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Keywords: bioinformatics
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Articles
Biochem Soc Trans (2020) 48 (4): 1337–1352.
Published: 17 July 2020
... discovered in the last five years. A bioinformatics perspective is held here, hence sequence and structure comparison overview is presented, and also a comparison of genomic neighbourhoods of the families. We perform a phylum-level census of the families. Also, we discuss apparent pseudokinases that turned...
Articles
Biochem Soc Trans (2015) 43 (5): 807–811.
Published: 09 October 2015
... in the column i and p ik the fractional frequency of the k th unique element in column i . © 2015 Authors; published by Portland Press Limited 2015 bioinformatics protein structure proteome scoring function tandem repeats Next-generation sequencing platforms are revolutionizing...
Articles
Biochem Soc Trans (2014) 42 (6): 1780–1785.
Published: 17 November 2014
... identified as a serendipitous discovery. Hence, characterization of moonlighting proteins using bioinformatics approaches can have a significant impact on the overall understanding of protein function. In this work, we provide a short review of existing computational approaches for illuminating...
Articles
Biochem Soc Trans (2014) 42 (6): 1692–1697.
Published: 17 November 2014
... if bioinformatics could predict protein multifunctionality, especially because of the large amounts of sequences coming from genome projects. In the present article, we describe several approaches that use sequences, structures, interactomics and current bioinformatics algorithms and programs to try to overcome...
Articles
Biochem Soc Trans (2010) 38 (5): 1290–1293.
Published: 24 September 2010
... in a rich source of novel glycan structures and new possibilities for glycoprospecting and glycoengineering. However, assigning genetic information in predicted glycan biosynthetic pathways to the overall structural information is complex. Bioinformatic analysis is required, linked to systematic mutagenesis...
Articles
Biochem Soc Trans (2008) 36 (1): 94–98.
Published: 22 January 2008
... ). 30 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 ATPase associated with various cellular activities (AAA) bioinformatics protein biochemistry Sulfolobus solfataricus Vps4 homologue AAA (ATPase associated with various cellular activities...
Articles
Biochem Soc Trans (2007) 35 (3): 599–603.
Published: 22 May 2007
... as therapeutic drug targets where it is crucial to be able to delineate not only parology for specificity, but also orthology in species used for disease model testing and safety assessment [ 4 ]. angiotensin-converting enzyme (ACE) bioinformatics genome database phylogenetic analysis protease...
Articles
Biochem Soc Trans (2006) 34 (2): 313–316.
Published: 20 March 2006
... will play an even more vital role in the generation of future therapies. 1 To whom correspondence should be addressed (email Graham.Belfield@astrazeneca.com ). 20 1 2006 © 2006 The Biochemical Society 2006 bioinformatics drug discovery drug target identification molecular...
Articles
Biochem Soc Trans (2004) 32 (4): 601–605.
Published: 01 August 2004
.... Biochemical analysis has identified both general and specific mRNA-binding proteins as components of the regulation of chloroplast translation, and has revealed that chloroplast translation is related to bacterial translation but is more complex. Utilizing proteomic and bioinformatic analyses, we have...
Articles
Biochem Soc Trans (2003) 31 (2): 428.
Published: 01 April 2003
... cycle control, apoptosis, gene regulation and metastasis. As the number of these biological targets increases, reliance on bioinformatics and chemoinformatics to improve decision making, by identifying characteristics of successful drugs and sharing knowledge gained within the scientific community, has...