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Keywords: bile acid
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Biochem Soc Trans (2014) 42 (2): 244–249.
Published: 20 March 2014
...Thijs W.H. Pols TGR5 (Takeda G-protein-coupled receptor 5) [also known as GPBAR1 (G-protein-coupled bile acid receptor 1), M-BAR (membrane-type receptor for bile acids) or GPR131 (G-protein-coupled receptor 131)] is a G-protein-coupled receptor that was discovered as a bile acid receptor. TGR5 has...
Biochem Soc Trans (2010) 38 (2): 313–319.
Published: 22 March 2010
... metaplasia and can be activated in oesophageal cell cultures by treatment with bile acids. We have investigated the ability of Cdx2 to bring about intestinal transformations in oesophageal epithelium. Our results show that Cdx2 can activate a programme of intestinal gene expression when overexpressed in HET...
Biochem Soc Trans (2010) 38 (2): 348–352.
Published: 22 March 2010
.... Dannenberg A.J. Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids Gastroenterology 2001 121 1391 1399 16 Livstone E.M. Sheahan D.G. Behar J. Studies of esophageal epithelial cell proliferation in patients...
Biochem Soc Trans (2004) 32 (1): 92–96.
Published: 01 February 2004
... the activity of LXR by antagonizing the effect of activators of this receptor, thus contributing to cholesterol accumulation in macrophages. Bile acid synthesis, which represents the final step of reverse cholesterol transport, is transcriptionally regulated by several nuclear receptors at the level...
Biochem Soc Trans (2003) 31 (2): 397–406.
Published: 01 April 2003
... efficient DNA condensation and subsequently drug delivery (i.e. with DNA as the drug) can be brought about using novel polyamine conjugates. Taking further advantage of the functionalization of specific steroids (e.g. cholesterol and certain bile acids), we have designed and prepared novel fluorescent...