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Biochem Soc Trans (2022) 50 (5): 1365–1376.
Published: 16 September 2022
..., incorporating the effects of the joint activity of several enhancer elements is difficult. In addition, the calculation of noise outside a strict thermodynamic framework is difficult and highly parameter specific. biological models biophysics gene expression and regulation The situation is further...
Biochem Soc Trans (2022) 50 (2): 853–866.
Published: 28 March 2022
... BY) . Open access for this article was enabled by the participation of Karolinska Institute in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society. biophysics confocal microscopy lattice light sheet microscopy single molecule localization microscopy super...
Biochem Soc Trans (2021) 49 (5): 2037–2050.
Published: 13 October 2021
.... Most membrane proteins are insoluble in aqueous solvent and embedded in the plasma membrane lipid bilayer, which significantly complicates biophysical studies. Poly(styrene-co-maleic acid) (SMA) and other polymer derivatives are increasingly common solubilisation agents, used to isolate membrane...
Biochem Soc Trans (2019) 47 (1): 63–76.
Published: 21 December 2018
... to further biophysical methods and to generalize it for binary molecular interactions. biophysics drug discovery molecular interactions NMR screening validation The aim of this mini-review is to introduce the validation cross as a conceptual tool for the validation of molecular interactions...
Biochem Soc Trans (2018) 46 (2): 379–389.
Published: 14 March 2018
... and non-molecular factors. biophysics lipid-binding domains lipids membranes microfilaments structural biology Lipid membranes determine the shape of the cell surface and organelles. The lipid membrane is a bilayer consisting of phospholipids, sphingolipids, and cholesterol in various...
Biochem Soc Trans (2014) 42 (2): 225–229.
Published: 20 March 2014
... compilation © 2014 Biochemical Society 2014 biophysics energy landscape FoldIt protein folding Rosetta@home structure determination I was reminded by the citation for the Centenary Award of how much my research group's interests have changed since I started at the University of Washington...
Biochem Soc Trans (2010) 38 (6): 1587–1592.
Published: 24 November 2010
...@warwick.ac.uk ). 20 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 biophysics eukaryotic ribosome Förster resonance energy transfer (FRET) translation initiation Quantitative fluorescence techniques complement structural analysis to provide a deeper...
Biochem Soc Trans (2007) 35 (5): 966–969.
Published: 25 October 2007
...-stimulating proteins of p53 (ASPP) biophysics natively unfolded protein p53-mediated apoptosis proline-rich domain protein–protein interaction The tumour suppressor protein p53 is at the centre of a complex protein network, which provides one of the major anticancer defence mechanisms used...