..., incorporating the effects of the joint activity of several enhancer elements is difficult. In addition, the calculation of noise outside a strict thermodynamic framework is difficult and highly parameter specific. biological models biophysics gene expression and regulation The situation is further...

... BY) . Open access for this article was enabled by the participation of Karolinska Institute in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society. biophysics confocal microscopy lattice light sheet microscopy single molecule localization microscopy super...

.... Most membrane proteins are insoluble in aqueous solvent and embedded in the plasma membrane lipid bilayer, which significantly complicates biophysical studies. Poly(styrene-co-maleic acid) (SMA) and other polymer derivatives are increasingly common solubilisation agents, used to isolate membrane...

... to further biophysical methods and to generalize it for binary molecular interactions. biophysics drug discovery molecular interactions NMR screening validation The aim of this mini-review is to introduce the validation cross as a conceptual tool for the validation of molecular interactions...

... and non-molecular factors. biophysics lipid-binding domains lipids membranes microfilaments structural biology Lipid membranes determine the shape of the cell surface and organelles. The lipid membrane is a bilayer consisting of phospholipids, sphingolipids, and cholesterol in various...

... compilation © 2014 Biochemical Society 2014 biophysics energy landscape FoldIt protein folding Rosetta@home structure determination I was reminded by the citation for the Centenary Award of how much my research group's interests have changed since I started at the University of Washington...

...@warwick.ac.uk ). 20 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 biophysics eukaryotic ribosome Förster resonance energy transfer (FRET) translation initiation Quantitative fluorescence techniques complement structural analysis to provide a deeper...

...-stimulating proteins of p53 (ASPP) biophysics natively unfolded protein p53-mediated apoptosis proline-rich domain protein–protein interaction The tumour suppressor protein p53 is at the centre of a complex protein network, which provides one of the major anticancer defence mechanisms used...