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Keywords: biomolecular condensates
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Biochem Soc Trans (2024) 52 (3): 961–972.
Published: 30 May 2024
..., and their capacity to form biomolecular condensates (BMCs) is key to their function, but also a vulnerability that can lead to misregulation and disease. Matrin-3 (MATR3) is an intrinsically disordered RBP implicated both genetically and pathologically in ALS/FTD, though it is relatively understudied as compared...
Biochem Soc Trans (2021) 49 (6): 2591–2600.
Published: 25 November 2021
... compartmentalization, revealing that, in addition to membrane-bound organelles, phase-separated cytoplasmic microenvironments — termed biomolecular condensates — are compositionally and functionally distinct from the surrounding cytoplasm, without the need for a lipid membrane. The coupling of phase separation and RNA...
Biochem Soc Trans (2020) 48 (6): 2591–2602.
Published: 10 December 2020
...Pinaki Swain; Stephanie C. Weber Biomolecular condensates comprise a diverse and ubiquitous class of membraneless organelles. Condensate assembly is often described by liquid–liquid phase separation. While this process explains many key features, it cannot account for the compositional...