... of the Biochemical Society 2019 budding ESCRT membrane fission VPS4 Endosomal sorting complex required for transport-III (ESCRT-III) is an evolutionarily conserved protein machinery that mediates membrane-remodeling including scission in a variety of cellular contexts in eukaryotes and archaea [ 1...

... worldwide, and have a significant financial impact on society. Assembly and budding of new viral particles are a complex and multi-step process involving several host and viral factors. Influenza viruses use lipid raft domains in the apical plasma membrane of polarized epithelial cells as sites of budding...

... from infected cells. 1 To whom correspondence should be addressed (email mveit@zedat.fu-berlin.de ). 20 8 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 budding haemagglutinin (HA) influenza virus M2 membrane fusion virus taxonomy HA...

..., viral components including the transmembrane glycoproteins, structural proteins and the viral genome must be targeted to the site of viral budding, where they assemble and are incorporated into a newly formed virion that gains a lipid envelope from a cellular membrane. Recent work has revealed...

..., budding of some enveloped viruses and cytokinesis. ESCRT-III is composed of 11 members in humans, which, except for one, correspond to the six ESCRT-III-like proteins in yeast. At least CHMP (charged multivesicular body protein) 2A and CHMP3 assemble into helical tubular structures that provide a platform...