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Keywords: bipolar disorder
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Articles
Biochem Soc Trans (2012) 40 (2): 297–309.
Published: 21 March 2012
... dysregulation of Ca 2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease. Ca 2+ pumps and exchangers are responsible for pumping Ca 2+ out of the cell or back into the ER. These pumps and exchangers operate...
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Biochem Soc Trans (2009) 37 (5): 1133–1138.
Published: 21 September 2009
...W. Timothy O'Brien; Peter S. Klein Lithium is widely used to treat bipolar disorder, but its mechanism of action in this disorder is unknown. Lithium directly inhibits GSK3 (glycogen synthase kinase 3), a critical regulator of multiple signal transduction pathways. Inhibition of GSK3 provides...
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Biochem Soc Trans (2009) 37 (5): 1096–1098.
Published: 21 September 2009
...Marcella Bellani; Ping-Hong Yeh; Michele Tansella; Matteo Balestrieri; Jair C. Soares; Paolo Brambilla Although the pathogenesis of bipolar disorder is still not completely understood, there is evidence from imaging studies that abnormalities in inter-hemispheric communication may play a major role...
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Biochem Soc Trans (2009) 37 (5): 1099–1103.
Published: 21 September 2009
... of which may be associated with bipolar disorder. Cells normally derive inositol from three sources: (i) de novo biosynthesis from glucose 6-phosphate by MIPS (1- D - myo -inositol-phosphate synthase) [ 9 ]; (ii) dephosphorylation of inositol phosphates derived from the breakdown of inositol-containing...
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Biochem Soc Trans (2009) 37 (5): 1126–1132.
Published: 21 September 2009
...Nicole Terbach; Robin S.B. Williams The anticonvulsant properties of VPA (valproic acid), a branched short-chain fatty acid, were serendipitously discovered in 1963. Since then, therapeutic roles of VPA have increased to include bipolar disorder and migraine prophylaxis, and have more recently been...
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Biochem Soc Trans (2009) 37 (5): 1110–1114.
Published: 21 September 2009
...-depletion mechanism. This has implications for the cellular mechanisms controlling phosphoinositide signalling, and offers insight into the genetics underlying risk of bipolar mood disorder. bipolar disorder chemotaxis Dictyostelium inositol depletion neuronal cell biology phosphatidylinositol...
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Biochem Soc Trans (2009) 37 (5): 1139–1143.
Published: 21 September 2009
... complex. Furthermore, this may also suggest that lithium is most effective when substrate levels are high. BD (bipolar disorder) or manic depression is a severe and common psychiatric illness that is often treated with mood-stabilizing drugs. Several molecular targets and signalling pathways have been...
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Biochem Soc Trans (2009) 37 (5): 1077–1079.
Published: 21 September 2009
...Robin S.B. Williams BD (bipolar disorder) is a devastating condition, giving rise to debilitating mood swings and a greatly increased likelihood of suicide. Research into the origins, progression and treatment of BD has been slow, primarily due to lack of suitable model systems for BD research...
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Biochem Soc Trans (2009) 37 (5): 1121–1125.
Published: 21 September 2009
... Biochemical Society 2009 bipolar disorder glycogen synthase kinase 3β (GSK3β) inositol monophosphatase (IMPase) knockout mouse lithium sodium– myo -inositol transporter (SMIT) The phosphatidylinositol cycle is a key intracellular second messenger system in brain as well as in numerous other...
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Biochem Soc Trans (2009) 37 (5): 1115–1120.
Published: 21 September 2009
...-stabilizing effects of VPA and LiCl in bipolar disorder. 1 To whom correspondence should be addressed (email M.Schweizer@hw.ac.uk ). 29 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 This work was supported by the Eda Lady Jardine Trust (S.V...