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Keywords: breast cancer
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Articles
Biochem Soc Trans (2020) 48 (4): 1599–1607.
Published: 14 July 2020
... ]. In the context of cancer, ablation of FIP200 in the MMTV-PyMT (mouse mammary tumor virus- polyoma middle T antigen) mouse model of luminal breast cancer delayed tumorigenesis, growth and metastasis [ 41 ]. This study demonstrated a pro-tumorigenic role for autophagy, in an immune-competent model of cancer. Other...
Articles
Biochem Soc Trans (2019) 47 (1): 109–117.
Published: 09 January 2019
...Charlotte Roelofs; Frédéric Hollande; Richard Redvers; Robin L. Anderson; Delphine Merino Until recently, established cancer cell lines have been used extensively in breast cancer research, due largely to the difficulties associated with the manipulation and long-term maintenance in culture...
Articles
Biochem Soc Trans (2018) 46 (4): 779–788.
Published: 14 June 2018
...Joy M. Burchell; Richard Beatson; Rosalind Graham; Joyce Taylor-Papadimitriou; Virginia Tajadura-Ortega Changes in mucin-type O-linked glycosylation are seen in over 90% of breast cancers where increased sialylation is often observed and a change from branched glycans to linear glycans is often...
Articles
Biochem Soc Trans (2017) 45 (1): 223–228.
Published: 15 February 2017
... to eliminate the primary tumor, prevent reoccurrence and metastasis, and enhance the treatment of breast cancer. Figure 1. The diagram shows the cycle of events during which epithelial cells are transformed into mesenchymal cells and vice versa . The different stages during EMT and the reverse process...
Articles
Biochem Soc Trans (2016) 44 (4): 979–986.
Published: 15 August 2016
... the same issue of promiscuous binding as the parent compound [ 56 ]. 1 To whom correspondence should be addressed (email james.brown@nuigalway.ie ). acetyltransferase anacardic acid bisubstrate breast cancer curcumin garcinol HAT histone HTATIP inhibitor KAT Kat5 Lys-CoA lysine...
Articles
Biochem Soc Trans (2016) 44 (1): 240–252.
Published: 09 February 2016
... and testes size [ 33 ]. Isoform-specific roles in cancer are also emerging. Akt1 inhibits but Akt2 promotes breast cancer metastasis in murine models [ 34 , 35 ]; and Akt1 enhances whereas Akt3 inhibits the growth of vascular tumours [ 36 ]. These isoform-specific signalling cascades are complex...
Articles
Biochem Soc Trans (2014) 42 (6): 1519–1523.
Published: 17 November 2014
..., could also confer protection against cell death. Furthermore, its localization in cell and nuclear membranes in breast cancer biopsies of neoadjuvant-treated breast cancer patients was an indicator for poor survival and a predictor for the effectiveness of treatment. PKCη is also a novel biomarker...
Articles
Biochem Soc Trans (2014) 42 (6): 1498–1505.
Published: 17 November 2014
... A. Ellis; Borivoj Vojnovic; Anthony C.C. Coolen; Tony Ng Breast cancer heterogeneity demands that prognostic models must be biologically driven and recent clinical evidence indicates that future prognostic signatures need evaluation in the context of early compared with late metastatic risk prediction...
Articles
Biochem Soc Trans (2014) 42 (5): 1349–1355.
Published: 18 September 2014
... be addressed (email atoker@bidmc.harvard.edu ). 30 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Akt breast cancer cancer phosphoinositide 3-kinase (PI3K) phosphorylation signalling substrate The serine/threonine protein kinase Akt, also known...
Articles
Biochem Soc Trans (2014) 42 (4): 733–741.
Published: 11 August 2014
... are in clinical trials. Unfortunately, current therapies for advanced cancers that target PI3K often lead to the development of resistance and relapse of the disease. It is therefore important to establish the molecular mechanisms of resistance to PI3K-targeted therapy. With the focus on breast cancer...
Articles
Biochem Soc Trans (2014) 42 (4): 1017–1023.
Published: 11 August 2014
... review focuses on the different known mechanisms partaking in said anti-tumour effects, with particular emphasis on breast cancer. Their structure and reactivity allows flavonoids to work as antioxidant agents and phyto-oestrogens, modulating oestrogen signalling and metabolism to induce an overall anti...
Articles
Biochem Soc Trans (2014) 42 (4): 822–830.
Published: 11 August 2014
...Helen Creedon; Adam Byron; Joanna Main; Larry Hayward; Teresa Klinowska; Valerie G. Brunton HER2 (human epidermal growth factor receptor 2)-targeted therapy in breast cancer is one of the earliest and arguably most successful examples of the modern class of targeted drugs. Initially identified...
Articles
Biochem Soc Trans (2012) 40 (4): 752–758.
Published: 20 July 2012
... (oestrogen receptors). ER status is important for the development, progression and treatment of breast cancer. miRNAs (microRNAs) are small non-coding RNAs that bind the 3′-UTR (untranslated region) of target mRNAs to reduce their stability and/or translation. miRNAs participate in oestrogen signalling...
Articles
Biochem Soc Trans (2008) 36 (6): 1247–1251.
Published: 19 November 2008
... states. In the present paper, I describe a mechanism for the role of ZIP7 in the progression of breast cancer, identifying it as a new target in breast cancer. Furthermore, I document a link between another zinc transporter, LIV-1, and breast cancer metastasis, identifying it as a potential new...
Articles
Biochem Soc Trans (2007) 35 (2): 405–409.
Published: 20 March 2007
... The Biochemical Society 2007 1 To whom correspondence should be addressed (email stina.oredsson@cob.lu.se ). apoptosis breast cancer cell cycle neuroblastoma oxidative stress polyamine analogue Complex networks of interacting molecules govern cell proliferation, cell differentiation and cell...
Articles
Biochem Soc Trans (2007) 35 (1): 18–22.
Published: 22 January 2007
...M.J. Bissell The interplay between genes and environment is complex, particularly when it comes to cancer. Studies on breast cancer cells have shown that environmental influences dominate over genotype in their effect on phenotype, and can cause cancerous cells to revert to a non-malignant...
Articles
Biochem Soc Trans (2001) 29 (2): 205–209.
Published: 01 May 2001
...H. Wiseman; R. Duffy Steroids and related compounds are important in disease development and prevention, via steroid receptor-mediated and receptor-independent mechanisms. Interaction of endogenous oestrogens with the oestrogen receptor has unfortunate mitogenic effects in breast cancer. However...
Articles
Biochem Soc Trans (2001) 29 (2): 209–216.
Published: 01 May 2001
...C. J. Kirk; R. M. Harris; D. M. Wood; R. H. Waring; P. J. Hughes Phytoestrogens are natural constituents of our diets that have been suggested to protect against hormone-dependent breast cancer. Some of the diverse effects of these compounds may be attributed to ligand-dependent differences...