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Keywords: biosynthesis
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Biochem Soc Trans (2023) 51 (2): 487–499.
Published: 09 March 2023
... mechanisms. Among these, oxidative enzymes play an outstanding role during the biosynthesis and degradation of Pns. They are to a high extent responsible for the structural diversity of Pn secondary metabolites and for the break-down of both man-made and biogenic Pns. Here, we review our current...
Biochem Soc Trans (2022) 50 (4): 1187–1196.
Published: 12 August 2022
..., during the biosynthesis of this cofactor. LarB uses a novel carboxylation mechanism involving the transient formation of a cysteinyl-pyridinium adduct. Depending on the source of the enzyme, LarEs either catalyze a sacrificial sulfur transfer from a cysteinyl side chain resulting in the formation...
Biochem Soc Trans (2020) 48 (5): 2029–2037.
Published: 11 September 2020
... described for some of the steps. The innate immune system depletes cellular tryptophan in response to infection in order to inhibit microbial growth, and this effect is likely to be important for the efficacy of tryptophan biosynthesis inhibitors as new antibiotics. Allosteric inhibitors of both the first...
Biochem Soc Trans (2020) 48 (3): 891–900.
Published: 15 June 2020
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biosynthesis glycosylation promiscuity The biosynthesis of several physiologically important small molecules and oligosaccharides...
Biochem Soc Trans (2016) 44 (3): 738–744.
Published: 09 June 2016
.... Diversity is introduced through extensive post-translational modification by enzymes encoded in the gene cluster. For example bottromycin A 2 biosynthesis includes C-methylation, thiazole formation and macrolactamidination ( Figure 1 ) [ 17 , 18 ]. In the four natural product families described...
Biochem Soc Trans (2008) 36 (4): 555–565.
Published: 22 July 2008
... biosynthesis cell wall drug target Mycobacterium tuberculosis mycolic acid LU assembly is dependent on the transfer of GlcNAc-1-phosphate from UDP-GlcNAc to the lipid carrier decaprenyl monophosphate catalysed by rfe [ 17 ] ( Figure 1 ). The L -rhamnosyl component is provided by a sugar donor...
Biochem Soc Trans (2006) 34 (6): 1206–1208.
Published: 25 October 2006
...E. Glawischnig The biosynthesis of camalexin, the main phytoalexin of the model plant Arabidopsis thaliana , involves at least two CYP (cytochrome P450) steps. It is synthesized from tryptophan via indole-3-acetaldoxime in a reaction catalysed by CYP79B2 and CYP79B3. Based on the pad3 mutant...
Biochem Soc Trans (2005) 33 (4): 737–742.
Published: 01 August 2005
... of tetrapyrroles in plants. © 2005 The Biochemical Society 2005 biosynthesis chlorophyll haem plant tetrapyrrole protoporphyrin IX regulation Tetrapyrroles are essential molecules in living organisms and perform a multitude of functions throughout development. The most abundant tetrapyrrole...
Biochem Soc Trans (2005) 33 (4): 815–819.
Published: 01 August 2005
...D. Heldt; A.D. Lawrence; M. Lindenmeyer; E. Deery; P. Heathcote; S.E. Rigby; M.J. Warren The aerobic biosynthetic pathway for vitamin B 12 (cobalamin) biosynthesis is reviewed. Particular attention is focused on the ring contraction process, whereby an integral carbon atom of the tetrapyrrole...
Biochem Soc Trans (2002) 30 (4): 691–696.
Published: 01 August 2002
... centred on the occurrence and function of siderophores in the various bacterial and fungal genera. 1 E-mail Winkelmann@uni-tuebingen.de 18 3 2002 © 2002 Biochemical Society 2002 biosynthesis ecology stereochemistry Biometals 2002: Third International Biometals...