... as bicelles and nanodiscs: the first step is based on detergent solubilization, necessitating optimization of the nature and the concentration of the detergent(s) used, creating potential difficulties in reconstitution and of course loss of protein activity. 1 To whom correspondence should...

... to purification and further biochemical study. 1 To whom correspondence should be addressed (email t.r.dafforn@bham.ac.uk ). 11 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 amphipol bicelle membrane protein nanoparticle solubilization surfactant...