... clinical presentation is rather similar in sepsis of different etiologies, however, inflammatory profiles may be able to distinguish between different etiologies of infections. In this review, we summarize the role and the discriminating potency of host-derived inflammatory biomarkers in the context...

... cognitive performance (MoCA, ROC = 0.73 for bottom quartile) and impairments in daily living (Mod S&E, ROC = 0.79 for the bottom quartile). Longitudinal studies are needed to evaluate the potential of LRRK2 as prognostic biomarker for PD. Compared with common genetic markers present in LRRK2 linked...

... correlates with the progression of melanocyte-derived malignancies suggests TRIB2 as a meaningful biomarker to both diagnose and stage melanoma. In addition, interfering with TRIB2 activity might be a therapeutic strategy for the treatment of several different tumour types. This work was supported...

... associated with a plethora of clinical conditions, and these proteins therefore have potential utility as biomarkers of disease and/or response to therapeutic intervention. The present article summarizes current knowledge relating to extracellular cell stress proteins as biomarkers of human disease. 1...

...David M. Favara; Alison H. Banham; Adrian L. Harris Epidermal growth factor, latrophilin and seven-transmembrane domain-containing 1 (ELTD1), an orphan G-protein-coupled receptor (GPCR) belonging to the adhesion GPCR family, has recently been identified as a potential cancer biomarker and a novel...

... of endogenous short non-coding single-stranded RNA oligonucleotides that regulate gene expression post-transcriptionally. Quantification of urinary microRNAs offers an alternative approach to the identification of chronic kidney disease biomarkers. Fassett et al. [ 11 ] have described comprehensively...

...-VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor (VEGF) The mammalian VEGF (vascular endothelial growth factor) family consists of five homodimeric polypeptides of 40 kDa: VEGF-A, -B, -C and -D and PlGF (placental growth factor). VEGF...

...Jayne E. Telford; Margaret A. Doherty; Tharmala Tharmalingam; Pauline M. Rudd Glycosylation modifications have been reported in a number of disease states and, as a result, there is significant focus on the discovery and development of glycan-based biomarkers. Glyco-biomarkers have the potential...

.... An increasing number of new alcohol biomarkers that are the result of alcohol-induced glycoconjugate metabolic errors have appeared in the literature. Glycoconjugate-related alcohol markers are involved in, or are a product of, altered glycoconjugate metabolism, e.g. CDT (carbohydrate-deficient transferrin), SA...

... these glycans as a screening tool for the early diagnosis of the disease, or a target-specific therapeutic agent. biomarker β1,6-branched N-linked oligosaccharide glycosylation melanoma N-acetylglucosaminyltransferase V 11 9 2010 © The Authors Journal compilation © 2011 Biochemical...

... candidate to identify new biomarkers. Backing this claim for a perspective in clinical practice are recent discoveries that even seemingly subtle changes in the glycan structure of glycoproteins, such as a N-glycan core substitution by a single sugar moiety, have far-reaching functional consequences...

... Society 2010 biomarker glycosylation high-throughput glycoanalysis HPLC systems biology Glycosylation of proteins is among the most abundant and important post-translational modifications of proteins, which is evidenced by the functions it plays in diverse biological processes, e.g...

...Qizhi Huang; Laura J. Hardie Biomarkers are needed to screen multiple stages in the clinical pathway of Barrett's oesophagus patients; from disease diagnosis to risk stratification and predicting response to therapy. Routes to the identification of biomarkers have been recognized by known molecular...

...Clare R. Foster; Stefan A. Przyborski; Robert G. Wilson; Christopher J. Hutchison Lamins are multifunctional proteins that are often aberrantly expressed or localized in tumours. Here, we endeavour to assess their uses as cancer biomarkers: to diagnose tumours, analyse cancer characteristics...

... implemented. For over a decade, microarrays have provided novel insight into many complex human diseases. Microarray-based discovery can be classified into three components, biomarker detection, disease (sub)classification and identification of causal mechanism, in order of accomplishment. Within...

... the quantification and identification of novel biomarkers of chronic lung diseases using techniques such as proteomics. 1 To whom correspondence should be addressed (email bln1@soton.ac.uk ). 4 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 Contaminants apart...

... tumours. Consequently, lamin A/C is a prognostic biomarker in CRC. In vitro studies suggest that lamin A is an upstream regulator of a pathway linking actin dynamics to loss of cell adhesion, leading to enhanced cell motility and consequently increased invasive potential within a tumour. The finding...

... correspondence should be addressed (email s.loft@pubhealth.ku.dk ). 30 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 base excision repair biomarker DNA damage DNA repair nucleotide excision repair oxidative damage Multiple exogenous and endogenous...

... and offers potential for development of novel biomarkers of inflammatory diseases. In the present paper, we review some of the progress that has been made towards this goal. 1 To whom correspondence should be addressed (email c.m.spickett@strath.ac.uk ). 30 5 2008 © The Authors Journal...

... to the development of reliable biomarkers. 1 To whom correspondence should be addressed (email mmm2@le.ac.uk ). 6 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 biomarker chemoprevention indole plasma profiling polyphenol tumour subtype In order...

... and bioremediation, natural product synthesis and its manipulation, tools for exploiting CYPs and using CYPs as biomarkers and drug targets. Fundamental studies on diverse structure and function, on the ecological and evolution of CYPs through geological time and in drug/pesticide resistance also contribute...

... of suitable binding molecules that can cope effectively with protein diversity. The second format involves the capture of proteins by biochemical or intermolecular interaction, coupled with direct detection by MS. This technology is available as the ProteinChip® Biomarker System. ProteinChip technology uses...