... mechanisms. Among these, oxidative enzymes play an outstanding role during the biosynthesis and degradation of Pns. They are to a high extent responsible for the structural diversity of Pn secondary metabolites and for the break-down of both man-made and biogenic Pns. Here, we review our current...

...: Kristina Haslinger ( k.haslinger@rug.nl ) © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . antibiotics biosynthesis drug...

..., during the biosynthesis of this cofactor. LarB uses a novel carboxylation mechanism involving the transient formation of a cysteinyl-pyridinium adduct. Depending on the source of the enzyme, LarEs either catalyze a sacrificial sulfur transfer from a cysteinyl side chain resulting in the formation...

... described for some of the steps. The innate immune system depletes cellular tryptophan in response to infection in order to inhibit microbial growth, and this effect is likely to be important for the efficacy of tryptophan biosynthesis inhibitors as new antibiotics. Allosteric inhibitors of both the first...

... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biosynthesis glycosylation promiscuity The biosynthesis of several physiologically important small molecules and oligosaccharides...

.... Diversity is introduced through extensive post-translational modification by enzymes encoded in the gene cluster. For example bottromycin A 2 biosynthesis includes C-methylation, thiazole formation and macrolactamidination ( Figure 1 ) [ 17 , 18 ]. In the four natural product families described...

...Wessel J.A. Moolman; Marianne de Villiers; Erick Strauss The biosynthesis and utilization of CoA (coenzyme A), the ubiquitous and essential acyl carrier in all organisms, have long been regarded as excellent targets for the development of new antimicrobial drugs. Moreover, bioinformatics...

... biosynthesis cell wall drug target Mycobacterium tuberculosis mycolic acid LU assembly is dependent on the transfer of GlcNAc-1-phosphate from UDP-GlcNAc to the lipid carrier decaprenyl monophosphate catalysed by rfe [ 17 ] ( Figure 1 ). The L -rhamnosyl component is provided by a sugar donor...

...E. Glawischnig The biosynthesis of camalexin, the main phytoalexin of the model plant Arabidopsis thaliana , involves at least two CYP (cytochrome P450) steps. It is synthesized from tryptophan via indole-3-acetaldoxime in a reaction catalysed by CYP79B2 and CYP79B3. Based on the pad3 mutant...

... of tetrapyrroles in plants. © 2005 The Biochemical Society 2005 biosynthesis chlorophyll haem plant tetrapyrrole protoporphyrin IX regulation Tetrapyrroles are essential molecules in living organisms and perform a multitude of functions throughout development. The most abundant tetrapyrrole...

...D. Heldt; A.D. Lawrence; M. Lindenmeyer; E. Deery; P. Heathcote; S.E. Rigby; M.J. Warren The aerobic biosynthetic pathway for vitamin B 12 (cobalamin) biosynthesis is reviewed. Particular attention is focused on the ring contraction process, whereby an integral carbon atom of the tetrapyrrole...

... centred on the occurrence and function of siderophores in the various bacterial and fungal genera. 1 E-mail Winkelmann@uni-tuebingen.de 18 3 2002 © 2002 Biochemical Society 2002 biosynthesis ecology stereochemistry Biometals 2002: Third International Biometals...