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Keywords: brain aging
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 101–105.
Published: 29 January 2013
... that declined levels of circulating IGF-1 and impairments of IIS in the brain contribute to the age-dependent cognitive decline and Alzheimer's disease and that insulin resistance observed in diabetes constitutes a risk factor for Alzheimer's disease [ 8 ]. brain aging c-Jun N-terminal kinase (JNK...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1041–1044.
Published: 26 October 2005
... and learning and memory, and disturbances in insulin signalling pathways in the periphery and in the brain have recently been implicated in Alzheimer's disease and brain aging. Insulin also regulates the metabolism of β-amyloid and tau, the building blocks of amyloid plaques and neurofibrillary tangles...
