bright, P.R. Pryor

Biochem Soc Trans (2007) 35 (5): 1088–1091.

DOI: https://doi.org/10.1042/BST0351088

Published: 25 October 2007

... ). 2 Present address: Department of Biology (Area 9), University of York, PO Box 373, York YO10 5YW, U.K. 20 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium endocytosis endosome lysosome mucolipin multivesicular body The luminal ionic...

View article titled, The role of calcium and other ions in sorting and delivery in the late endocytic pathway

Articles

Differential role of TRP channels in prostate cancer

N. Prevarskaya, M. Flourakis, G. Bidaux, S. Thebault, R. Skryma

Biochem Soc Trans (2007) 35 (1): 133–135.

DOI: https://doi.org/10.1042/BST0350133

Published: 22 January 2007

... the conditions for abnormal tissue growth, which ultimately can turn into uncontrolled expansion and invasion characteristics of cancer. The role of calcium (Ca 2+ ) in the overall cancer-related cell signalling pathways is uncontested. Alterations in Ca 2+ homoeostasis have been described to increase...

View article titled, Differential role of TRP channels in prostate cancer

Articles

Acidotoxicity in brain ischaemia

R. Simon, Z. Xiong

Biochem Soc Trans (2006) 34 (6): 1356–1361.

DOI: https://doi.org/10.1042/BST0341356

Published: 25 October 2006

...R. Simon; Z. Xiong Intracellular calcium toxicity remains the central feature in the pathophysiology of ischaemic cell death in brain. Glutamate-gated channels have been thought to be the major sites of ischaemia-induced toxic calcium entry, but the failure of glutamate antagonists in clinical...

View article titled, Acidotoxicity in brain ischaemia

Articles

cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling

E. Huston, T.M. Houslay, G.S. Baillie, M.D. Houslay

Biochem Soc Trans (2006) 34 (4): 504–509.

DOI: https://doi.org/10.1042/BST0340504

Published: 21 July 2006

...-4 (PDE4) calcium intracellular targeting membrane insertion memory phosphatidic acid 1 To whom correspondence should be addressed (email M.Houslay@bio.gla.ac.uk ). 9 5 2006 © 2006 The Biochemical Society 2006 A key challenge to understanding regulation of cell...

View article titled, cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling

Articles

Use of single-cell imaging techniques to assess the regulation of cAMP dynamics

D. Willoughby, D.M.F. Cooper

Biochem Soc Trans (2006) 34 (4): 468–471.

DOI: https://doi.org/10.1042/BST0340468

Published: 21 July 2006

... dmfc2@cam.ac.uk ). 13 3 2006 © 2006 The Biochemical Society 2006 adenylate cyclase (AC) calcium cAMP cyclic nucleotide-gated channel (CNGC) exchange protein directly activated by cAMP (Epac) fluorescence resonance energy transfer (FRET) phosphodiesterase (PDE) Numerous...

View article titled, Use of single-cell imaging techniques to assess the regulation of cAMP dynamics

Articles

cAMP oscillations restrict protein kinase A redistribution in insulin-secreting cells

O. Dyachok, J. Sågetorp, Y. Isakov, A. Tengholm

Biochem Soc Trans (2006) 34 (4): 498–501.

DOI: https://doi.org/10.1042/BST0340498

Published: 21 July 2006

... To whom correspondence should be addressed (email anders.tengholm@mcb.uu.se ). 28 3 2006 © 2006 The Biochemical Society 2006 calcium cAMP fluorescein arsenical helix binder (FlAsH) glucagon-like peptide-1 insulin protein kinase A (PKA) Since cAMP is involved in many...

View article titled, cAMP oscillations restrict protein kinase A redistribution in insulin-secreting cells

Articles

Signalling from parathyroid hormone

S.C. Tovey, S.G. Dedos, C.W. Taylor

Biochem Soc Trans (2006) 34 (4): 515–517.

DOI: https://doi.org/10.1042/BST0340515

Published: 21 July 2006

... the variety of common diseases, such as hyperparathyroidism, associated with defective control of PTH release, and the demonstration that pulsatile delivery of PTH is an effective treatment for osteoporosis [ 1 , 2 ]. 4 5 2006 © 2006 The Biochemical Society 2006 calcium cAMP G-protein...

View article titled, Signalling from parathyroid hormone

Articles

Regulation of ecto-5′-nucleotidase activity via Ca 2+ -dependent, annexin 2-mediated membrane rearrangement?

E.B. Babiychuk, A. Draeger

Biochem Soc Trans (2006) 34 (3): 374–376.

DOI: https://doi.org/10.1042/BST0340374

Published: 22 May 2006

... calcium microdomain 5′-nucleotidase raft smooth muscle GPI glycosylphosphatidylinositol MCD methyl-β-cyclodextrin PE phosphatidylethanolamine References 1 Harder T. Simons K. Curr. Opin. Cell Biol. 1997 9 534 542 2 Brown D.A. London E...

View article titled, Regulation of ecto-5′-nucleotidase activity via Ca 2+ -dependent, annexin 2-mediated membrane rearrangement?

Articles

Interaction of the smooth endoplasmic reticulum and mitochondria

J.G. Goetz, I.R. Nabi

Biochem Soc Trans (2006) 34 (3): 370–373.

DOI: https://doi.org/10.1042/BST0340370

Published: 22 May 2006

... degradation), sterol and lipid biosynthesis and calcium sequestration. The last two, as well as apoptosis, are critically regulated by the close association of the SER with mitochondria. Studies with AMFR (autocrine motility factor receptor) have defined an SER domain whose integrity and mitochondrial...

View article titled, Interaction of the smooth endoplasmic reticulum and mitochondria

Articles

Remodelling Ca 2+ signalling systems and cardiac hypertrophy

M.J. Berridge

Biochem Soc Trans (2006) 34 (2): 228–231.

DOI: https://doi.org/10.1042/BST0340228

Published: 20 March 2006

... the information responsible for the remodelling of the cardiac gene transcription programme that leads first to hypertrophy and then to congestive heart failure. 1 email michael.berridge@bbsrc.ac.uk 14 9 2005 © 2006 The Biochemical Society 2006 calcium cardiac cell gene transcription...

View article titled, Remodelling Ca 2+ signalling systems and cardiac hypertrophy

Articles

Anti-arrhythmic actions of polyunsaturated fatty acids in cardiac muscle exerted via the sarcoplasmic reticulum

S. O'Neill

Biochem Soc Trans (2003) 31 (5): 939–942.

DOI: https://doi.org/10.1042/bst0310939

Published: 01 October 2003

... specifically with changes in electrophysiological properties of cells and intracellular calcium regulation. 1 e-mail: stephen.c.o'neill@man.ac.uk Calcium Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003...

View article titled, Anti-arrhythmic actions of polyunsaturated fatty acids in cardiac muscle exerted via the sarcoplasmic reticulum

Articles

Molecular and cellular requirements for the regulation of adenylate cyclases by calcium

D.M.F. Cooper

Biochem Soc Trans (2003) 31 (5): 912–915.

DOI: https://doi.org/10.1042/bst0310912

Published: 01 October 2003

...D.M.F. Cooper Calcium-sensitive adenylate cyclases provide a key regulatory device for integrating the activities of the two major signalling systems, Ca 2+ and cAMP. Recent experiments have brought us closer to understanding the molecular mechanisms whereby Ca 2+ either stimulates or inhibits...

View article titled, Molecular and cellular requirements for the regulation of adenylate cyclases by calcium

Articles

Bi-directional signalling from the InsP3 receptor: regulation by calcium and accessory factors

H.L. Roderick, M.D. Bootman

Biochem Soc Trans (2003) 31 (5): 950–953.

DOI: https://doi.org/10.1042/bst0310950

Published: 01 October 2003

...H.L. Roderick; M.D. Bootman Calcium is a pleiotropic messenger controlling a diverse array of intracellular events from fertilization to cell death. One of the main mechanisms by which intracellular calcium is elevated is through Ins P 3 [Ins(1,4,5) P 3 ]-induced mobilization of calcium from its...

View article titled, Bi-directional signalling from the InsP3 receptor: regulation by calcium and accessory factors

Articles

Agonist-induced calcium and oxidative stress responses in endothelial cells

Jenny A. Wilkinson, Ron Jacob

Biochem Soc Trans (2003) 31 (5): 960–962.

DOI: https://doi.org/10.1042/bst0310960

Published: 01 October 2003

... the possibility of positive feedback. 1 To whom correspondence should be addressed (e-mail ron.jacob@kcl.ac.uk ). Calcium Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003 2 April 2003 © 2003...

View article titled, Agonist-induced calcium and oxidative stress responses in endothelial cells

Articles

Neuronal calcium sensor-1: a multifunctional regulator of secretion

S. Hilfiker

Biochem Soc Trans (2003) 31 (4): 828–832.

DOI: https://doi.org/10.1042/bst0310828

Published: 01 August 2003

... by Ca 2+ -binding proteins, including a group of proteins known as neuronal calcium sensor (NCS) proteins. The NCS family includes NCS-1, visinin-like proteins, recoverins, guanylate cyclase-activating proteins and potassium channel-interacting proteins. Some members of this family, such as recoverin...

View article titled, Neuronal calcium sensor-1: a multifunctional regulator of secretion

Articles

B-cell development and antigen receptor signalling

M. Turner

Biochem Soc Trans (2002) 30 (4): 812–815.

DOI: https://doi.org/10.1042/bst0300812

Published: 01 August 2002

... proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux. 1 E-mail martin.turner@bbsrc.ac.uk 15 4 2002 © 2002 Biochemical Society 2002 calcium knockout mice lymphocyte activation BCR, B-cell...

View article titled, B-cell development and antigen receptor signalling

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