... analysis suggests the existence of a binding site for OT peptides within the common transmembrane core region of the receptor, but it appears extremely difficult to identify receptor or ligand residues that could explain the selectivity of OT to its receptors. We remain confident that the presented...

... to a lysine in TM7, deep within the helical bundle, and small ligands, such as amine neurotransmitters and non-peptide analogues of peptide hormones, also bind within the corresponding region of their cognate receptors. In addition, activation of GPCRs involves relative movement of TM helices to present G...

... proteins, but generally do not bind their native counterparts. However, they also recognize certain folded proteins with high specificity. Therefore an important question is, how does Hsp70 combine in its substrate specificity both seemingly contradictory properties? The most extensive analysis...

...D. van der Helm; R. Chakraborty; A. D. Ferguson; B. S. Smith; L. Esser; J. Deisenhofer The recent structure determination of FecA, with and without ligand, shows the existence of two gates. These are the extracellular loops closing over the binding site and the plug located inside the barrel...