... mitochondrial function. In vitro experiments utilizing a wide variety of transformed cell types (PC12, HCN1A, SH-SY5Y, N2a cells) have shown that wild-type (WT) APP expression reduced bioenergetic function of cells, including reduced ATP production, COX activity, and altered calcium homeostasis [ 12 , 48 , 50...

... and cognitive impairments (e.g. [ 8 ]). Correspondence: João M. N. Duarte ( joao.duarte@med.lu.se ) 17 10 2022 10 12 2022 12 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 bioenergetics central nervous system...

... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioenergetics ischaemia-reperfusion injury membrane potential mitochondria reactive oxygen species thermodynamics The operation of a biological system is like the operation...

... in the structural attachment of the δ -subunit, which is asymmetrically bound on top of the F 1 headpiece, which once bound, irreversibly determines the position of two b -subunits composing the peripheral stalk ( Figure 1D ). bioenergetics F1Fo-ATP synthase ion-to-ATP ratio photosynthesis regulation...

... 10.1073/pnas.1311660110 39 Kovac , S. , Domijan , A.M. , Walker , M.C. and Abramov , A.Y. ( 2012 ) Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death . J. Cell Sci. 125 (Pt 7 ), 1796 – 1806 10.1242/jcs.099176 40 Kovac , S...

... the enlarged creatine pool, resulting in 2-fold higher ADP and reduced |Δ G ATP |, closely mimicking the impaired bioenergetics observed in heart failure models [ 44 – 46 ]. Further studies, utilising metabolomics and proteomics approaches, showed that excessive creatine has wide-ranging effects on cellular...

... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioenergetics cardiac hypertrophy metabolism mitochondrial dysfunction sodium Isolated mitochondria experiments should be treated with caution, given...

...Charles Affourtit; Ben Alberts; Jonathan Barlow; Jane E. Carré; Anthony G. Wynne The canonical model of glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells predicts a glucose-induced rise in the cytosolic ATP/ADP ratio. Such bioenergetic sensitivity to metabolic fuel is unusual...

... © 2013 The Authors 2013 bioenergetics complex I membrane protein structure NADH:ubiquinone oxidoreductase respiratory chain X-ray crystallography Complex I (NADH:ubiquinone oxidoreductase, EC 1.6.5.3) plays a central role in the respiratory chain in mitochondria and many bacteria...

... in this subclass of enzymes. 1 To whom correspondence should be addressed (email matthias.stein@mpi-magdeburg.mpg.de ). 8 8 2013 © 2013 The Authors 2013 bioenergetics hydrogen conversion iron–sulfur cluster (Fe–S cluster) oxygen-tolerant hydrogenase protein structural modelling...

.... Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T Gene 2008 411 69 76 40 Amo T. Brand M.D. Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis...

... a bioenergetic crisis by so severely limiting cellular access to extracellular nutrients that autophagy is insufficient to meet the metabolic demands of the cell. In keeping with this bioenergetic explanation for ceramide toxicity, methyl pyruvate, a membrane-permeable nutrient, protects cells from ceramide...

... for cytosolic ATP, but as the ion-pumping ATPases and oxidative phosphorylation are less sensitive towards the cytosolic ATP, other ATP-consumers have low control over these pathways. 6 7 1999 © 2000 Biochemical Society 2000 bioenergetics isolated perfused liver top-down metabolic control...